Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joanna A. Phipps"'
Autor:
Elena Ivanova, Connie H Wong, Bang V. Bui, Gene Venables, Samuel A Mills, Michael A Dixon, Flora Hui, Zheng He, Kirstan A. Vessey, Vickie Hy Wong, Josh Tonc, James C Young, Botir T. Sagdullaev, Andrew I Jobling, Ursula Greferath, Erica L. Fletcher, Joanna A. Phipps
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This work identifies a role for microglia, the innate immune cells of the CNS, in the local control of the retinal vasculature and identifies deficits early in diabetes. Microglia contact neurons and vasculature and express several vasoa
Autor:
Joanna A. Phipps, Erica L. Fletcher, James S. Wiley, Ben J. Gu, Mai X. Tran, Andrew I Jobling, Michael A Dixon, Ursula Greferath, Robyn H. Guymer, Paul N. Baird, Kirstan A. Vessey
Publikováno v:
The American Journal of Pathology. 187:1670-1685
Age-related macular degeneration (AMD) is a leading cause of irreversible, severe vision loss in Western countries. Recently, we identified a novel pathway involving P2X7 receptor scavenger function expressed on ocular immune cells as a risk factor f
Autor:
Robb U. de Iongh, Felix P. Aplin, Joanna A. Phipps, Ursula Greferath, Tracy Ho, Andrew I Jobling, Kirstan A. Vessey, Erica L. Fletcher
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 32:509-517
Purines, when present in the extracellular space, can mediate fast neurotransmission in the retina and central nervous system. Over the last decade there has been emerging evidence for the expression of P2X and P2Y receptors in a range of retinal neu
Autor:
Ursula Greferath, Kirstan A. Vessey, Erica L. Fletcher, Joanna A. Phipps, Anna Y. Wang, Michael A Dixon, Andrew I Jobling
Publikováno v:
Experimental eye research. 187
The retina is known to have a local renin-angiotensin system (RAS) and dysfunction in the RAS is often associated with diseases of the retinal vasculature that cause irreversible vision loss. Regulation of the retinal vasculature to meet the metaboli
Autor:
Alexandra Grubman, Anthony R. White, Kirstan A. Vessey, Joanna A. Phipps, Andrew I Jobling, Philipp von Eisenhart-Rothe, Ursula Greferath, Linda J Fothergill, Erica L. Fletcher
Publikováno v:
Investigative ophthalmologyvisual science. 59(12)
Purpose Vision loss caused by photoreceptor death represents one of the first symptoms in neuronal ceroid lipofuscinosis, a condition characterized by accumulation of intracellular waste. Cln6nclf mice have a naturally occurring mutation in ceroid-li
Autor:
Robb U. de Iongh, Tracy Ho, Ursula Greferath, Erica L. Fletcher, Andrew I Jobling, Kirstan A. Vessey, Samuel A Mills, Joanna A. Phipps, Michelle Waugh
Publikováno v:
Optometry and Vision Science
Over the recent years, there have been tremendous advances in our understanding of the genetic and environmental factors associated with the development of age-related macular degeneration (AMD). Examination of retinal changes in various animals has
Autor:
Andrew I Jobling, Kirstan A. Vessey, Joanna A. Phipps, Felix P. Aplin, Robbert U de Iongh, Tracy Ho, Ursula Greferath, Erica L. Fletcher
Publikováno v:
The Journal of Comparative Neurology
Many common causes of blindness involve the death of retinal photoreceptors, followed by progressive inner retinal cell remodeling. For an inducible model of retinal degeneration to be useful, it must recapitulate these changes. Intravitreal administ
Autor:
Joanna A. Phipps, Erica L. Fletcher, Mai X. Tran, Andrew I Jobling, Nupur Nag, Alice Brandli, Kirstan A. Vessey
Publikováno v:
Investigative Opthalmology & Visual Science. 59:487
Purpose: This study explored whether the proangiogenic factor Angiotensin II (AngII) had a direct effect on the activation state of microglia via the Angiotensin type 1 receptor (AT1-R). Methods: Microglial dynamic activity was investigated in live r
Autor:
Edward P. Feener, Joanna A. Phipps
Publikováno v:
Kidney International. 73(10):1114-1119
Diabetic retinopathy and diabetic nephropathy are common microvascular complications of diabetes. The kallikrein-kinin system (KKS) has been implicated in the development of both conditions, and, in particular, bradykinin and its receptors have been
Autor:
Erica L. Fletcher, Lidia Trogrlic, Andrew I Jobling, Kirstan A. Vessey, Ursula Greferath, Joanna A. Phipps, Michelle Waugh, Tracy Ho
Publikováno v:
Investigative ophthalmologyvisual science. 56(2)
PURPOSE: The chemokine Ccl2, or monocyte chemoattractant protein-1 (MCP-1), has previously been identified as playing a potential role in many ocular diseases; however, its role in mice is less clear. We sought to correlate changes in retinal pigment