Zobrazeno 1 - 10
of 26
pro vyhledávání: '"S. Jin"'
Autor:
Natalia de Albuquerque Rocha, Craig R. Malloy, Connor Hughes, Eunsook S. Jin, Colby R. Ayers, Ian J. Neeland
Publikováno v:
Obesity (Silver Spring)
Objective The aim of this study was to determine the effects of empagliflozin on glycerol-derived hepatic gluconeogenesis in adults with obesity without type 2 diabetes mellitus (T2DM) using oral carbon 13 (13 C)-labeled glycerol. Methods A randomize
Autor:
Jun Chen, Sha S. Jin, Courtney D. DiNardo, Duncan H. Mak, Jing Wang, Paul Koller, Deepak Sampath, Vivian Ruvolo, Marina Konopleva, Steven Grant, Eugene Kim, Hagop M. Kantarjian, Elias Jabbour, Yang Zhao, Ce Shi, Mohamed Rahmani, Naval Daver, Monique Dail, Qi Zhang, Darren C. Phillips, Rodrigo Jacamo, Lina Han, Jared K. Burks, Antonio Cavazos, Joel D. Leverson, Michael Andreeff
Publikováno v:
Haematologica
The pathogenesis of acute myeloid leukemia (AML) involves serial acquisition of mutations controlling several cellular processes, requiring combination therapies affecting key downstream survival nodes in order to treat the disease effectively. The B
Autor:
Elizabeth J. Parks, Craig R. Malloy, Eunsook S. Jin, Melanie Cree-Green, Kate M Bubar, Cecilia Diniz Behn
Publikováno v:
J Investig Med
Stable isotope tracers have been used to gain an understanding of integrative animal and human physiology. More commonly studied organ systems include hepatic glucose metabolism, lipolysis from adipose tissue, and whole body protein metabolism. Recen
Autor:
Yesenia Garcia-Reyes, Craig R. Malloy, Kristen J. Nadeau, Haseeb Rahat, Eunsook S. Jin, Anne-Marie Carreau, Melanie Cree-Green
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Hepatic energy metabolism is a key element in many metabolic diseases. Hepatic anaplerosis provides carbons for gluconeogenesis (GNG) and triglyceride (TG) synthesis. We aimed to optimize a protocol that measures hepatic anaplerotic contribution for
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
Journal of Lipid Research, Vol 59, Iss 9, Pp 1685-1694 (2018)
It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride ac
Autor:
Jieli Wei, Lihuai Qin, Hyerin Yim, Kabir, Jing Liu, Jian Jin, Margaret S Jin, Jianping Hu, Xian Chen, Li Wang, Ling Xie
Publikováno v:
J Med Chem
Previously, we reported a first-in-class von Hippel-Lindau (VHL)-recruiting mitogen-activated protein kinase kinases 1 and 2 (MEK1/2) degrader, MS432. To date, only two MEK1/2 degrader papers have been published and very limited structure-activity re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e522fd68f78e14f4316e82b62fec0b46
https://europepmc.org/articles/PMC7770057/
https://europepmc.org/articles/PMC7770057/
Publikováno v:
Journal of medicinal chemistry. 62(23)
MEK1 and MEK2 (also known as MAP2K1 and MAP2K2) are the "gatekeepers" of the ERK signaling output with redundant roles in controlling ERK activity. Numerous inhibitors targeting MEK1/2 have been developed including three FDA-approved drugs. However,
Publikováno v:
Neoplasma. 67(6)
Puerarin has recently been demonstrated to play anti-cancer roles in a series of human cancers, including non-small cell lung cancer (NSCLC), possibly through regulation of cancer-related microRNAs (miRNAs). The purpose of the present study was to fu
Autor:
Aaron P. Schultz, David S. Jin, Teresa Gomez-Isla, Matthew P. Frosch, Reisa A. Sperling, Nicolas V Andrea, John A. Becker, Christopher C. M. Lee, Keith A. Johnson, Marta Marquié, Heidi I.L. Jacobs
Publikováno v:
Journal of Alzheimer's Disease, 62(4), 1691-1702. IOS Press
Background: On target F-18-Flortaucipir (FTP) binding of Alzheimer's disease tau aggregates and off-target binding of melanocytes have been demonstrated with autoradiography. Objective: We aimed to investigate the hypothesis that if binding in choroi
Publikováno v:
Public Health. 148:30-36
Objectives To evaluate the effect of therapeutic lifestyle change with a non-pharmacological intervention method in older adults with dyslipidaemia. Study design Stratified randomized trial. Methods Participants with dyslipidaemia ( n = 214) aged ≥