Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jonathan Pinkney"'
Autor:
Jonathan Pinkney, Ornella Cominetti, Alison N. Jeffery, Sebastiano Collino, Jörg Hager, Laeticia Da Silva, Martin Kussmann, Joanne Hosking, François-Pierre Martin
Publikováno v:
Pediatric Diabetes. 20:832-841
BACKGROUND While insulin resistance (IR) is associated with specific metabolite signatures in adults, there have been few truly longitudinal studies in healthy children, either to confirm which abnormalities are present, or to determine whether they
Autor:
Jonathan Pinkney
Publikováno v:
Current Opinion in Clinical Nutrition and Metabolic Care. 17:497-502
Purpose of review To discuss recent research on the role of ghrelin in the regulation of carbohydrate and lipid metabolism in the context of its wider role in regulating energy balance. Recent findings Ghrelin possesses a range of centrally and perip
Autor:
Theodora Tzanavari, Chen Bing, Jonathan Pinkney, Q. Ding, Tomas Mracek, Katarina Kos, Paul Trayhurn, John P.H. Wilding
Publikováno v:
Clinical Endocrinology. 72:334-341
INTRODUCTION Zinc-alpha2-glycoprotein (ZAG) is a novel adipokine, which may act locally to influence adipocyte metabolism. This study assessed the effect of increased adiposity on ZAG expression in adipose tissue in human subjects. The study also exa
Publikováno v:
Journal of diabetes and its complications. 29(7)
To investigate the association between circulating non-transferrin-bound iron [NTBI], and markers of oxidative stress, endothelial function and inflammation in subjects with type 2 diabetes and non-diabetic subjects with varying degrees of obesity.Pl
Publikováno v:
Cytokine. 21:32-37
The secretion of interleukin-6 (IL-6) is modulated by immune, hormonal and metabolic stimuli in a cell-specific manner. We investigated the effect of cytokines, TNFalpha and IL-1beta, and insulin on IL-6 release from human adipocytes and peripheral b
Autor:
Stephen E. Humphries, Jonathan Pinkney, Vidya Mohamed-Ali, David A. York, Rosaire Gray, Louise Flower, Jaswinder K. Sethi, Gökhan S. Hotamisligil
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:5864-5869
Circulating IL-6 levels are elevated in obesity. Although IL-6 is expressed in adipose tissue, neither its regulation nor cell of origin is well characterized. Here we investigated the beta-adrenergic regulation of IL-6 release in a combination of st
Autor:
Colin H. Bolton, Leonie G. Downs, Jason G.G. Victory, Charles R.V. Tomson, Jeremy F. Dwight, Michael I. Mackness, Jonathan Pinkney
Publikováno v:
Nephrology Dialysis Transplantation. 16:1189-1197
Background. Chronic renal failure (CRF) is associated with an increased risk of ischaemic heart disease (IHD), but the mechanisms responsible are controversial. We investigated the relationship of two sets of candidate mechanisms-indices of LDL oxida
Publikováno v:
International Journal of Obesity. 22:1145-1158
The discovery of leptin has imparted great impetus to adipose tissue research by demonstrating a more active role for the adipocyte in energy regulation. Besides leptin, however, the adipose tissue also secretes a large number other signals. Cytokine
Autor:
Arshia Panahloo, Jonathan Pinkney, John S Yudkin, Simon W. Coppack, S Goodrick, Vidya Mohamed-Ali
Publikováno v:
Diabetic Medicine. 14:376-380
In non-diabetic subjects, insulin concentrations and insulin resistance are clearly connected, and both correlate with leptin levels, making interpretations about mechanisms difficult. In non-insulin-dependent (Type 2) diabetes mellitus (NIDDM), howe
Publikováno v:
The American journal of clinical nutrition. 97(3)
Background: There is evidence that reducing blood glucose concentrations, inducing weight loss, and improving the lipid profile reduces cardiovascular risk in people with type 2 diabetes. Objective: We assessed the effect of various diets on glycemic