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Autor:
Christian Østergaard Mariager, Niels Jessen, Rasmus Stilling Tougaard, Christoffer Laustsen, Hans Stødkilde-Jørgensen, Mads Dam Lyhne, Nikolaj Rittig, Mads Bengtsen, Esben Søvsø Szocska Hansen, Niels Møller, Julie Støy
Publikováno v:
Bengtsen, M B, Hansen, E S S, Tougaard, R S, Lyhne, M D, Rittig, N F, Støy, J, Jessen, N, Mariager, C Ø, Stødkilde-Jørgensen, H, Møller, N & Laustsen, C 2021, ' Hyperpolarized [1-13 C]pyruvate combined with the hyperinsulinaemic euglycaemic and hypoglycaemic clamp technique in skeletal muscle in a large animal model ', Experimental Physiology, vol. 106, no. 12, pp. 2412-2422 . https://doi.org/10.1113/EP089782
New Findings: What is the central question of this study? Is it possible to combine the hyperpolarized magnetic resonance technique and the hyperinsulinaemic clamp method in order to evaluate skeletal muscle metabolism in a large animal model? What i
Autor:
Mathias Laustsen Jensen, Rasoul Mahshid, Greta D’Angelo, Jeppe U. Walther, Malte K. Kiewning, Jon Spangenberg, Hans Nørgaard Hansen, David Bue Pedersen
Publikováno v:
Applied Sciences, Vol 9, Iss 19, p 4168 (2019)
This paper introduces two new deposition-strategies for five degrees of freedom (5DOF) and 6DOF extrusion-based additive manufacturing (AM), called the tool path projection- and parent-child-approach, respectively. The tool path projection method can
Externí odkaz:
https://doaj.org/article/1513594f97bd4550816f6d8e58db45c9
Autor:
Marco A. Sartim, Maria Cristina Nonato, Suely Vilela Sampaio, Gisele Adriano Wiezel, Shirin Ahmadi, Eliane Candiani Arantes, Konstantinos Kalogeropoulos, Karla de Castro Figueiredo Bordon, Andreas Hougaard Laustsen, Isadora Sousa de Oliveira, Dominique Baiwir, Loïc Quinton, Ulrich auf dem Keller, Manuela Berto Pucca, Iara Aimê Cardoso
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
de Oliveira, I S, Pucca, M B, Wiezel, G A, Cardoso, I A, de Castro Figueiredo Bordon, K, Sartim, M A, Kalogeropoulos, K, Ahmadi, S, Baiwir, D, Nonato, M C, Sampaio, S V, Laustsen, A H, auf dem Keller, U, Quinton, L & Arantes, E C 2021, ' Unraveling the structure and function of Cdc PDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom ', International Journal of Biological Macromolecules, vol. 178, pp. 180-192 . https://doi.org/10.1016/j.ijbiomac.2021.02.120
Universidade de São Paulo (USP)
instacron:USP
de Oliveira, I S, Pucca, M B, Wiezel, G A, Cardoso, I A, de Castro Figueiredo Bordon, K, Sartim, M A, Kalogeropoulos, K, Ahmadi, S, Baiwir, D, Nonato, M C, Sampaio, S V, Laustsen, A H, auf dem Keller, U, Quinton, L & Arantes, E C 2021, ' Unraveling the structure and function of Cdc PDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom ', International Journal of Biological Macromolecules, vol. 178, pp. 180-192 . https://doi.org/10.1016/j.ijbiomac.2021.02.120
This study reports the isolation, structural, biochemical, and functional characterization of a novel phosphodiesterase from Crotalus durissus collilineatus venom (CdcPDE). CdcPDE was successfully isolated from whole venom using three chromatographic
Autor:
Mette Ji Riis-Vestergaard, Peter Breining, Steen Bønløkke Pedersen, Christoffer Laustsen, Hans Stødkilde-Jørgensen, Per Borghammer, Niels Jessen, Bjørn Richelsen
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2597 (2018)
