Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christoph W. Grathwol"'
Autor:
Sascha Grobe, Thomas Bayer, Emil Hamnevik, Sven Koban, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Christoph W. Grathwol, Christoffel P. S. Badenhorst, Andreas Link, Henrike Brundiek
Publikováno v:
Angewandte Chemie (International Ed. in English)
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo‐ and regioselective 7β‐hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydro
Autor:
Christoffel P. S. Badenhorst, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Sven Koban, Thomas Bayer, Henrike Brundiek, Christoph W. Grathwol, Sascha Grobe, Emil Hamnevik, Andreas Link
Publikováno v:
Angewandte Chemie. 133:764-768
Autor:
Christoph W. Grathwol, Klaus Weisz, Yoanes Maria Vianney, Andreas Link, Qingyun Tang, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
ChemCatChem. 12:3721-3727
Methylation of free hydroxyl groups is an important modification for flavonoids. It not only greatly increases absorption and oral bioavailability of flavonoids, but also brings new biological activities. Flavonoid methylation is usually achieved by
Autor:
Christian Bock, Andreas Link, Robert K. Hofstetter, Werner Siegmund, Felix Potlitz, Abdrrahman Shemsu Surur, Georg M. Fassauer, Tobias Oergel, Christoph W. Grathwol, Mahmoud Hasan, Steven Behnisch
Publikováno v:
Journal of Chromatography A. 1603:338-347
Supercritical fluid chromatography (SFC) holds the potential to become an orthogonal method to HPLC/UHPLC in xenobiotic metabolism studies, due to its outstanding capacity to simultaneously separate highly similar (as HPLC) and physicochemically diff
Autor:
Robert K. Hofstetter, Andreas Link, Nathalie Wössner, Manfred Jung, Anja Bodtke, Adam C. Smith, Christoph W. Grathwol, Enrico Tapavicza, Sören Swyter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2170-2183 (2019)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound
Autor:
Qingyun Tang, Christoph W. Grathwol, Shuke Wu, Christoffel P. S. Badenhorst, Andreas Link, Aşkın S. Aslan-Üzel, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently sh
Autor:
Lukas Schulig, Andreas Link, Nathalie Wössner, Steven Behnisch‐Cornwell, Christoph W. Grathwol, Manfred Jung, Oliver Einsle, Lin Zhang
Publikováno v:
Chemmedchem
Because isoenzymes of the experimentally and therapeutically extremely relevant sirtuin family show high similarity, addressing the unique selectivity pocket of sirtuin 2 is a promising strategy towards selective inhibitors. An unrelated approach tow
Autor:
Sören Swyter, Nathalie Wössner, Enrico Tapavicza, Anja Bodtke, Manfred Jung, Robert K. Hofstetter, Adam C. Smith, Christoph W. Grathwol, Andreas Link
The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. In this context, aromatic diazeno compounds are well suited for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae121125c7cddec7ad289a831a587d2
https://doi.org/10.3762/bxiv.2019.53.v1
https://doi.org/10.3762/bxiv.2019.53.v1
Autor:
Christoph W. Grathwol, Qingyun Tang, Christoffel P. S. Badenhorst, Ioannis V. Pavlidis, Uwe T. Bornscheuer, Shuke Wu, Andreas Link, Aşkın S. Aslan-Üzel
Publikováno v:
Angewandte Chemie