Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joan J. Guinovart"'
Autor:
Natasha T. Snider, Jelena Mann, Alexandre Louvet, Veronica Massey, Rajanikanth Vadigepalli, Pau Sancho-Bru, José Altamirano, Sheng Cao, Vijay H. Shah, Joan J. Guinovart, Juan Caballería, Càndid Villanueva, Zhaoli Sun, Aline Mello, Oriol Morales-Ibanez, Dalia Morales-Arraez, Carlos Prieto Martinez, Anna Adrover, Gemma Odena, Silvia Affò, Montserrat Moreno, Edilmar Alvarado-Tapias, Laurent Dubuquoy, Ramon Bataller, Andrew M. Cameron, Austin Parrish, Mar García-Rocha, Cristina Millán, P. Mathurin, Timothy R. Morgan, Josepmaria Argemi
Publikováno v:
GASTROENTEROLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Gastroenterology, vol 160, iss 5
Gastroenterology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Gastroenterology, vol 160, iss 5
Gastroenterology
Background & Aims We recently showed that alcoholic hepatitis (AH) is characterized by dedifferentiation of hepatocytes and loss of mature functions. Glucose metabolism is tightly regulated in healthy hepatocytes. We hypothesize that AH may lead to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5102083cd860ba8eef7989f1bf643e1d
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4964
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4964
Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins
Publikováno v:
FEBS Letters. 587:291-296
Tungstate treatment ameliorates experimental diabetes by increasing liver glycogen deposition through an as yet unidentified mechanism. The signalling mechanism of tungstate was studied in CHOIR cells and primary cultured hepatocytes. This compound e
Publikováno v:
Diabetologia. 54:2639-2648
Glycogen deposition is impaired in diabetes, thus contributing to the development of hyperglycaemia. Several glucose-lowering strategies have attempted to increase liver glycogen deposition by modulating targets, which eventually trigger the activati
Publikováno v:
Journal of Biological Chemistry. 284:6370-6378
Eukaryotic glycogen synthase activity is regulated by reversible phosphorylation at multiple sites. Of the two GS isoforms found in mammals, the muscle enzyme (muscle glycogen synthase) has received more attention and the relative importance of every
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G479-G484
Sodium tungstate reduces glycemia and reverts the diabetic phenotype in several induced and genetic animal models of diabetes. Oral administration of this compound has recently emerged as an effective treatment for diabetes. Here we examined the effe
Autor:
Ilona I. Concha, Alejandro J. Yáñez, Joan J. Guinovart, Juan C. Slebe, Manuel Grez, Doris E. Sáez, Mar García-Rocha, Cristian A. Droppelmann, Joel L. Asenjo
Publikováno v:
The Biochemical journal. 472(2)
Understanding how glucose metabolism is finely regulated at molecular and cellular levels in the liver is critical for knowing its relationship to related pathologies, such as diabetes. In order to gain insight into the regulation of glucose metaboli
Autor:
Delia Zafra, Joan J. Guinovart, Ciro Mercurio, Rosario Perona, Albert Barberà, Isabel Sánchez-Pérez, Jorge Domínguez, Martine Caron, Mª Carmen Muñoz, Susanna Baqué, Ramon Gomis
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Sodium tungstate is a powerful antidiabetic agent when administered orally. In primary cultured hepatocytes, tungstate showed insulin-like actions, which led to an increase in glycogen synthesis and accumulation. However, this compound did not signif
Autor:
Mariano Domingo, N. Prats, Ramon Gomis, Roger R. Gomis, Albert Barberà, Joan E. Rodríguez-Gil, Joan J. Guinovart
Publikováno v:
Diabetologia. 44:507-513
Aims/hypothesis. Recent studies have shown the anti diabetic effects of oral sodium tungstate treatment in several animal models of diabetes based on short-term experiments. In this study, we examined the effectiveness of long-term tungstate treatmen
The Role of the Regulatory Protein of Glucokinase in the Glucose Sensory Mechanism of the Hepatocyte
Publikováno v:
Journal of Biological Chemistry. 275:10597-10603
Glucokinase has a very high flux control coefficient (greater than unity) on glycogen synthesis from glucose in hepatocytes (Agius et al., J. Biol. Chem. 271, 30479-30486, 1996). Hepatic glucokinase is inhibited by a 68-kDa glucokinase regulatory pro
Autor:
Khiet Y. Trinh, Joan Seoane, Alex J. Lange, Joan J. Guinovart, Robert M. O'Doherty, Christopher B. Newgard, Anna M. Gómez-Foix
Publikováno v:
Journal of Biological Chemistry. 272:26972-26977
Glucose-6-phosphatase (G6Pase) catalyzes the hydrolysis of glucose 6-phosphate (Glu-6-P) to free glucose and, as the last step in gluconeogenesis and glycogenolysis in liver, is thought to play an important role in glucose homeostasis. G6Pase activit