Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Amanda, Taylor"'
Publikováno v:
J Neurophysiol
Functional magnetic resonance imaging (fMRI) measures blood-oxygen-level-dependent (BOLD) contrast that is generally assumed to be linearly related to excitatory neural activity. The positive hemodynamic response function (pHRF) is the positive BOLD
Autor:
Steven Thompson, Alex Klarer, David Smith, Steve Charlebois, Amanda Taylor, Hayley Steidinger
Publikováno v:
Cell and Gene Therapy Insights. 6:287-294
Autor:
Steven Mennerick, Kathiresan Krishnan, Mingxing Qian, Xiaoping Jiang, Charles F. Zorumski, Amanda Taylor, Hong-Jin Shu, Douglas F. Covey
Publikováno v:
Neuropharmacology. 108:193-206
Anesthetic, GABA-active neurosteroids potently augment GABAA receptor function, leading to important behavioral consequences. Neurosteroids and their synthetic analogues are also models for a wide variety of cell-permeant neuroactive compounds. Cell
Autor:
James J. Doherty, Jayaram Mohan, Christine M. Emnett, Steven Mennerick, Charles F. Zorumski, Amanda Taylor, Lawrence N. Eisenman, Steven M. Paul
Publikováno v:
British Journal of Pharmacology. 172:1333-1347
Background and Purpose Memantine and ketamine are clinically used, open-channel blockers of NMDA receptors exhibiting remarkable pharmacodynamic similarities despite strikingly different clinical profiles. Although NMDA channel gating constitutes an
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174416 (2017)
PLoS ONE
PLoS ONE
N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death. Unfortunately, undesired side effects have limited the strategy of in
Publikováno v:
Psychopharmacology. 231:3493-3501
Neurosteroids and likely other lipid modulators access transmembrane sites on the GABAA receptor (GABAAR) by partitioning into and diffusing through the plasma membrane. Therefore, specific components of the plasma membrane may affect the potency or
Autor:
Eva Kudova, George Elias, Alex S. Evers, Mingxing Qian, Charles F. Zorumski, Amanda Taylor, Brad D. Manion, Gustav Akk, Douglas F. Covey, Kathiresan Krishnan, Ping Li, Steven Mennerick
Publikováno v:
Journal of Medicinal Chemistry. 57:171-190
A model of the alignment of neurosteroids and ent-neurosteroids at the same binding site on γ-aminobutyric acid type A (GABAA) receptors was evaluated for its ability to identify the structural features in ent-neurosteroids that enhance their activi
Autor:
Douglas F. Covey, Achintya K. Bandyopadhyaya, Nigam P. Rath, Steven Mennerick, Charles F. Zorumski, Amanda Taylor, Alex S. Evers, Brad D. Manion, Ann Benz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6680-6684
Alphaxalone, a neuroactive steroid containing a 17β-acetyl group, has potent anesthetic activity in humans. This pharmacological activity is attributed to this steroid's enhancement of γ-amino butyric acid-mediated chloride currents at γ-amino but
Autor:
H-J Shu, Joseph H. Steinbach, Steven Mennerick, Mariangela Chisari, Charles F. Zorumski, Amanda Taylor
Publikováno v:
British Journal of Pharmacology. 160:130-141
Background and purpose: Some neurosteroids, notably 3α-hydroxysteroids, positively modulate GABAA receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulat
Autor:
Steven Mennerick, Kathiresan Krishnan, Achintya K. Bandyopadhyaya, Amanda Taylor, Cunde Wang, Douglas F. Covey, Hong-Jin Shu, Charles F. Zorumski, Alex S. Evers, Brad D. Manion, Ann Benz, Lawrence N. Eisenman
Publikováno v:
Molecular Pharmacology. 76:754-765
We have shown that fluorescent, 7-nitro-2,1,3-benzoxadiazol-4-yl amino (NBD)-conjugated neurosteroid analogs photopotentiate GABA(A) receptor function. These compounds seem to photosensitize a modification of receptor function, resulting in long-live