The capacity to increase energy expenditure makes brown adipose tissue (BAT) a putative target for treatment of metabolic diseases such as obesity. Presently, investigation of BAT in vivo is mainly performed by fluoro-d-glucose positron emission tomo
Externí odkaz:
https://doaj.org/article/b6d2352843c04ae9bfb7113198d405f6
Publikováno v:
Beck, K M, L. Pham, R, A. Nanim, R, Laustsen, A & Nielsen, P 2021, ' Double-Headed Nucleotides with Increased Base-Pairing Affinity and Specificity ', European Journal of Organic Chemistry, vol. 2021, no. 48, pp. 6717-6724 . https://doi.org/10.1002/ejoc.202101209
Double-headed nucleotides, i. e., nucleotides that hold two nucleobases each, have been shown to be double-functional in DNA duplexes by forming two sets of Watson−Crick base pairs, and thus mimicking dinucleotides. Herein, we present three new dou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d107f4fe7bcd69fcef90173da69611
https://portal.findresearcher.sdu.dk/da/publications/0d824ac6-eb7e-40e9-b922-242af6282025
https://portal.findresearcher.sdu.dk/da/publications/0d824ac6-eb7e-40e9-b922-242af6282025
Autor:
Chiranjeevi Bodda, Søren B. Jensen, Carsten Scavenius, Anne Troldborg, Christine Doucet, Cheng long Sun, Ramya Nandakumar, Anders Laustsen, Thaneas Prabakaran, Zong liang Gao, Samuel J. Windross, Harald Stenmark, Zheng Guo, Line S. Reinert, Sonia Assil, Rune Hartmann, Søren R. Paludan, Jinrong Huang, Martin K. Thomsen, Yan Zhang, Ryo Narita, Jan J. Enghild, Bao cun Zhang, Zhijian J. Chen, Raphaela Goldbach-Mansky, Takeshi Noda, David Olagnier, Rasmus O. Bak, Cong gang Zhang, Martin F. Berthelsen, Yujia Cai
Publikováno v:
Nature immunology
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occ
Autor:
Frank Riemer, Mary A. McLean, Ferdia A. Gallagher, Christoffer Laustsen, Rasmus Stilling Tougaard, Esben Søvsø Szocska Hansen, Nikolaj Bøgh, Joshua D. Kaggie, James T. Grist, Martin J. Graves
Publikováno v:
Kidney International
Grist, J T, Riemer, F, Hansen, E, Tougaard, R S, McLean, M A, Kaggie, J, Bøgh, N, Graves, M J, Gallagher, F A & Laustsen, C 2020, ' Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study ', Kidney International, vol. 98, no. 5, pp. 1174-1178 . https://doi.org/10.1016/j.kint.2020.04.056
Grist, J T, Riemer, F, Hansen, E, Tougaard, R S, McLean, M A, Kaggie, J, Bøgh, N, Graves, M J, Gallagher, F A & Laustsen, C 2020, ' Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study ', Kidney International, vol. 98, no. 5, pp. 1174-1178 . https://doi.org/10.1016/j.kint.2020.04.056
Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals
Autor:
Haiyun Qi, Per Mose Nielsen, Christian Østergaard Mariager, Christoffer Laustsen, James T. Grist
Publikováno v:
Grist, J T, Mariager, C Ø, Qi, H, Nielsen, P M & Laustsen, C 2020, ' Detection of acute kidney injury with hyperpolarized [ 13 C, 15 N]Urea and multiexponential relaxation modeling ', Magnetic Resonance in Medicine, vol. 84, no. 2, pp. 943-949 . https://doi.org/10.1002/mrm.28134
PURPOSE: To assess the utility of Laplacian fitting to describe the differences in hyperpolarized [13C, 15N]urea T2 relaxation in ischemic and healthy rodent kidneys.METHODS: Six rats with unilateral renal ischemia were investigated. [13C, 15N]urea T
Autor:
Andreas Hougaard Laustsen, Kalogeropoulos K, Jonas A. Jürgensen, Maudlin I, Macleod Ojs, Martos-Esteban A, Mark Carrington
African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane is covere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1bc3375faa011876ae739665ca2484b
https://doi.org/10.1101/2021.11.01.466813
https://doi.org/10.1101/2021.11.01.466813