Zobrazeno 1 - 10
of 408
pro vyhledávání: '"Hua Zhang"'
Autor:
Hongda Lin, Mengling Liu, Sheng Ma, Yan Zhan, Zhe Zhang, Yuandong Zheng, Guangze Li, Xingxing Diao, Dafang Zhong, Liyan Miao, Zhendong Chen, Hua Zhang
Publikováno v:
Drug Metabolism and Disposition. 50:798-808
HR011303, a promising selective URAT1 inhibitor, is currently being studied in a phase Ⅲ clinical trial in China for the treatment of hyperuricemia and gout. In the current study, the pharmacokinetics, mass balance, and metabolism of HR011303 were
Publikováno v:
Journal of the Energy Institute. 99:198-208
Impurities are inevitable in crude glycerol, a by-product of biodiesel, which has a great influence on aqueous phase reforming (APR). This work investigates three impurities (CH3OH, CH3COOH, and KOH) in the aqueous phase reforming of glycerol (GAPR)
Autor:
Hongyun Lu, Qinghua Zhou, Qiping Shi, Caixian Yang, Vishwa Deep Dixit, Xiaoyong Yang, Rachel J. Perry, Zhinan Yin, Dehai Li, Shengqi He, Yunfan Yang, Gerald I. Shulman, Cunchuan Wang, Hengwen Yang, Yong Liu, Hua Zhang, Hao Xu, Guangchao Cao, Ligong Lu, Zonghua Liu, Mingyue Zhang, Jing Zhu, Xiaoli Wu, Baocheng Wang, Libing Zhou, Hao Cheng, Qiong Wen, Richard A. Flavell, Guangqiang Li, Qian Wang, Yong Chen, Leqing Zhu, Yongjie Xin, Zhenyu Ju, Olga Spadaro
Publikováno v:
Nature. 600:314-318
Thermogenesis in brown and beige adipose tissue has important roles in maintaining body temperature and countering the development of metabolic disorders such as obesity and type 2 diabetes1,2. Although much is known about commitment and activation o
Autor:
Xia-Qing Wu, Ying-Yong Zhao, Hua Miao, Xiao-Yong Yu, Yan-Long Zhao, Dan-Qian Chen, Wei Su, Yuan Zhang, Shougang Zhuang, Yan Guo, You-Quan Shang, Jia-Rong Mao, Jin Zhao, Nosratola D. Vaziri, Ming Gao, Huan-Qiao Zhang, Gang Cao, Yan-Ni Wang, Li Zhang, Shi-Xing Ma, Jin-Hua Zhang, Lin Chen
Publikováno v:
British Journal of Pharmacology. 179:103-124
BACKGROUND AND PURPOSE In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the molecular pathways targeted by me
Autor:
Wen-Ting Wu, Song Xinqi, Zhenzhong Zang, Dong Huanhuan, Hua Zhang, Yong-Mei Guan, Wei-Feng Zhu
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Kudzu is a traditional medicinal dietary supplement, and recent research has shown its significant benefits in the prevention/treatment of type 2 diabetes mellitus (T2DM). Starch is one of the main substances in Kudzu that contribute decisively to th
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 1142-1153 (2020)
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 1142-1153 (2020)
Dysregulated expression of microRNAs (miRNAs or miRs) has been implicated in the pathophysiology of type 2 diabetes mellitus (T2DM). However, their underlying role in the complication of detrusor fibrosis remains poorly understood. Therefore, this st
Publikováno v:
ESC Heart Failure, Vol 8, Iss 4, Pp 2637-2646 (2021)
ESC Heart Failure
ESC Heart Failure
Hyperglycaemia is a major aetiological factor in the development of diabetic cardiomyopathy. Excessive hyperglycaemia increases the levels of reactive carbonyl species (RCS), reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the he
Autor:
Peifeng Li, Zhixia Zhou, Zhe Zhang, Sujie Zhu, Hongzhao Qi, Jie Yu, Caixia Hou, Chuanxiao Wang, Feifei Yang, Zhenqing Sun, Lirong Wang, Yunjie Hu, Kun Wang, Peipei Shan, Hua Zhang
Publikováno v:
Cancer Research. 81:4027-4040
Triple-negative breast cancer (TNBC) exhibits a high mortality rate and is the most aggressive subtype of breast cancer. As previous studies have shown that histone deacetylases (HDAC) may represent molecular targets for TNBC treatment, we screened a
Autor:
Spencer K. Tumbale, R. Holland Cheng, Elizabeth S. Ingham, Wei-Lun Tang, Sarah M. Tam, Bo Wu, Alexander D. Borowsky, Katherine W. Ferrara, Mo Baikoghli, Marina Nura Raie, Brett Z. Fite, Josquin Foiret, Azadeh Kheirolomoom, Lisa M. Mahakian, Hua Zhang, Kenneth Lau
Publikováno v:
J Control Release
Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and systemic immune activation. In
Autor:
Kaicen Wang, Hua Zhang, Xiaoling Su, Yingfeng Lu, Longxian Lv, Huiyong Jiang, Ren Yan, Lanjuan Li, Qiangqiang Wang, Xiaoxiao Chen, Lifeng Chen, Yi-Ling Du
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 1, Pp 247-261 (2022)
Microbial Biotechnology
Microbial Biotechnology
Summary Millions of people die from liver diseases annually, and liver failure is one of the three major outcomes of liver disease. The gut microbiota plays a crucial role in liver diseases. This study aimed to explore the effects of Lactobacillus ca