Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Denzil Bernard"'
Autor:
Simone Moser, Themistoklis Zisis, Nader Al Danaf, Shuaijun Wang, Angelika M. Vollmar, Don C. Lamb, Sabine Schneider, Maibritt Kretschmer, Ryan P. Pemberton, Stefan Zahler, Cornelia A. Karg, Denzil Bernard
Publikováno v:
Angewandte Chemie. 133:22753-22760
Autor:
Maibritt Kretschmer, Themistoklis Zisis, Denzil Bernard, Simone Moser, Ryan P. Pemberton, Nader Al Danaf, Angelika M. Vollmar, Shuaijun Wang, Cornelia A. Karg, Don C. Lamb, Sabine Schneider, Stefan Zahler
Publikováno v:
Angewandte Chemie (International Ed. in English)
Chlorophyll and heme are among the “pigments of life”, tetrapyrrolic structures, without which life on Earth would not be possible. Their catabolites, the phyllobilins and the bilins, respectively, share not only structural features, but also a s
Autor:
Liu Liu, Krishnapriya Chinnaswamy, Haibin Zhou, Jeanne A. Stuckey, Hong Shen, Chao Yie Yang, Jianfeng Lu, Shaomeng Wang, Donna McEachern, Yi Sun, Denzil Bernard, Liangyou Rui
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cullin-RING E3 ligases (CRLs) regulate the turnover of approximately 20% of mammalian cellular proteins. Neddylation of individual cullin proteins is essential for the activation of each CRL. We report herein the discovery of DI-1548 and DI-1859 as t
Autor:
Fangyang Wang, Tycel Phillips, Sami N. Malek, Shaomeng Wang, Denzil Bernard, Shilin Xu, Zhengfan Xu, Sumana Devata, Jing Zhang, Nan Hu, Mark S. Kaminski, Tianyu Sun
Publikováno v:
Clinical Cancer Research. 27:2301-2313
Purpose: On the basis of the recent discovery of mutations in Bruton tyrosine kinase (BTK) in follicular lymphoma, we studied their functional properties. Experimental Design: We identified novel somatic BTK mutations in 7% of a combined total of 139
Autor:
M. Kyle Hadden, Anna Hakey, Young Tang, Radha Charan Dash, Chang Huang, Antonio E. Garmendia, Denzil Bernard, Alexander Chu, Alec Knupp, Jiaqi Zhu
Publikováno v:
Virology Journal
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the pork industry globally. PRRS is caused by PRRS virus (PRRSV). Currently there are no effective treatments against this
Autor:
Haibin Zhou, Mi Wang, Shirley Y. Lee, Yali Dou, Jeanne A. Stuckey, Elyse Petrunak, Shaomeng Wang, Ting-Rong Chern, Denzil Bernard, Liu Liu
Publikováno v:
ACS Med Chem Lett
[Image: see text] The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a2e3ad5fa669657b23841b5ea27ce8
https://europepmc.org/articles/PMC7294728/
https://europepmc.org/articles/PMC7294728/
Autor:
Denzil Bernard, Sally Przybranowski, Jeanne A. Stuckey, Donna McEachern, Tianfeng Xu, Ke Zheng, Ester Fernandez-Salas, Liyue Huang, Krishnapriya Chinnaswamy, Liu Liu, Mi Wang, Shaomeng Wang, Caroline Foster, Shilin Xu, Angelo Aguilar
Publikováno v:
Angewandte Chemie International Edition. 57:1601-1605
The structure-based design of M-525 as the first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction is presented. M-525 targets cellular menin protein at sub-nanomolar concentrations and achieves low nanomolar
Autor:
Stephanie Layton, Weihua Zhou, Liu Liu, Zhen-Qiang Pan, Krishnapriya Chinnaswamy, Chao Yie Yang, Jeanne A. Stuckey, Shaomeng Wang, Haibin Zhou, Jianfeng Lu, Denzil Bernard, Ester Fernandez-Salas, Yi Sun, Qing Yu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of ~20% of cellular proteins and their activation require neddylation of their cullin subunit. Cullin neddylation is modulated by a scaffolding DCN protein through interactions with bot
Autor:
Guangfeng Wang, Duxin Sun, Ruijuan Luo, Ming Guo, Jianfeng Wen, Yifan Zhai, Sally Przybranowski, Bo Wen, Donna McEachern, Shaomeng Wang, Angelo Aguilar, Ding Du, Liu Liu, Jianfeng Lu, Xiaoqin Li, Denzil Bernard, Dajun Yang, Hengbang Wang
Publikováno v:
Journal of Medicinal Chemistry
We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this paper we describe an extensive structure–activity relationship study of this class of MDM
Autor:
Shaomeng Wang, Denzil Bernard, Shilin Xu, James Delproposto, Ester Fernandez-Salas, Liyue Huang, Kaitlin Harvey, Jeff W. Kampf, Liu Liu, Angelo Aguilar, Jeanne A. Stuckey, Tianfeng Xu, Caroline Foster, Donna McEachern, Ke Zheng, Krishnapriya Chinnaswamy
Publikováno v:
J Med Chem
Inhibition of the menin-mixed lineage leukemia (MLL) protein-protein interaction is a promising new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein our structure-based design, synthesis,