Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Dayana E. Salas-Leiva, Bruce A. Curtis, Zhenzhen Yi, Martin Kolisko, Shelby K Williams, Jon Jerlström-Hultqvist, Joan Salas-Leiva, Lucie Gallot-Lavallée, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger, Eelco C. Tromer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, 12(1):6003. Nature Publishing Group
Nature Communications, 12(1). Nature Publishing Group
Nature Communications
Nature Communications, 12(1):6003. Nature Publishing Group
Nature Communications, 12(1). Nature Publishing Group
Funder: Canadian Institutes of Health Research (Grant: FRN-142349) Natural Sciences and Engineering Research Council of Canada (Grant: RGPIN 05871-2014)
Cells replicate and segregate their DNA with precision. Previous studies showed that these r
Cells replicate and segregate their DNA with precision. Previous studies showed that these r
Autor:
Martin Kolisko, John M. Archibald, Joan Salas-Leiva, Zhenzhen Yi, Alastair G. B. Simpson, Lucie Gallot-Lavallée, Dayana E. Salas-Leiva, Andrew J. Roger, Bruce A. Curtis, Jon Jerlström-Hultqvist, Geert J. P. L. Kops, Eelco C. Tromer
Cells must replicate and segregate their DNA with precision. In eukaryotes, these processes are part of a regulated cell-cycle that begins at S-phase with the replication of DNA and ends after M-phase. Previous studies showed that these processes wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5af32a6d5e83a3cf600932f7f08bb5c
https://doi.org/10.1101/2021.03.14.435266
https://doi.org/10.1101/2021.03.14.435266
The MPS1 kinase NTE region has helical propensity and preferred conformations towards the TPR domain
Autor:
Yoshitaka Hiruma, Anastassis Perrakis, Geert J. P. L. Kops, Minos-Timotheos Matsoukas, Wouter G. Touw, Georgios A. Spyroulias, Marcellus Ubbink
The mitotic spindle assembly checkpoint (SAC) ensures accurate segregation of chromosomes by preventing onset of anaphase until all chromosomes are properly attached to spindle microtubules. The Monopolar spindle 1 (MPS1) kinase is one of the SAC com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d51494cfdb7c3252b105bc0ec41acd1
https://doi.org/10.1101/2020.03.31.018036
https://doi.org/10.1101/2020.03.31.018036
Autor:
Joseph T Worrall, Pierre Gestraud, Sippe G. de Vries, Sarah E. McClelland, Catalina Salinas‐Luypaert, Karen H. Miga, Susanne M.A. Lens, Vincent Boudreau, Paul S. Maddox, Geert J. P. L. Kops, Daniele Fachinetti, Marie Dumont, Riccardo Gamba, Sjoerd Klaasen
Publikováno v:
EMBO Journal. Nature Publishing Group
EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (2), ⟨10.15252/embj.2019102924⟩
EMBO J
EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (2), ⟨10.15252/embj.2019102924⟩
EMBO J
Intrinsic genomic features of individual chromosomes can contribute to chromosome-specific aneuploidy. Centromeres are key elements for the maintenance of chromosome segregation fidelity via a specialized chromatin marked by CENP-A wrapped by repetit
Autor:
Pim J. Huigs in ‘t Veld, Andrea Musacchio, Geert J. P. L. Kops, Magda Camacho Reis, Lindsey A. Allan, Liu Y, Adrian T. Saurin
The Cyclin B:CDK1 kinase complex is the master regulator of mitosis that phosphorylates hundreds of proteins to coordinate mitotic progression. We show here that, in addition to these kinase functions, Cyclin B also scaffolds a localised signalling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a6eccfe52cdb2585ea5e4e5f8f05ee
https://doi.org/10.1101/726224
https://doi.org/10.1101/726224
Autor:
Spyridon T. Pachis, Anastassis Perrakis, Geert J. P. L. Kops, Yoshitaka Hiruma, Eelco C. Tromer
Publikováno v:
Cell Reports, 26(8), 2101-2112.e6. Cell Press
Cell Reports, Vol 26, Iss 8, Pp 2101-2112.e6 (2019)
Cell Reports, Vol 26, Iss 8, Pp 2101-2112.e6 (2019)
Summary: Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until chromosomes are attached to the mitotic spindle via their kinetochores. MPS1 kinase is recruited to kinetochores to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c068ce0045593947d358648f01856743
https://pure.knaw.nl/portal/en/publications/223682cb-9247-4eea-89c2-241eb89c6cd8
https://pure.knaw.nl/portal/en/publications/223682cb-9247-4eea-89c2-241eb89c6cd8
Autor:
Ábel Vértesy, Banafsheh Etemad, Carlos Sacristan, Timo E. F. Kuijt, Geert J. P. L. Kops, Alexander van Oudenaarden
Publikováno v:
Journal of Cell Science, 132(12). Company of Biologists Ltd
The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by monitoring kinetochore–microtubule interactions. SAC proteins are shed from kinetochores once stable attachments are achieved. Human kinetochores consist of hundreds of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0cd4f6f5b2302878811c5f35b577ed
https://doi.org/10.1101/472407
https://doi.org/10.1101/472407
Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until all chromosomes are attached to the mitotic spindle via their kinetochores. MPS1 kinase is recruited to unattached kinetochor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f3a15aa385c056a20a8aaa6085f9d3
Publikováno v:
Nature Cell Biology. 16:1257-1264
Kinetochores are specialized multi-protein complexes that play a crucial role in maintaining genome stability. They bridge attachments between chromosomes and microtubules during mitosis and they activate the spindle assembly checkpoint (SAC) to arre
Autor:
Nannette Jelluma, Geert J. P. L. Kops
Publikováno v:
Cancer discovery. 4(11)
Summary: Chromosome segregation errors and DNA damage are in a vicious cycle in cancer cells. Bakhoum and colleagues show that the molecular response to damaged DNA during mitosis impairs the chromosome segregation machinery, adding a new level to th