Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Harley I. Kornblum"'
Autor:
Hui Mao, Lingjing Jin, Yuhong Du, Eun Hee Ahn, Xia Liu, Seong Su Kang, Keqiang Ye, Kecheng Lei, Hua Li, Alvaro G. Alvarado, Shilin Luo, Harley I. Kornblum, Xiaoxia Gu, Haian Fu, Bing Ji
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-21 (2020)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi 1 (GSTP1) are commonly upregulated in
Autor:
Januka Khanal, Daniel P. Cahill, Joseph Buehler, Diana D. Shi, Yu-Fen Lin, Misty S. Martin-Sandoval, Michael M Levitt, Keith L. Ligon, Harley I. Kornblum, Adam C. Wang, Sungwoo Lee, Dennis M. Bonal, John M. Asara, Mark A. Lehrman, Isaac S. Harris, Andreas Janzer, Cylaina E. Bird, Michael Jeffers, Ralph J. DeBerardinis, William G. Kaelin, Tammie Dang, Nathalie Y. R. Agar, Sylwia A. Stopka, Lauren C. Gattie, Stefan Gradl, Lauren G. Zacharias, Michael S. Regan, Quang-Dé Nguyen, Tak W. Mak, Sabina Signoretti, Kalil G. Abdullah, Peter Ly, Andreas Sutter, Timothy E. Richardson, Samuel K. McBrayer, Thomas P. Mathews, Milan R. Savani, Jennifer E. Endress, Min Xu, Wenhua Gao, Bofu Huang, Rebecca B. Jennings, Ryan E. Looper
SUMMARYMutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they appear less active in aggressive glioma, underscoring the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef99b65b0828b3d636a1f8cfa0b31ac5
https://doi.org/10.1101/2021.11.30.470443
https://doi.org/10.1101/2021.11.30.470443
Autor:
Harley I. Kornblum, Riki Kawaguchi, Vivek Swarup, Steven A. Goldman, Alvaro G. Alvarado, Kaleab Tessema, Sree Deepthi Muthukrishnan
Publikováno v:
Neuro Oncol
The great phenotypic heterogeneity of glioblastoma (GBM) – both inter and intratumorally – has hindered therapeutic efforts. While genome-based molecular subtyping has revealed that GBMs may be parsed into several molecularly distinct categories,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2940807a17b6d3bd6b308ccced6c71c
https://europepmc.org/articles/PMC8598706/
https://europepmc.org/articles/PMC8598706/
Autor:
Paul S. Mischel, Sihan Wu, Wei Zhang, Jeremy N. Rich, Andrey Rzhetsky, Jun Tang, Frank B. Furnari, Harley I. Kornblum, Aaron M. Armando, Ryan C. Gimple, Ellis J. Curtis, Atif Ali Khan, Derek A. Wainwright, Shunichiro Miki, Briana C. Prager, Timothy F. Cloughesy, Junfeng Bi, Huijun Yang, Oswald Quehenberger, Benjamin F. Cravatt, Tomoyuki Koga
The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify SMPD1, an enzyme that regulates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fda624483f82009e300e8d49f6b882f
https://doi.org/10.1101/2021.03.16.435487
https://doi.org/10.1101/2021.03.16.435487
Autor:
Alex Reed, Ryan C. Gimple, Derek A. Wainwright, Timothy F. Cloughesy, Atif Ali Khan, Jeremy N. Rich, Harley I. Kornblum, Tomoyuki Koga, Huijun Yang, Jun Tang, Frank B. Furnari, Junfeng Bi, Benjamin F. Cravatt, Yuchao Gu, Paul S. Mischel, Oswald Quehenberger, Ivy Tsz-Lo Wong, Hui Jing, Shunichiro Miki, Briana C. Prager, Aaron M. Armando, Andrey Rzhetsky, Ellis J. Curtis, Sihan Wu, Wei Zhang
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109957-(2021)
Summary The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodiest
Autor:
Sameer A. Greenall, Harley I. Kornblum, Shengnan C Chen, Olan Dolezal, Lesley A. Pearce, Ekatarina Seminova, Mathew McKenzie, Timothy E. Adams, Terrance Grant Johns, Mani Kuchibhotla, Raelene Endersby, Kerrie L. McDonald, John D. Bentley
Publikováno v:
Neuro Oncol
Background Although epidermal growth factor receptor (EGFR) and its truncated, autoactive mutant EGFR variant (v)III are bona fide drivers of tumorigenesis in some gliomas, therapeutic antibodies developed to neutralize this axis have not improved pa
Publikováno v:
Methods in Molecular Biology ISBN: 9781071610596
We will first describe analysis of MDSC subsets from patient tumors with multicolor flow cytometry. The key components of this methodology are to obtain viable single cell suspensions and eliminate red blood cell contamination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbce9a7c0a3c5ae53a82c32fab19040b
https://doi.org/10.1007/978-1-0716-1060-2_13
https://doi.org/10.1007/978-1-0716-1060-2_13
Autor:
Michael C. Condro, Weikun Xiao, Harley I. Kornblum, Alireza Sohrabi, Elnaz Guivatchian, Arshia Ehsanipour, Jesse Liang, Stephanie K. Seidlits
Publikováno v:
Neuro Oncol
INTRODUCTION Glioblastoma (GBM) is a highly infiltrative and lethal brain cancer. Previous studies have suggested that GBM tumors are stiffer than healthy brain tissues. We posit that local changes in the mechanical microenvironment near the tumor/ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e8fe1ef21e9932bc949f79bf992a86
https://europepmc.org/articles/PMC7651700/
https://europepmc.org/articles/PMC7651700/
Autor:
Soniya Bastola, Victoria L. Flanary, Riki Kawaguchi, Daisuke Yamashita, Hackney, Shinobu Yamaguchi, Ichiro Nakano, Satoshi Suehiro, Dolores Hambardzumyan, Marat S. Pavlyukov, Sonomura K, Myriam Gorospe, Takaaki Sato, Harley I. Kornblum, Saya Ozaki, Nakano Ma, David K. Crossman, Toru Kondo, Rachel Munk, Takeharu Kunieda
SummaryThe rise in aging population worldwide is increasing death from cancer, including glioblastoma. Here, we explore the impact of brain aging on glioma tumorigenesis. We find that glioblastoma in older patients and older mice displayed reduced ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886b97ed0048d05dd0d297d509b3de05
https://doi.org/10.1101/2020.10.10.334748
https://doi.org/10.1101/2020.10.10.334748
Autor:
Albert Lai, Kristen K.O. Kim, Daniel Braas, Nathan Vanderveer-Harris, Whitney B. Pope, Pedro R. Lowenstein, Michael C. Condro, Heather R. Christofk, Lea Guo, Maria G. Castro, Ajit S. Divakaruni, Janel E. Le Belle, Jantzen Sperry, Harley I. Kornblum
Publikováno v:
iScience, vol 23, iss 9
iScience, Vol 23, Iss 9, Pp 101453-(2020)
iScience
iScience, Vol 23, Iss 9, Pp 101453-(2020)
iScience
Summary Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c487c0a63272bb2548aae6b9cc19443
https://escholarship.org/uc/item/18p914db
https://escholarship.org/uc/item/18p914db