Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tetsuya Hosooka"'
Autor:
Makoto Imamori, Shingo Kajimura, Yuko Nabatame, Chikako Aoki, Yuko Okamatsu-Ogura, Wataru Ogawa, Yoshikazu Tamori, Tetsuya Hosooka, Yusei Hosokawa, Takeshi Yoneshiro, Masayuki Saito
Publikováno v:
Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 7, Pp 1144-1151 (2021)
Journal of Diabetes Investigation, Vol 12, Iss 7, Pp 1144-1151 (2021)
Aims/Introduction Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood. We have now investigated the role of
Autor:
Masakazu Shinohara, Makoto Imamori, Wataru Ogawa, Tetsuya Hosooka, Yusei Hosokawa, Kei Yoshino, Chikako Aoki
Publikováno v:
Biochemical and Biophysical Research Communications. 557:62-68
Clinical and animal studies have suggested a possible beneficial effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH). Although SGLT2 inhibitors have bee
Autor:
Kei Yoshino, Yuko Nabatame, Masakazu Shinohara, Kazuhiro Nomura, Yoshitake Hayashi, Kaku Matsugi, Wataru Ogawa, Kanji Yamaguchi, Hiroshi Sakaue, Tsutomu Sasaki, Sho Matsui, Tadahiro Kitamura, Yusei Hosokawa, Takehiko Yokomizo, Yoshikazu Tamori, Jun Nakae, Domenico Accili, Tetsuya Hosooka, Masato Kasuga, Chikako Aoki, Yoko Senga, Susumu Seino, Masashi Kuroda, Yoshito Itoh
Publikováno v:
Proceedings of the National Academy of Sciences. 117:11674-11684
Although adipocytes are major targets of insulin, the influence of impaired insulin action in adipocytes on metabolic homeostasis remains unclear. We here show that adipocyte-specific PDK1 (3'-phosphoinositide-dependent kinase 1)-deficient (A-PDK1KO)
Autor:
Ken-ichi Hirata, Yushi Hirota, Wataru Ogawa, Akihiko Kondo, Yoshiharu Shimomura, Masayuki Saito, Seiichi Kitahama, Kengo Sasaki, Masakazu Shinohara, Tatsunori Osone, Shingo Kajimura, Takeshi Yoneshiro, Takuji Yamada, Tetsuya Hosooka, Yoshihiro Saito, Yasuyuki Kitaura, Takuo Emoto, Yuko Okamatsu-Ogura, Takeshi Inagaki, Tomohiro Suzuki, Genki Ozawa, Daisuke Sasaki, Naofumi Yoshida, Tomoya Yamashita
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103342-(2021)
iScience, Vol 24, Iss 11, Pp 103342-(2021)
Summary The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids
Publikováno v:
Biochemical and biophysical research communications. 505(1)
Thiazolidinediones exert their antidiabetic effect in part by ameliorating chronic inflammation in adipose tissue. However, the precise mechanism of this anti-inflammatory action has remained unclear. We here investigated the effects of the TZD piogl
Autor:
Wataru Ogawa, Tetsuya Hosooka
Publikováno v:
Diabetes. 67
Although adipocytes are major targets of insulin, the influence of impaired insulin action in adipocytes on metabolic homeostasis has been unclear. To provide insight into the role of insulin action in adipocytes, we generated mice that lack 3'-phosp
Publikováno v:
Journal of Diabetes Investigation
Insulin resistance, a key feature of type 2 diabetes, contributes to a variety of pathological conditions including dyslipidemia, hypertension, atherosclerosis, cognitive disorders and cancer. Obesity, defined as increased lipid deposition in adipose
Autor:
Tetsuya Hosooka, Wataru Ogawa
Publikováno v:
Diabetology International. 3:65-67
Resveratrol, a natural polyphenol first identified and named by a Japanese chemist in 1940 [1], is present in many plant products, including grape skin. It has been the focus of much attention recently because it provides a variety of potential healt
Autor:
Hiroaki Etoh, Ayumi Kanno, Shinobu Shimizu, Hiroaki Takahashi, Yusuke Mieda, Hiroyuki Inoue, Yoshiaki Kido, Susumu Seino, Maki Koyanagi-Kimura, Alberto Bartolomé, Shun-ichiro Asahara, Kyoko Teruyama, Megumi Fuchita, Naoko Hashimoto, Tetsuya Hosooka, Tomokazu Matsuda
Publikováno v:
Journal of molecular endocrinology. 49(2)
The development of type 2 diabetes is accompanied by a progressive decline in β-cell mass and function. Vildagliptin, a dipeptidyl peptidase 4 inhibitor, is representative of a new class of antidiabetic agents that act through increasing the express
Autor:
Mitchell A. Lazar, Yuji Yamanashi, Wataru Ogawa, Hiroshi Inoue, Ko Kotani, Masato Kasuga, Hiroshi Sakaue, Tomoharu Yasuda, Kazutoshi Tobimatsu, Takehiro Nakamura, Tetsuya Hosooka, Tetsuya Noguchi, Mashito Sakai, Yasushi Matsuki, Ryuji Hiramatsu, Kazuo Takazawa
Publikováno v:
Nature medicine. 14(2)
Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such as Gab1, c-Cbl, SH2-B and APS, are also of physiological relevance. Although the protein downstream o