Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emma S. Jones"'
Autor:
Brandon A. Kemp, Mark P. Del Borgo, Lucinda M. Hilliard Krause, Robert M. Carey, Robert E Widdop, Marie-Isabel Aguilar, Emma S Jones, Amanda Suan Jui Tan, Kate M. Denton
Publikováno v:
Clinical Science (London, England : 1979)
Recently, we designed a group of peptides by sequential substitution of the naturally occurring α-amino acid throughout the Ang III peptide sequence with the corresponding β-amino acid. β-Amino acid substitution at the proline residue of Ang III (
Autor:
Mark P. Del Borgo, Yan Wang, Pia Elizabeth Walters, Patrick Perlmutter, Marie-Isabel Aguilar, Iresha Spizzo, Lucinda M Hilliard, Robert E Widdop, Emma S Jones, Kate M. Denton, Morimer Khan, Sanja Bosnyak
Publikováno v:
Clinical Science. 129:505-513
We have previously shown that individual β-amino acid substitution in angiotensin (Ang) II reduced Ang II type 1 receptor (AT1R) but not Ang II type 2 receptor (AT2R)-binding and that the heptapeptide Ang III exhibited greater AT2R:AT1R selectivity
Autor:
Sonja Tesanovic Kljajic, Iresha Welungoda, Robert E Widdop, Emma S Jones, Sanja Bosnyak, Tracey Gaspari, Antony Vinh
Publikováno v:
International Journal of Cardiology. 169:281-287
Background The angiotensin II type 2 receptor (AT 2 R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis. Thus this study aimed to determine
Autor:
Sanja Bosnyak, Emma S Jones, Marie-Isabel Aguilar, Arthur Christopoulos, Robert E Widdop, Walter G. Thomas
Publikováno v:
Clinical Science. 121:297-303
AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor) are well known to be involved in the complex cardiovascular actions of AngII (angiotensin II). However, shorter peptide fragments of AngII are thought to have biological activi
Autor:
Walter G. Thomas, Robert E Widdop, Daniel Clayton, Emma S Jones, Nicholas Hausler, Julian Kirsch, Iresha Welungoda, Patrick Perlmutter, Sharon Unabia, Marie-Isabel Aguilar, Mark P. Del Borgo, Sanja Bosnyak
Publikováno v:
Hypertension. 57:570-576
Novel AT 2 R ligands were designed by substituting individual β-amino acid in the sequence of the native ligand angiotensin II (Ang II). Relative ATR selectivity and functional vascular assays (in vitro AT 2 R-mediated vasorelaxation and in vivo vas
Functional Cardiovascular Effects of Angiotensin Peptides: Focus on Atherosclerosis and Hypertension
Publikováno v:
Current Hypertension Reviews. 5:227-236
The renin-angiotensin system (RAS) is a major physiological regulator of body fluid volume, electrolyte balance, and arterial blood pressure. The octapeptide, angiotensin (Ang) II, is the main effector of the RAS and overactivity of Ang II is a major
Autor:
Mark P. Del Borgo, Robert E Widdop, Marie-Isabel Aguilar, Yan Wang, Kate M. Denton, Emma S Jones
This chapter discusses the effects of both endogenous and synthetic peptides in the context of use as AT 2 R agonists. Historically, peptides have often been disregarded for therapeutic development due to their poor in vivo stability and lack of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d834d2ae1887fe5e31630f66fb2b1a88
https://doi.org/10.1016/b978-0-12-801364-9.00019-5
https://doi.org/10.1016/b978-0-12-801364-9.00019-5
Publikováno v:
British Journal of Pharmacology. 140:809-824
It is widely accepted that the angiotensin II type 1 receptor (AT1R) accounts for the majority of cardiovascular effects evoked by angiotensin II (Ang II), such as contraction/pressor activity and growth-promoting effects leading to cardiac and vascu
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 60(1)
See related article, pp 137–144 In recent years there has been a revolution in our knowledge of the renin-angiotensin (Ang) system (RAS), with the identification of novel functions for biologically active Ang peptides and receptors and the discover
Autor:
Norbert Weissmann, David Barit, K. Barthel, Helmut Fuchs, Melanie E. Armitage, Thomas Klopstock, Kirstin Wingler, Christian Geis, Emma S Jones, Alexander M. Herrmann, Michael K. Schuhmann, Tobias Schwarz, Henrike Grund, Christoph Kleinschnitz, Manish Mittal, Anja Schrewe, Peter Kraft, Sabine Meurer, Lore Becker, Harald H.H.W. Schmidt, Sven G. Meuth, Karin Jandeleit-Dahm, Guido Stoll, Valerie Gailus-Durner, Ajay M. Shah, Martin Hrabé de Angelis
Publikováno v:
PLoS Biology, Vol 8, Iss 9 (2010)
PLoS Biol. 8:e1000479 (2010)
Plos Biology, 8(9):e1000479. Public Library of Science
PLoS Biology
PLoS Biol. 8:e1000479 (2010)
Plos Biology, 8(9):e1000479. Public Library of Science
PLoS Biology
The identification of NOX4 as a major source of oxidative stress in stroke and demonstration of dramatic protection after stroke in mice by NOX4 deletion or NOX inhibition, opens up new avenues for treatment.
Ischemic stroke is the second leadin
Ischemic stroke is the second leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f633911ce31e7918ddb714f9dcc23a0
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5641
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5641