Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Subhajit Roy, Punnag Saha, Dipro Bose, Ayushi Trivedi, Madhura More, Shuo Xiao, Anna Mae Diehl, Saurabh Chatterjee
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16354 (2023)
Harmful algal bloom toxin microcystin has been associated with metabolic dysfunction-associated steatotic liver disease (MASLD) progression and hepatocellular carcinoma, though the mechanisms remain unclear. Using an established mouse model of MASLD,
Externí odkaz:
https://doaj.org/article/2cb1c072b92a496fb50577016098a517
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 6, p 857 (2016)
Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease in the Western world. Although only a minority of patients will ultimately develop end-stage liver disease, it is not yet possible to efficiently predict who w
Externí odkaz:
https://doaj.org/article/9422416e62b743c7a83360a55fa261a0
Gut-microbiome-inflammation interactions have been linked to neurodegeneration in Alzheimer’s disease (AD) and other disorders. We hypothesized that treatment with rifaximin, a minimally absorbed gut-specific antibiotic, may modify the neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58ad9f91d26fec40bbc761a4d35564a
https://doi.org/10.1101/2021.11.22.21266123
https://doi.org/10.1101/2021.11.22.21266123
Autor:
Anna Mae Diehl, Ning-Ping Zhang, Ying Wang, Chen Yang, Xiuping Liu, Xue-Jing Liu, Wen‐Yue Dong, Chang Liu, Li Xie, Manal F. Abdelmalek, Jian Wu, Chenjian Gu, Kuo Du, Chen Niu
Publikováno v:
Liver Int
Background and aims Treatment of non-alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigat
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
Valentin Gogonea, George D. Dalton, Amanda L. Brown, Anna Mae Diehl, Seh-Hoon Oh, Stephanie Zhang, Preeti Pathak, Camelia Baleanu-Gogonea, Linda Tang, Venkateshwari Varadharajan, J. Mark Brown
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103089-(2021)
Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sens
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Autor:
Andrea G. Nackley, Wolfgang Liedtke, Anna Mae Diehl, Huiping Ding, Andreas E. Kremer, Johannes Morstein, Ana E. López-Romero, Qian Zeng, Zilong Wang, Ru-Rong Ji, Qiaojuan Zhang, Yong Chen, Xin Zhang, Piotr Milkiewicz, Tony E. Reeves, Sara L. Morales-Lázaro, Jennifer Y. Zhang, Marcin Krawczyk, Tamara Rosenbaum, Mei-Chuan Ko, Frank Lammert, Andrey V. Bortsov, Manal F. Abdelmalek, Michele Yeo, Huanghe Yang, Carlene Moore, Ying-Ai Jin
Publikováno v:
Gastroenterology. 161(1)
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Meth
Autor:
Ying Wang, Cynthia D. Guy, Cynthia A. Moylan, Anna Mae Diehl, Catherine F. Howe, Manal F. Abdelmalek, Ricardo Henao, Kara Wegermann
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Identifying patients at higher risk for poor outcomes from nonalcoholic fatty liver disease (NAFLD) remains challenging. Metabolomics, the comprehensive measurement of small molecules in biological samples, has the potential to reveal novel noninvasi
Autor:
Jason Gibson, David S. Hsu, Jeongeun Hyun, Anna Mae Diehl, Simon G. Gregory, Richard T. Premont, Cynthia D. Guy, Mark L. Jewell, Kuo Du, Seh-Hoon Oh, Thomas J. Ribar
Publikováno v:
Am J Pathol
Fibrolamellar carcinoma (FLC) is characterized by in-frame fusion of DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1) with protein kinase cAMP-activated catalytic subunit α (PRKACA) and by dense desmoplasia. Surgery is the only effective tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7b8fb52946e0d6a93a78c380043659
https://europepmc.org/articles/PMC10069284/
https://europepmc.org/articles/PMC10069284/