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Autor:
Şeyma Osmanlıoğlu, Hakan Parlakpinar, Onural Ozhan, Azibe Yildiz, Merve Goksin Karaaslan, Nigar Vardi
Publikováno v:
Biotechnic & Histochemistry. 97:261-268
Valproate (VPA) induced changes in ovarian morphology are observed in humans with epilepsy and in non-epileptic animals. The effects of lamotrigine (LTG) on female reproduction is not well known. We investigated whether LTG might be a safer drug for
Autor:
Roshanak Hariri, Mohammad Mahdavi, Mina Saeedi, Zahra Najafi, Syed Nasir Abbas Bukhari, Fahimeh Vafadarnejad, Aida Iraji, Arezoo Rastegari, Maliheh Safavi, Tahmineh Akbarzadeh, Omidreza Firuzi, Najmeh Edraki
Publikováno v:
Molecular Diversity. 26:409-428
Alzheimer’s disease (AD) is now ranked as the third leading cause of death after heart disease and cancer. There is no definite cure for AD due to the multi-factorial nature of the disease, hence, multi-target-directed ligands (MTDLs) have attracte
Autor:
Anna Boguszewska-Czubara, Maria Zykubek, Łukasz Kurach, Agnieszka Michalak, Olga Wronikowska, Barbara Budzyńska
Publikováno v:
Psychopharmacology
Rationale Mephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of action, as well as toxic and psychoactive effects, has been widely studied, the role of different factor
Autor:
Susan M. Webb, Alicia Santos, Anna Aulinas, Mary E. McCaul, Richard S. Lee, Gary S. Wand, Eugenia Resmini, Jenny L. Carey, Peter P. Zandi
Publikováno v:
J Clin Endocrinol Metab
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
ContextChronic exposure to glucocorticoids (GCs) or stress increases the risk of medical disorders, including cardiovascular and neuropsychiatric disorders. GCs contribute to accelerated aging; however, while the link between chronic GC exposure and
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefi
Autor:
Mohammad Abdollahi, Maryam Baeeri, Mahban Rahimifard, Hamed Haghi-Aminjan, Shermineh Moini-Nodeh, Mahshid Hodjat
Publikováno v:
Drug Research. 71:438-447
The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In t
Publikováno v:
Drug and Chemical Toxicology. 45:2185-2192
Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that potent, centra
Publikováno v:
Seminars in Immunopathology
Bile acids and their signaling pathways are increasingly recognized as potential therapeutic targets for cholestatic and metabolic liver diseases. This review summarizes new insights in bile acid physiology, focusing on regulatory roles of bile acids
Autor:
Władysława A. Daniel, Paulina Surówka, Patrycja Kleczkowska, Magdalena Zadrożny-Bujalska, Joanna Jastrzębska, Renata Pieniążek, Agata Suder, Renata Pukło, Małgorzata Filip, Małgorzata Frankowska
Publikováno v:
Pharmacological Reports
Background Opioid use disorders are serious contributors to the harms associated with the drug use. Unfortunately, therapeutic interventions for opioid addicts after detoxification have been limited and not sufficiently effective. Recently, several s
Autor:
Matthew G. Korber, Srihari R. Tella, Ellen A. Walker, Li Fang, Christina R. Chambers, Cassandra Prioleau
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:1-11
Compounds with novel or fentanyl-like structures continue to appear on the illicit drug market and have been responsible for fatalities, yet there are limited preclinical pharmacological data available to evaluate the risk of these compounds to publi