Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Enrique Zudaire"'
Autor:
Muhammad Akram, Andrzej Jakubowiak, Nikoletta Lendvai, Samir Parekh, Bertrand Arnulf, H. Einsele, Carolyn C. Jackson, D. Geng, Claire Li, Kevin C. De Braganca, Nwv Donk, MJ Carrasco-Alfonso, Deepu Madduri, Adam B. Cohen, Jaime Gállego Pérez-Larraya, M.V. Mateos, Enrique Zudaire, Yunsi Olyslager, Helen Varsos, Bianca Santomasso
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss, Pp S263-S264 (2021)
Objective Cilta-cel (JNJ-68284528) is a chimeric antigen receptor T cell (CAR-T) therapy with two B-cell maturation antigen (BCMA)-targeting, single-domain antibodies designed to confer high avidity binding. CARTITUDE-2 (NCT04133636) is a phase 2, mu
Autor:
Samir Parekh, Adam B. Cohen, Bertrand Arnulf, Deepu Madduri, Bianca Santomasso, Yunsi Olyslager, Maria-Victoria Mateos, Marlene Carrasco-Alfonso, Carolyn C. Jackson, Enrique Zudaire, Jaime Gállego Pérez-Larraya, Muhammad Akram, Dong Geng, Niels W.C.J. van de Donk, Andrzej Jakubowiak, Helen Varsos, Kevin C. De Braganca, Nikoletta Lendvai, Hermann Einsele, Claire Li
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S421-S422
Context Cilta-cel, a chimeric antigen receptor T (CAR-T) cell therapy with two B-cell maturation antigen (BCMA)-targeting single-domain antibodies demonstrated efficacy in relapsed/refractory multiple myeloma (MM). Objectives To describe mitigation a
Autor:
Xiaoyan M. Zhang, Enrique Zudaire, Brad St. Croix, Karen Morris, Jennifer Hwang, Dean Welsch, Guojun Yu, James M. Dunleavey, Yang Feng, Steven Seaman, Diana C. Haines, Decrescenzo Gary A, Saurabh Saha, Kuo Sheng Hsu, Zhongyu Zhu, Mary Beth Hilton, Christopher S. Szot, Dimiter S. Dimitrov, Deborah A. Swing, Yanping Wang, Amit Chaudhary, Holly Morris
Publikováno v:
Journal of Clinical Investigation. 128:2927-2943
Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for improved cancer therapy are needed. Here, we describe a potent MMAE-linked antibody-drug conjugat
Autor:
Alfredo Martínez, Reuben P. Siraganian, Frank Cuttitta, Enrique Zudaire, Dean D. Metcalfe, Mercedes Garayoa, Gurmeet Kaur, Michael R. Woolhiser, Theresa A. Guise, Ruben Pio, William A. Hook, John M. Chirgwin
Publikováno v:
The American Journal of Pathology. 168:280-291
We have previously demonstrated that adrenomedullin (AM) plays a critical role as an autocrine/paracrine tumor cell survival factor. We now present evidence that AM is an important regulator of mast cell (MC) function and that this modulation is pote
Autor:
Frank Cuttitta, William G. Stetler-Stevenson, Steven K. Libutti, Sergio Portal-Núñez, Enrique Zudaire, Alfredo Martínez, Liliana Guedez
Publikováno v:
Cancer Research. 64:6489-6494
We have found through ex vivo and in vivo angiogenesis models that the adrenomedullin gene-related peptide, proadrenomedullin NH2-terminal 20 peptide (PAMP), exhibits a potent angiogenic potential at femtomolar concentrations, whereas classic angioge
Autor:
Janine Stevens, Enrique Zudaire, Mary Beth Hilton, Daniel Logsdon, Lihong Xu, Holly Morris, Deborah A. Swing, Timothy D. Veenstra, Steven Seaman, Nimit L. Patel, Joseph D. Kalen, Brad St. Croix, Thomas P. Conrads, Diana C. Haines
Publikováno v:
Oncotarget
Anti-angiogenic agents that block Vascular Endothelial Growth Factor (VEGF) signaling are important components of current cancer treatment modalities but are limited by alternative ill-defined angiogenesis mechanisms that allow persistent tumor vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d75a05b986f1772f8597c10d13bd3de
https://europepmc.org/articles/PMC6309995/
https://europepmc.org/articles/PMC6309995/
Autor:
Enrique Zudaire, Frank Cuttitta
Publikováno v:
The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::495ee735379aaee747e5ac5cf23d4680
https://doi.org/10.1007/978-94-007-4581-0
https://doi.org/10.1007/978-94-007-4581-0
Autor:
Marta Aparicio, Gabriela S. Dveksler, Gisela Sulkowski, Enrique Zudaire, Guido David, James Warren, Felipe A. Lisboa
Publikováno v:
The Journal of biological chemistry. 286(9)
Pregnancy-specific β1 glycoproteins (PSGs) are the most abundant fetal proteins in the maternal bloodstream in late pregnancy. They are secreted by the syncytiotrophoblast and are detected around day 14 postfertilization. There are 11 human PSG gene
Publikováno v:
Oncotarget. 5:6556-6557
Cancer chemoprevention employs natural, synthetic, or biologic substances to reverse, suppress, or prevent the development of cancer. Initially these agents were developed to reduce cancer risk or retard its development, but were not intended to trea
Autor:
Laure Gambardella, Bethany Hughes, Enrique Zudaire, Sonja Vermeren, Myriam Hemberger, Simon Andrews
Publikováno v:
Science signaling. 3(145)
One function of phosphoinositide 3-kinase α (PI3Kα), which generates the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)], is its regulation of angiogenesis in the developing embryo and in pathological situations.