Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Margery A. Connelly"'
Autor:
Keiji Tanigaki, Wan Ru Lee, Philip W. Shaul, Robert D. Gerard, Ryan E. Temel, Etienne Morel, Janet K. Sawyer, Manya Warrier, J. Mark Brown, Ivan S. Yuhanna, Margery A. Connelly, Chieko Mineo, Sajesh Parathath, Véronique Carrière, Sonika Saddar
Publikováno v:
Circulation Research. 112:140-151
Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1771:818-829
Expression of the scavenger receptor class B, type I (SR-BI) receptor facilitates high density lipoprotein cholesterol transport and correlates with protection against atherosclerosis. Studies have shown that SR-BI self-associates, but many of the te
Autor:
David L. Williams, Margarita de la Llera Moya, George H. Rothblat, Michael C. Phillips, Margery A. Connelly, Yolanda F. Darlington, Denise Drazul-Schrader, Saj Parathath
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1386-1395 (2007)
Scavenger receptor class B type I (SR-BI) facilitates the uptake of HDL cholesteryl esters (CEs) in a two-step process involving binding of HDL to its extracellular domain and transfer of HDL core CEs to a metabolically active membrane pool, where th
Autor:
David L. Williams, Patricia G. Yancey, Bela F. Asztalos, Nicolas Stettler, George H. Rothblat, David A. Piccoli, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 9, Pp 1724-1732 (2004)
Alagille syndrome is associated with bile duct paucity resulting in liver disease. Patients can be divided into mildly and severely icteric groups, with both groups having altered lipoproteins. The incidence of ischemic heart disease is rare in sever
Autor:
David L. Williams, Margery A. Connelly
Publikováno v:
Trends in Endocrinology & Metabolism. 14:467-472
Scavenger receptor class B, type I (SR-BI) is a receptor for high-density lipoprotein (HDL) that mediates cellular uptake of HDL cholesteryl ester (HDL CE) and is the major route for cholesterol delivery to the steroidogenic pathway. SR-BI is localiz
Autor:
Libo Wang, Margery A. Connelly, Anne G. Ostermeyer, David L. Williams, Deborah A. Brown, Hsu-hsin Chen
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 4, Pp 807-815 (2003)
Free cholesterol (FC) has been reported to efflux from cells through caveolae, which are 50–100 nm plasma membrane pits. The 22 kDa protein caveolin-1 is concentrated in caveolae and is required for their formation. The HDL scavenger receptor BI (S
Autor:
Yves L. Marcel, Douglas M Lublin, Vivian Franklin, Margery A. Connelly, Philippe G. Frank, Michael P. Lisanti, David L. Williams
Publikováno v:
Biochemistry. 41:11931-11940
Caveolae are 50-100 nm plasma membrane invaginations, which function in cell signaling, in transcytosis, and in regulating cellular cholesterol homeostasis. These subcompartments of the plasma membrane are characterized by the presence of caveolin pr
Autor:
Margery A. Connelly, George H. Rothblat, Seth M. Klein, Drazul D, Stoudt G, de la Llera-Moya M, Pascale Monzo, Fournier N, David L. Williams, P. G. Yancey
Publikováno v:
Biochemistry. 40:5249-5259
Scavenger receptor BI (SR-BI) mediates the selective uptake of high-density lipoprotein (HDL) cholesteryl ester (CE), a process by which HDL CE is taken into the cell without degradation of the HDL particle. In addition, SR-BI stimulates the bi-direc
Publikováno v:
Endocrine Research. 26:639-651
Adrenal cells obtain cholesterol for steroid production via the selective uptake of cholesteryl ester (CE) from HDL particles, a process in which CE is transferred to the plasma membrane without degradation of the HDL particle. Although this process
Autor:
Margery A. Connelly, David L. Williams, Stoudt G, George H. Rothblat, Christian Ae, de la Llera-Moya M, Haynes Mp, Ginny Kellner-Weibel
Publikováno v:
Biochemistry. 39:221-229
Previous studies have shown that scavenger receptor BI (SR-BI) stimulates the bidirectional flux of free cholesterol (FC) between HDL and SR-BI-expressing cells. A major component of the enhanced FC flux appears to occur independently of HDL binding