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Publikováno v:
Pflugers Archiv
Earlier evidence from studies of rat hypertension models undermines the widespread view that the rate of renal medullary blood flow (MBF) is critical in control of arterial pressure (MAP). Here, we examined the role of MBF in rats that were normotens
Publikováno v:
Clinical and Experimental Hypertension. 42:118-125
Background and Objective: Evaluate the activity of dopamine-β-hydroxylase (DβH) as well as the effect of the DβH inhibitor nepicastat upon enzyme activity and levels of dopamine (DA) and norepinephrine (NE) in the rat left ventricle, kidney, and a
Publikováno v:
General physiology and biophysics. 38:165-173
Ivabradine, a selective inhibitor of the sinoatrial pacemaker, is used in clinical practice to reduce heart rate. However, its potential effect on the neuroendocrine stress response has not been investigated. Therefore, we determined the effect of ad
Autor:
Cynthia Gershome, BaRun Kim, Damon Poburko, Nickolas Saraev, Jagdeep Singh Walia, Somayeh Mojarad Kalkhoran, Sarah Heather Jane Chow
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H89-H105
ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca2+ influx through specific voltage-ga
Autor:
Charlotte Mehlin Sorensen, Jens Chr. Brings Jacobsen, Rasmus Bo Sørensen, Preben Graae Sørensen, Bjørn Olav Hald
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 471:271-283
Resistance vessels regulate blood flow by continuously adjusting activity of the wall smooth muscle cells. These cells integrate a variety of stimuli from blood, endothelium, autonomic nerves, and surrounding tissues. Each stimulus elicits an intrace
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES. 48(3)
Anti-inflammatory products may represent the future for depressive disorder therapies. Curcumin (CUR) is a polyphenol and an active component of the turmeric plant Curcuma longa. The aim of this study was to investigate the impact of CUR, as a natura
Publikováno v:
Neuroscience Bulletin
The present study was designed to investigate the mechanisms by which P2X7 receptors (P2X7Rs) mediate the activation of vasopressinergic neurons thereby increasing sympathetic hyperactivity in the paraventricular nucleus (PVN) of the hypothalamus of
Publikováno v:
Pflugers Archiv : European journal of physiology. 472(3)
We investigated the direct effects of prolonged exposure to advanced glycation end-products (AGEs) on noradrenaline-induced contraction of rat carotid artery smooth muscle. Noradrenaline-induced contraction of endothelium-denuded carotid artery rings
Autor:
Daisuke Chino, Chihiro Suzuki, Shunsuke Shiina, Ayaka Kanemura, Keisuke Obara, Fumiko Yamaki, Yoshio Tanaka
Publikováno v:
Journal of Smooth Muscle Research
Object We identified the β-adrenoceptor (β-AR) subtypes responsible for the relaxant responses to adrenaline (AD) and noradrenaline (NA) in the rat thoracic aorta and examined the role of cAMP which is involved in these relaxant responses. Methods
Publikováno v:
Stress. 21:274-278
Nitrous oxide (N(2)O) is a gaseous drug with abuse potential. Despite its common clinical use, little is known about whether N(2)O administration activates the HPA axis and/or the sympathetic adrenomedullary system. The goal of this study was to dete