Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Franziska M. Uhl"'
Autor:
Lukas Braun, Erika L. Pearce, Bodo Grimbacher, Annette Schmitt-Graeff, Franziska M. Uhl, Dietmar Pfeifer, Barbara Sauer, Melanie Boerries, Joerg M. Buescher, Enrique de Vega Gomez, Justus Duyster, Geoffroy Andrieux, Stefan F. Martin, Robert Zeiser, Alla Bulashevska, Petya Apostolova, Michele Proietti, Philipp R. Esser, Eileen Haring, Marie Follo
Publikováno v:
Haematologica
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Autor:
Michael D. Buck, Daniel J. Puleston, Mario Fabri, Agnieszka M. Kabat, Katarzyna M. Grzes, Annamaria Regina, Michal A. Stanczak, Francesc Baixauli, Annette E. Patterson, Erika L. Pearce, Ryan Kyle, Joy Edwards-Hicks, Robert Zeiser, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, David O’Sullivan, Jonathan D. Curtis, Cameron S. Field, Edward J. Pearce, Franziska M. Uhl, Matteo Villa, Mauro Corrado, Nisha Rana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8+ T cells, exposure to febril
Autor:
Jonathan D. Curtis, Petya Apostolova, Edward J. Pearce, Joerg M. Buescher, Erika L. Pearce, Annette E. Patterson, Fabian Hässler, David E. Sanin, Franziska M. Uhl, Michal A. Stanczak, David O’Sullivan, Robert Zeiser, Joy Edwards-Hicks, Nina A M Ligthart, Daniel J. Puleston, Katarzyna M. Grzes, Ramon I. Klein Geltink, Mario Fabri, Agnieszka M. Kabat
Publikováno v:
Nature Metabolism
CD8+ effector T (TE) cell proliferation and cytokine production depends on enhanced glucose metabolism. However, circulating T cells continuously adapt to glucose fluctuations caused by diet and inter-organ metabolite exchange. Here we show that tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527fdf8f9482ead8f3a9e4d7a8815d74
https://hdl.handle.net/21.11116/0000-0006-CF32-921.11116/0000-0006-CF34-7
https://hdl.handle.net/21.11116/0000-0006-CF32-921.11116/0000-0006-CF34-7
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Sebastian Halbach, Marina Kreutz, Joy Edwards-Hicks, Melanie Boerries, Justus Duyster, Jörg Büscher, Tobias Madl, Olaf Groß, Sandra Duquesne, David O’Sullivan, Eileen Haring, Wolfgang Melchinger, Gesa Richter, Petya Apostolova, Tilman Brummer, Michael Lübbert, Erika L. Pearce, Franziska M. Uhl, Barbara Sauer, Sophia Chen, Bruce R. Blazar, Geoffroy Andrieux, Robert Zeiser, Annette Schmitt-Graeff, Khalid Shoumariyeh
Publikováno v:
Sci Transl Med
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production.