Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Charles R. Mackay"'
Autor:
Juliana Echevarria-Lima, Leandro Araujo Lobo, Charles R. Mackay, Dario S. Zamboni, Robson Coutinho-Silva, Ana Carolina Oliveira, Julio Scharfstein, Regina Maria Cavalcanti Pilotto Domingues, Aline Cristina Abreu Moreira-Souza, Eliana Mariño, Erivan Schnaider Ramos-Junior, Maria Bellio, Eliane de Oliveira Ferreira, Juliana P Castelpoggi, Bruno Jennings-Almeida
Publikováno v:
The Journal of Immunology. 206:2441-2452
Intestinal barrier is essential for dietary products and microbiota compartmentalization and therefore gut homeostasis. When this barrier is broken, cecal content overflows into the peritoneal cavity, leading to local and systemic robust inflammatory
Autor:
Matthew Snelson, Gavin W. Lambert, Assam El-Osta, Grant R Drummond, D. Donner, Melinda T. Coughlan, Helen Kiriazis, Aanthony Vinh, Duncan Horlock, Charles R. Mackay, Waled A. Shihata, Hamdi A. Jama, Beverly Giam, Tim D. Spector, Chad Johnson, Mark Ziemann, Xiao-Jun Du, April Fiedler, Kirill Tsyganov, Francine Z. Marques, David M. Kaye, Sarah E. Phillips, Amrita Vijay, Ana M. Valdes
Publikováno v:
Circulation. 141:1393-1403
Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lac
Autor:
Madeleine Paterson, Evany Dinakis, Liang Xie, Ekaterina Salimova, Charles R. Mackay, Francine Z Marques, Caroline Ang, Hamdi A. Jama, Rikeish R. Muralitharan, Michael E Nakai, Alex Cheng Guan Peh, Remy Robert
Publikováno v:
Hypertension. 78
High fibre (HF) diet protects against hypertension via the production of acidic metabolites, e.g. short-chain fatty acids, by the gut microbiota. While these metabolites have a direct role in blood pressure (BP) regulation, their acidic nature may ac
Autor:
Joanne O'Donnell, Christopher K. Barlow, Charles R. Mackay, Maria Kaparakis-Liaskos, Rikeish R. Muralitharan, Michael E Nakai, Evany Dinakis, Chudan Xu, Madeleine Paterson, Ekaterina Salimova, Natalie J. Bitto, Francine Z Marques, Darren Creek, Hamdi A. Jama, Liang Xie
Publikováno v:
Hypertension. 78
High dietary fibre is fermented by the gut microbiota, resulting in the release of metabolites called short-chain fatty acids (SCFAs). Both fibre and SCFAs can reduce high blood pressure (BP) and its associated cardio-renal complications. However, th
Autor:
Melinda T. Coughlan, Waled A. Shihata, Louise M Burrell, Charles R. Mackay, Francine Z. Marques, Rikeish R. Muralitharan, Michael E Nakai, Matthew Snelson, David M. Kaye, Hamdi A. Jama, Chad Johnson, Evany Dinakis
Publikováno v:
Hypertension. 77
Autor:
Duan Ni, Alexandra Sophie Angelatos, Charles R. Mackay, M.C.B. Amian, Claire Daien, Stephen J. Simpson, Remy Robert, M. Duraes, Jian Tan, S. Hoque, Alison K. Gosby, Rosilene V Ribeiro, Lake-Ee Quek, R. Audo, J. Mielle, Gabriela Pinget, A. Parmar, M.J. Alam, Laurence Macia, Frederic Sierro, James R. Krycer, G. Perkins
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight, Vol 6, Iss 7 (2021)
Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and pro
Autor:
Charles R. Mackay, Véronique J. Moulin, Mark Slevin, Lucas Felipe Fernandes Bittencourt, Pollyana Ribeiro Castro, Lucíola S. Barcelos, SP Silvia Passos Andrade Andrade, Sébastien Larochelle
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 320(3)
Butyrate is a short-chain fatty acid (SCFA) derived from microbiota and is involved in a range of cell processes in a concentration-dependent manner. Low concentrations of sodium butyrate (NaBu) were shown to be proangiogenic. However, the mechanisms
Autor:
Karina R. Bortoluci, Sílvio Roberto Consonni, Marcella Rungue, Charles R. Mackay, Jaqueline de Souza Felipe, Brian T. Layden, Cristiane Sécca, Niels Olsen Saraiva Câmara, Laís Passariello Pral, Fabio Takeo Sato, Hosana G. Rodrigues, Ulliana Marques Sampaio, José Luís Fachi, Marco Colonna, Victor de Melo Rocha, Blanda Di Luccia, Patrícia Brito Rodrigues, Maria Teresa Pedrosa Silva Clerici, Angélica T. Vieira, Felipe Cezar Pinheiro de Mato, Marco Aurélio Ramirez Vinolo, Sergio C. Oliveira
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine
Microbiota-derived acetate coordinates innate immune responses during intestinal Clostridium difficile infection through its cognate receptor FFAR2. Acetate accelerates early neutrophil recruitment and increases ILC3 expression of the IL-1 receptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3bce01b261d6fe3ea8a3e60a3a1594
Autor:
Charles R. Mackay, Hamdi A. Jama, Kirill Tsyganov, Gavin W. Lambert, D. Donner, Helen Kiriazis, Grant R Drummond, Sarah E. Phillips, Chad Johnson, Francine Z. Marques, Duncan Horlock, Waled A. Shihata, Antony Vinh, April Fiedler, Mark Ziemann, David M. Kaye, Matthew Snelson, Sam El-Osta, Beverly Giam, Xiao-Jun Du
Publikováno v:
Hypertension. 74
Background: High fibre intake is associated with lower blood pressure (BP) in epidemiological and clinical studies. Prebiotic fibre resists digestion in the upper gastrointestinal tract and is fermented by gut microbiota in the intestine. The impact
Autor:
Wenyan Wang, Yiping Li, Xiaohuan Guo, Charles R. Mackay, Jiaoyan Huang, Xin Dong, Yun Chen, Yang Xin Fu, Yao He, Quanbo Wang, Liuhui Fu, Jing Zhang, Mingli Gong
Publikováno v:
Cell Metabolism. 33:988-1000.e7
Summary Recent studies in both mice and humans have suggested that gut microbiota could modulate tumor responsiveness to chemo- or immunotherapies. However, the underlying mechanism is not clear yet. Here, we found that gut microbial metabolites, esp