Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Hiroshi Imamura"'
Autor:
Hiroshi Imamura, Shinya Honda
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12042 (2023)
Antibody aggregation, followed by acid denaturation and neutralization of pH, is one of the reasons why the production of therapeutic monoclonal antibodies (mAbs) is expensive. Determining the structural details of acid-denatured antibodies is import
Externí odkaz:
https://doaj.org/article/6499adb9050c4859bcf550d6cea62bb0
Autor:
Yukinori Kurokawa, Junya Fujita, Tomono Kawase, Yutaka Kimura, Hiroshi Imamura, Hisato Kawakami, Masahiro Goto, Kazuhiro Nishikawa, Norimasa Fukushima, Shugo Ueda, Naotoshi Sugimoto, Jin Matsuyama, Taroh Satoh, Daisuke Sakai, Takao Tamura, Toshio Shimokawa
Publikováno v:
International Journal of Clinical Oncology. 26:1871-1880
To compare irinotecan-alone, paclitaxel-alone, and each combination chemotherapy with S-1 in patients with advanced gastric cancer (AGC) that is refractory to S-1 or S-1 plus cisplatin (SP). Patients with AGC after first-line chemotherapy with S-1 or
Autor:
Tomonari Sumi, Hiroshi Imamura
Publikováno v:
Protein Science : A Publication of the Protein Society
Proteins are folded to avoid exposure of the non-polar groups to water because water-mediated interactions between nonpolar groups are a promising factor in the thermodynamic stabilities of proteins-which is a well-accepted view as one of the unique
Publikováno v:
The Journal of Physical Chemistry B. 125:8855-8861
The pressure dependence of the solubility of hydrophobic solutes in aqueous solutions is equivalent to volume changes upon hydrophobic hydration. This phenomenon has been attributed to the packing effects induced by the van der Waals volume differenc
Autor:
Tomonari Sumi, Sayaka Mukaide, Hiroshi Imamura, Kunikazu Moribe, Kenjirou Higashi, Ziqiao Chen, Takeshi Morita
Publikováno v:
Nano Letters. 21:1303-1310
Polymeric micelles are invaluable media as drug nanocarriers. Although knowledge of an interaction between the micelles is a key to understanding the mechanisms and developing the superior functions, the interaction potential surface between drug-inc
Autor:
Tomonari Sumi, Tetsuo Sakka, Kota Hashimoto, Naoya Nishi, Ryosuke Sawazumi, Hiroshi Imamura, Haru Kitaoka, Ken-ichi Amano, Kazuhiro Fukami
Publikováno v:
Chemistry Letters. 49:1017-1021
Small-angle X-ray and neutron scatterings can measure the structure factor of dispersed particles (macromolecules or colloidal particles), which can estimate the pair distribution function and the ...
Autor:
Tomonari Sumi, Setsu Nakae, Tsuyoshi Shirai, Yasuhiro Isogai, Ken ichi Takahashi, Hiroshi Imamura
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102920-(2021)
iScience
iScience
Summary Myoglobin (Mb) is highly concentrated in the myocytes of diving mammals such as whales and seals, in comparison with land animals, and its molecular evolution has played a crucial role in their deep-sea adaptation. We previously resurrected a
Publikováno v:
Analytical Chemistry. 91:4640-4648
Aggregates of therapeutic proteins that can contaminate drug products during manufacture is a growing concern for the pharmaceutical industry because the aggregates are potentially immunogenic. Electron microscopy is a typical, indispensable method f
Autor:
Shinya Honda, Hiroshi Imamura
Publikováno v:
Seibutsu Butsuri. 59:147-150
Autor:
Ryohei Kuwatsuru, Hirofumi Ichida, Yoichi Ishizaki, Seiji Kawasaki, Yu Gyoda, Jiro Yoshimoto, Hiroshi Imamura
Publikováno v:
Journal of Gastroenterology and Hepatology. 34:1242-1248
Background and aim The natural course and clinical implications of hypovascular lesions on dynamic computed tomography and/or gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging were investigated. Methods W