Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Francesca Blasco"'
Autor:
Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen
Publikováno v:
Antimicrob Agents Chemother
Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/
https://europepmc.org/articles/PMC7674056/
Autor:
Wei Liu, Sreehari Babu, Wai Ling Chan, Suresh B. Lakshminarayana, Ellena Growcott, Peck Gee Seah, Martijn Fenaux, Mei Ding, Nahdiyah Abdul Ghafar, Gang Wang, Ratna Karuna, Cheah Chen Seh, Haoying Xu, Feng Gu, Weidong Zhong, Pei Yong Shi, Keshi Wang, Andrea Leonardi, Francesca Blasco, Yen Liang Chen, Srinivasa P. S. Rao, Siew Pheng Lim, Fumiaki Yokokawa, Jin Zhang
Monophosphate prodrug analogs of 2’-deoxy-2’-fluoro-2’-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue activities in cellular assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d10b314ef2182303dfcf7c75456ce
Publikováno v:
European Journal of Pharmaceutical Sciences. 92:110-116
Lipophilicity is one of the molecular properties assessed in early drug discovery. Direct measurement of the octanol-water distribution coefficient (logD) requires an analytical method with a large dynamic range or multistep dilutions, as the analyte
Autor:
Julien Lescar, Feng Gu, Kah Fei Wan, Francesca Blasco, CongBao Kang, Wai Ling Chan, Wei Liu, Paul W. Smith, Agatha Susila, Bin Zou, Qing Yin Wang, K.L. Yeo, Mei Ding, Chao Shan, Andy M. Yip, Haoying Xu, Hongping Dong, Jing Zou, Suresh B. Lakshminarayana, Ratna Karuna, Pei Yong Shi, Peck Gee Seah
Publikováno v:
Journal of Virology. 89:8233-8244
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that
Autor:
Peter Drueckes, Clive Mccarthy, Catherine H. Régnier, Giorgio Ottaviani, Janitha Reetz, Marc Gerspacher, Fabienne Baffert, Francesca Blasco, Philipp Holzer, Christoph Gaul, Julien Scesa, Eric Vangrevelinghe, Pascal Furet, Carole Pissot-Soldermann, Flavio Ossola, Gisele A. Tavares, Thomas Radimerski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2609-2613
We have designed and synthesized a novel series of 2,8-diaryl-quinoxalines as Janus kinase 2 inhibitors. Many of the inhibitors show low nanomolar activity against JAK2 and potently suppress proliferation of SET-2 cells in vitro. In addition, compoun
Autor:
Raffaello Masciadri, Anke Kurt, Andreas Koblet, Theresa M. Ballard, Pierre-Emmanuel Broutin, Guido Achermann, Porter Richard Hugh Phillip, Francesca Blasco, Frédéric Knoflach, Heinz Stadler, Henner Knust, Peter Hilty, Bernd Büttelmann, Andrew Thomas, Maria-Clemencia Hernandez, Martin Graf, James R. Martin, Holger Fischer, Gerhard Trube, Jürgen Wichmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5746-5752
Through iterative design cycles we have discovered a number of novel new classes where the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine was deemed the most promising GABA(A) alpha5 inverse agonist class with potential for cognitive enhanc
Autor:
Daniel Guthy, Marc Gerspacher, Jasmin Wirth, Robin Alec Fairhurst, Joachim Blanz, Van Huy Luu, Patricia Imbach-Weese, Robert Mah, Christian Schnell, Esther Roehn-Carnemolla, Giorgio Caravatti, Christine Fritsch, Francesca Blasco, Sandrine Desrayaud, Pascal Furet, Dorothee Arz, Mark Knapp
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
A cyclisation within a 4',5-bisthiazole (S)-proline-amide-urea series of selective PI3Kα inhibitors led to a novel 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole tricyclic sub-series. The synthesis and optimisation of this 4,5-dihydrobenzo[1,2-d:3,4-d]bis
Autor:
Ujjini H. Manjunatha, Richard Glynne, John R. Walker, Bee Huat Tan, Paul W. Smith, Srinivasa P. S. Rao, Kelli Kuhen, Pearly Shuyi Ng, Christian G. Noble, Susan W. Barnes, Peter J. Tonge, Seow H. Ng, Suresh B. Lakshminarayana, Ng L. Ma, Ravinder Reddy Kondreddi, Francesca Blasco, Thierry T. Diagana, David Beer, Maxime Herve, Weixuan Yu, Luis R. Camacho
Publikováno v:
Science Translational Medicine. 7
New chemotherapeutic agents are urgently required to combat the global spread of multidrug-resistant tuberculosis (MDR-TB). The mycobacterial enoyl reductase InhA is one of the few clinically validated targets in tuberculosis drug discovery. We repor
Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir
Autor:
Gang Wang, Daniela Cerny, Ratna Karuna, Pei Yong Shi, Fumiaki Yokohama, Feng Gu, Maxime Herve, Siew Pheng Lim, Wouter Schul, Nahdiyah Abdul Ghafar, Yen Liang Chen, Katja Fink, Yilong Fu, Francesca Blasco
Publikováno v:
Journal of virology. 88(3)
In a recent clinical trial, balapiravir, a prodrug of a cytidine analog (R1479), failed to achieve efficacy (reducing viremia after treatment) in dengue patients, although the plasma trough concentration of R1479 remained above the 50% effective conc
Autor:
Igor I. Gerus, Francesca Blasco, Giuseppe Resnati, Valery P. Kukhar, Rosanna Bernardi, Alberto Arnone, Rosanna Cardillo
Publikováno v:
CIÊNCIAVITAE
ResearcherID
ResearcherID
The stereoselective reduction of 3-trifluoromethylcyclohexanone (1a), (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one (3a), and their unfluorinated analogues 1b and 3b has been performed with some growing microorganisms. Differences in the electronic and