Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Publikováno v:
Biochemical Pharmacology. 164:336-341
Hypercholesterolemia represents a leading cause in the development of atherosclerotic plaques, increasing the risk for ACVS. It actually counts as a major cause of cardiovascular disease etiopathogenesis. The causes of hypercholesterolemia are multif
Autor:
Fatemeh Momen-Heravi, Hiroshi Nakagawa, Satoshi Takada, Veena Sangwan, Norihiro Matsuura, Andres J. Klein-Szanto, Angela J. Yoon, Koji Tanaka, Samuel Flashner, Uma M. Sachdeva, Lorenzo E. Ferri, Masataka Shimonosono, Eishi Noguchi, J. Alan Diehl, Yasuto Tomita
Publikováno v:
Biomolecules, Vol 11, Iss 1479, p 1479 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Background: Alcohol (ethanol) consumption is a major risk factor for head and neck and esophageal squamous cell carcinomas (SCCs). However, how ethanol (EtOH) affects SCC homeostasis is incompletely understood. Methods: We utilized three-dimensional
Autor:
Tiffany Luong, Kathy Q. Cai, Débora Barbosa Vendramini-Costa, Andres J. Klein-Szanto, Huamin Wang, Kerry S. Campbell, Janusz Franco-Barraza, Edna Cukierman, Ralph Francescone, Igor Astsaturov
Publikováno v:
Cancer Research. 81:116-116
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly types of cancer, with a 5-year survival of only 10%. One of the major features of PDAC is the dense fibrous stroma, due to the expansion of cancer associated fibroblasts (CAFs) and the
Autor:
Janusz Franco-Barraza, Débora Barbosa Vendramini-Costa, Igor Astsaturov, Andres J. Klein-Szanto, Tiffany Luong, Ralph Francescone, Kerry S. Campbell, Edna Cukierman, Huamin Wang, Kathy Q. Cai
Publikováno v:
Cancer Research. 81:LT019-LT019
Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, features a highly immunosuppressive environment, with expansion of cancer-associated fibroblasts (CAFs), and absence/inactivation of antitumor immune cells. Therefore, ways to man
Autor:
Jennifer R. Pyle, V. Craig Jordan, Andres J. Klein-Szanto, Helen Kim, Joan S. Lewis-Wambi, Chris Wambi, Roshani R. Patel
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-3 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired
Autor:
Manti Guha, Prasanna M. Chandramouleeswaran, Andres J. Klein-Szanto, James Garifallou, Clementina Mesaros, Hiroshi Nakagawa, Renata Pellegrino da Silva, Ian A. Blair, Noah Engel, Eishi Noguchi, Joseph A. Baur, Masataka Shimonosono, Hakon Hakonarson, Uma M. Sachdeva, Gordon Ruthel, Michael Gonzalez, Shinya Ohashi, Hisatsugu Maekawa, Kelly A. Whelan, Sarmistha Mukherjee
Publikováno v:
BASE-Bielefeld Academic Search Engine
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While
Autor:
Angela J. Yoon, Takashi Kijima, J. Alan Diehl, Hisatsugu Maekawa, Koji Tanaka, Satoshi Takada, Elizabeth Philipone, Manti Guha, Adam J. Bass, Andres J. Klein-Szanto, Anil K. Rustgi, Varun Sahu, Masataka Shimonosono, Hiroshi Nakagawa
Publikováno v:
Cancer Research. 80:501-501
Introduction: Heavy alcohol (EtOH) drinking and tobacco smoking increase the risk for upper digestive (e.g. oral and esophageal) squamous cell carcinomas (SCC) in individuals with polymorphic mutations in aldehyde dehydrogenase 2 (Aldh2). Mutant Aldh
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes