Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yan Lou"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 1, Pp 10-20 (2021)
Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely reported to ameliorate diabetes-associated disease. The current study is designed to explore the mechanism of hyperoside in diabetic nephropathy. In the present st
Autor:
Lushan Yu, Jinxiu Lei, Lu Chen, Sheng Ye, Suhang Guo, Su Zeng, Yan Lou, Ying Zhou, Junqing Liu, Chaonan Ye
Publikováno v:
Molecular Pharmacology. 97:259-266
Colorectal cancer (CRC) is known to be the third most common cancer disease and the fourth-leading cause of cancer-related deaths worldwide. Bile acid, especially deoxycholic acid and lithocholic acid, were revealed to play an important role during c
Publikováno v:
Current Pharmaceutical Analysis. 13:232-240
Autor:
Rama K. Kondru, Sung-Sau So, Andreas Kuglstatter, Yan Lou, Francisco Javier Lopez-Tapia, Christine E. Brotherton-Pleiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(9)
A seven-membered cyclic chiral analog of potent lead BTK inhibitor 1 was envisioned by structure-based design to lock the molecule into its bioactive conformation. For the elaboration of the seven-membered ring, compound 1 pyridone 6-position was sub
Autor:
Huidi Jiang, Yan Lou, Lushan Yu, Haihong Hu, Su Zeng, Jian-Zhong Chen, Lanying Pan, Xiangjun Wang
Publikováno v:
Molecules
Volume 20
Issue 2
Pages 2931-2948
Molecules, Vol 20, Iss 2, Pp 2931-2948 (2015)
Volume 20
Issue 2
Pages 2931-2948
Molecules, Vol 20, Iss 2, Pp 2931-2948 (2015)
Stellera chamaejasme L. (Thymelaeaceae) is widely distributed in Mongolia, Tibet and the northern parts of China. Its roots are commonly used as "Langdu", which is embodied in the Pharmacopoeia of the P.R. China (2010) as a toxic Traditional Chinese
Autor:
Yan Lou, Sharadha Subramanian, Yingyun Wang, Lifeng Wan, John Tellew, Laura Tandeske, Benjamin R. Taft, Kalyani Gampa, Jacob R. Haling, Gisele Nishiguchi, Lina Setti, Alice Rico, Sylvia Ma, Payman Amiri, Mallika Singh, Huw Tanner, Brent A. Appleton, Robert J. Aversa, Sepideh Vaziri, Shenlin Huang, Johanna M. Jansen, Anne Van Abbema, Jing Yuan, Vesselina G. Cooke, Hanne Merritt, Aaron Smith, Wenlin Shao, Valery Polyakov, Fei Feng, Savithri Ramurthy, Matthew Burger, Mulugeta Mamo, Lesley A. Mathews Griner, Vijay Sethuraman, Victoriano Tamez, Michael Patrick Dillon, Emma Lees, Ina Dix, Paul A. Barsanti, Richard Zang, Darrin Stuart, Mohammad Hekmat-Nejad
Publikováno v:
Journal of medicinal chemistry. 60(12)
RAS oncogenes have been implicated in30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cells. To d
Autor:
Judy M. Suh, Sandra Frauchiger, Michael Soth, Xiaochun Han, Ronald J. Hill, Buelent Kocer, Taygerly Joshua Paul Gergely, Jaehyeon Park, Hong Jun-Bae, Andreas Kuglstatter, Rama K. Kondru, Tobias Gabriel, Renee Litman, Yan Lou, Zachary Kevin Sweeney, Mcintosh Joel, Nolan James Dewdney, Dana Davis, David Michael Goldstein, Timothy D. Owens, Hasim Zecic, Keshab Sarma
Publikováno v:
Journal of Medicinal Chemistry. 58:512-516
Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol group and a fluorine substitution, each o
Publikováno v:
Planta Medica. 80:493-497
Chamaechromone is a major component in the dried roots of Stellera chamaejasme with antihepatitis B virus and insecticidal activity. In this study, metabolic profiles of chamaechromone were investigated in human liver microsomes. One monohydroxide an
Autor:
Peter Michael Wovkulich, Anjali Nangia, Jenny Tan, Paola Di Lello, Shelly Gleason, Ramona Hilgenkamp, Tian Yang, Jennifer Fretland, Yongying Jiang, Lucja Orzechowski, Timothy D. Owens, Buelent Kocer, Francisco J. Lopez, Fang‐Jie Zhang, Steve Gabriel, Roland J. Billedeau, David Michael Goldstein, Bo Wen, Yan Lou, Chris Brotherton, David C. Fry, Lucy Chen, Xiaochun Han
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(3)
Reactive metabolites have been putatively linked to many adverse drug reactions including idiosyncratic toxicities for a number of drugs with black box warnings or withdrawn from the market. Therefore, it is desirable to minimize the risk of reactive
Publikováno v:
Journal of Medicinal Chemistry. 55:4539-4550