Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Cheryl H. Arrowsmith"'
Autor:
Yunhuang Yang, Michael A. Kennedy, Adelinda Yee, Cheryl H. Arrowsmith, John R. Cort, Maite Garcia, Theresa A. Ramelot
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 6, Pp 7354-7364 (2012)
CV_2116 is a small hypothetical protein of 82 amino acids from the Gram-negative coccobacillus Chromobacterium violaceum. A PSI-BLAST search using the CV_2116 sequence as a query identified only one hit (E = 2e−07) corresponding to a hypothetical p
Externí odkaz:
https://doaj.org/article/40d46b6009384dd49c7ee22d66c8949f
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Autor:
Rachel Harding, M.K. Mann, Ahmed Aman, Carlos Zepeda-Velázquez, Brian J. Wilson, Taira Kiyota, Cheryl H. Arrowsmith, Peter Loppnau, Rima Al-awar, Matthieu Schapira, Héctor González-Álvarez, Yanjun Li, Aiping Dong
Publikováno v:
Journal of Medicinal Chemistry. 64:15017-15036
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Autor:
Aiping Dong, Levon Halabelian, Cheryl H. Arrowsmith, Yanjun Li, Ute Kothe, Hong Zeng, Hong Wu, Julia Guegueniat
Publikováno v:
Nucleic Acids Research
Nucleic Acids Res
Nucleic Acids Res
The human pseudouridine synthase PUS7 is a versatile RNA modification enzyme targeting many RNAs thereby playing a critical role in development and brain function. Whereas all target RNAs of PUS7 share a consensus sequence, additional recognition ele
Autor:
Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown
Publikováno v:
SLAS Discovery. 26:947-960
SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate and regulate several nonhist
Autor:
Jian Jin, Levon Halabelian, Fengling Li, Masoud Vedadi, Rima Al-awar, Carlo C. dela Seña, Mohammad S. Eram, Aiping Dong, Carlos Zepeda-Velázquez, He Chen, Matthieu Schapira, Robert M. Campbell, Dalia Barsyte-Lovejoy, David McLeod, Cheryl H. Arrowsmith, Hong Zeng, Hong Wu, Yudao Shen, Mary M. Mader, Viacheslav V. Trush, Brian Morgan Watson, Kwang-Su Park, Irene Chau, Fanye Meng, Peter Brown, H. Ümit Kaniskan, Magdalena M. Szewczyk
Publikováno v:
J Med Chem
Protein arginine methyltransferase 6 (PRMT6) catalyzes monomethylation and asymmetric dimethylation of arginine residues in various proteins, plays important roles in biological processes, and is associated with multiple cancers. To date, a highly se
Autor:
Jing Liu, Dalia Barsyte-Lovejoy, Aiping Dong, Kwang-Su Park, Fanye Meng, Irene Chau, Jian Jin, Peter Brown, Levon Halabelian, Yudao Shen, He Chen, Fengling Li, Cheryl H. Arrowsmith, Masoud Vedadi, Magdalena M. Szewczyk, Hong Zeng
Publikováno v:
J Med Chem
Protein arginine methyltransferase 6 (PRMT6) plays important roles in several biological processes associated with multiple cancers. Well-characterized potent, selective, and cell-active PRMT6 inhibitors are invaluable tools for testing biological an
Autor:
S. Velupillai, Udo Oppermann, Irene Chau, Ruth Faram, Andrew M. Lewis, Jessica Malzahn, Yan Xiong, Cheryl H. Arrowsmith, Masoud Vedadi, Nicholas A. Athanasou, Abdellah Allali-Hassani, Holger Greschik, Octovia P. Monteiro, Fengling Li, Carina Gileadi, Reshma Nibhani, Graham Wells, C. Bountra, Thomas Christott, Vincent Fagan, Catrine Johansson, Roland Schüle, Nadia Halidi, Martin Philpott, Manfred Jung, Paul Brennan, Oleg Fedorov, Kilian Huber, Adam P. Cribbs, Charline Giroud, James E. Dunford, Jian Jin, Jim Bennett, Gillian Farnie
Publikováno v:
Journal of Medicinal Chemistry. 62:9008-9025
Modifications of histone tails, including lysine/arginine methylation, provide the basis of a 'chromatin or histone code'. Proteins that con-tain 'reader' domains can bind to these modifications and form specific effector complexes, which ultimately
Autor:
Ashley Hutchinson, Francois Benard, Sriram Subramaniam, Karoline Leopold, Ruiyan Tan, Cheryl H. Arrowsmith, Dhiraj Mannar, Serap Beldar, Daniel Kwon, Almagul Seitova, Yanjun Li, Bryan J Fraser, Levon Halabelian, Ryan P Wilson
Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell factor for viral entry and pathogenesis of SARS-coronavirus-2 (SARS-CoV-2). Specifically, TMPRSS2 proteolytically processes the SARS-CoV-2 Spike (S) Protein, enabling vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99cf15a2225ecd0399df868c89764faa
https://doi.org/10.1101/2021.06.23.449282
https://doi.org/10.1101/2021.06.23.449282
Autor:
Rima Al-awar, Taira Kiyota, Matthieu Schapira, M.K. Mann, Carlos Zepeda-Velázquez, Rachel Harding, Ahmed Aman, Cheryl H. Arrowsmith, H.G. Alvarez, A. Dong
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384a9b2f5329ddc45417c141a66ae99d
https://doi.org/10.1101/2021.05.17.444542
https://doi.org/10.1101/2021.05.17.444542