Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Autor:
Jorge Cruz-Reyes, Andrew Hillhouse, Daniel Camilo Osorio Hurtado, Alasdair Ivens, Xiuren Zhang, Pawan K. Doharey, Joshua Meehan, Zachary T Goodall, Achim Schnaufer, Vikas Kumar, James J. Cai
Publikováno v:
Kumar, V, Ivens, A, Goodall, Z, Meehan, J, Doharey, P K, Hillhouse, A, Hurtado, D O, Cai, J J, Zhang, X, Schnaufer, A & Cruz-Reyes, J 2020, ' Site-specific and mRNA-specific control of accurate mRNA editing by a helicase complex in trypanosomes ', RNA, vol. 26, no. 10, rna.076513.120 . https://doi.org/10.1261/rna.076513.120
RNA
RNA
Trypanosome U-insertion/deletion RNA editing in mitochondrial mRNAs involves guide RNAs (gRNAs) and the auxiliary RNA editing substrate binding complex (RESC) and RNA editing helicase 2 complex (REH2C). RESC and REH2C stably copurify with editing mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544f1407045fc8df53ea00d87dc63e7
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
Autor:
Suzanne M. McDermott, Z. Hong Zhou, H. Ulrich Göringer, Alena Zíková, Kenneth Stuart, Igor Cestari, Reza Salavati, Stephen L. Hajduk, Julius Lukeš, Ruslan Aphasizhev, Dmitri A. Maslov, Jason Carnes, Achim Schnaufer, Inna Aphasizheva, Larry Simpson, Torsten Ochsenreiter, Jorge Cruz-Reyes, Laurie K. Read, André Schneider, Susan Madison-Antenucci, Vyacheslav Yurchenko, Liye Zhang, Juan D. Alfonzo, Sara L. Zimmer
Publikováno v:
Aphasizheva, I, Alfonzo, J, Carnes, J, Cestari, I, Cruz-Reyes, J, Göringer, H U, Hajduk, S, Lukeš, J, Madison-Antenucci, S, Maslov, D A, McDermott, S M, Ochsenreiter, T, Read, L K, Salavati, R, Schnaufer, A, Schneider, A, Simpson, L, Stuart, K, Yurchenko, V, Zhou, Z H, Zíková, A, Zhang, L, Zimmer, S & Aphasizhev, R 2020, ' Lexis and grammar of mitochondrial RNA processing in Trypanosomes ', Trends in Parasitology, vol. 36, no. 4, pp. 337-355 . https://doi.org/10.1016/j.pt.2020.01.006
Trends in parasitology, vol 36, iss 4
Trends in parasitology, vol 36, iss 4
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171b9f7520b2af84d845636eb4343d1
https://hdl.handle.net/20.500.11820/def562e4-fc49-427d-84a3-da811b3f009b
https://hdl.handle.net/20.500.11820/def562e4-fc49-427d-84a3-da811b3f009b
Autor:
Jorge Cruz-Reyes, Joshua Meehan, Karissa Hughes, Pawan K. Doharey, Shelly Gulati, Vikas Kumar, Mary Grace Martinez, Blaine H. M. Mooers
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
Uridylate insertion/deletion RNA editing inTrypanosoma bruceiis a complex system that is not found in humans, so there is interest in targeting this system for drug development. This system uses hundreds of small non-coding guide RNAs (gRNAs) to modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86526f60b24f7c8ab3a3e12703e89126
https://doi.org/10.1101/524702
https://doi.org/10.1101/524702
Autor:
Jason Carnes, Suzanne M. McDermott, Kenneth Stuart, Ira J. Blader, Juan Alfonzo, Jorge Cruz-Reyes
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
mSphere, Vol 3, Iss 1, p e00585-17 (2018)
mSphere, Vol 3, Iss 1, p e00585-17 (2018)
Editosomes are the multiprotein complexes that catalyze the insertion and deletion of uridines to create translatable mRNAs in the mitochondria of kinetoplastids. Recognition and cleavage of a broad diversity of RNA substrates in vivo require three f
Autor:
Alevtina G. Zhelonkina, Julie A. Law, Jorge Cruz-Reyes, Barbara Sollner-Webb, Catherine E. Huang, Vadim S. Alatortsev, Sean F. O'Hearn
Publikováno v:
RNA. 12:476-487
Trypanosome RNA editing is massive post-transcriptional U-insertion and U-deletion, which generates mature mRNA coding regions through cycles of endonuclease, terminal U transferase (TUTase) or 3′-U-exo, and ligase action. Both types of editing are
Publikováno v:
Molecular and Cellular Biology. 22:4652-4660
Trypanosome RNA editing is a unique U insertion and U deletion process that involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation. This editing can occur at massive levels and is directed by base pairing of trans-acti
Autor:
Blaine H. M. Mooers, Chiedza Kanyumbu, Shelly Gulati, Vikas Kumar, Danielle Lane, Jorge Cruz-Reyes
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a381-a381
Publikováno v:
The EMBO Journal. 16:4069-4081
Kinetoplastid mitochondrial RNA editing, the insertion and deletion of U residues, is catalyzed by sequential cleavage, U addition or removal, and ligation reactions and is directed by complementary guide RNAs. We have purified a approximately 20S en