Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alkhalil, M"'
Publikováno v:
Organic Letters. 23:3259-3263
Monofluoroalkenes normally act as metabolically stable bioisosteres for amide groups (-NH-CO-) and have widespread applications in drug discovery. Additionally, they are widely used as building blocks in organic synthesis. In this study, the Cu/Pd-ca
Publikováno v:
Chemical Communications. 57:6400-6403
Borylative difunctionalization of alkenes has emerged as a powerful approach for synthesizing highly functionalized molecules. Herein, dual Cu/Pd-catalysed borylfluoroallylation of alkenes was smoothly achieved by using gem-difluorinated cyclopropane
Publikováno v:
Organic Letters. 22:1414-1419
Herein, we describe a palladium-catalyzed alkynylation of gem-difluorinated cyclopropanes via C–C bond activation/C–F bond cleavage, followed by C–C(sp) coupling. The new approach proceeds with broad substrate scope under mild reaction conditio
Publikováno v:
Organic Letters. 21:5645-5649
A palladium-catalyzed cross-coupling of gem-difluorinated cyclopropanes with boronic acids, providing the corresponding arylated/alkenylated/alkylated 2-fluoroallylic scaffolds, is generated. This new approach has good functional group compatibility
Autor:
Hong-Ping Xiao, Hongxin Liu, Jun Jiang, Ebrahim-Alkhalil M. A. Ahmed, Xingen Hu, Juan Li, Lingchen He
Publikováno v:
The Journal of organic chemistry. 86(6)
We described a Ni-bidentate oxazoline catalyzed highly enantio- and diastereoselective decarboxylative aldol reaction of 2-oxotetrahydrofuran-3-carboxylic acid/2-oxochromane-3-carboxylic acid derivatives with different kinds of carbonyls. Under optim
Autor:
Yun-Long Wang, Qianqian Lu, Yao Fu, Chu-Guo Yu, Ebrahim-Alkhalil M. A. Ahmed, Bin Xiao, Jun Xu
Publikováno v:
Angewandte Chemie International Edition. 54:8231-8235
An unprecedented Pd-catalyzed regioselective activation of gem-difluorinated cyclopropanes induced by C-C bond cleavage is reported. It provides a general and efficient access to a variety of 2-fluoroallylic amines, ethers, esters, and alkylation pro
Publikováno v:
Chemical communications (Cambridge, England). 53(5)
We report the first copper-catalyzed/mediated borylative ring opening reaction of epoxides. This process represents a direct borylative C(sp3)–O bond cleavage of terminal epoxide substrates with commercially available diboron reagents. A wide range
Autor:
Yao Fu, Jun Xu, Qianqian Lu, Ebrahim-Alkhalil M. A. Ahmed, Bin Xiao, Chu-Guo Yu, Yun-Long Wang
Publikováno v:
ChemInform. 46
A variety of 2-fluoroallylic amines, ethers, esters, and alkylation products are efficiently obtained with high Z-selectivity through regioselective activation of gem-difluorinated cyclopropanes induced by C—C bond cleavage.