Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer, Baker"'
Autor:
Louisa E, Jeffery, Omar S, Qureshi, David, Gardner, Tie Z, Hou, Zoe, Briggs, Blagoje, Soskic, Jennifer, Baker, Karim, Raza, David M, Sansom
Publikováno v:
PLoS ONE
The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice. However, l
A Transendocytosis model of CTLA-4 function predicts its suppressive behaviour on regulatory T cells
Autor:
Chun Jing Wang, Stephen P. Young, Jennifer Baker, Lucy S. K. Walker, Tie Zheng Hou, Omar S. Qureshi, David M. Sansom
Manipulation of the CD28/CTLA-4 pathway is at the heart of a number of immunomodulatory approaches used in both autoimmunity and cancer. Although it is clear that CTLA-4 is a critical regulator of T cell responses, the immunological contexts in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9146ec5db84e0304867f7b7b7dfdecee
https://europepmc.org/articles/PMC4522736/
https://europepmc.org/articles/PMC4522736/
Autor:
Louisa E Jeffery, Omar S Qureshi, David Gardner, Tie Z Hou, Zoe Briggs, Blagoje Soskic, Jennifer Baker, Karim Raza, David M Sansom
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131539 (2015)
The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice. However, l
Autor:
Clare E. Futter, Satdip Kaur, Tie Z. Hou, David M. Sansom, Louisa E. Jeffery, Graham Anderson, Kesley Attridge, Yong Zheng, Emily M. Schmidt, Kyoko Nakamura, Zoe Briggs, Claire N. Manzotti, Lucy S. K. Walker, Omar S. Qureshi, Jennifer Baker
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dbc36320f2d3f55af96da3372582f7
https://publications.aston.ac.uk/id/eprint/37153/1/ukmss_36978.pdf
https://publications.aston.ac.uk/id/eprint/37153/1/ukmss_36978.pdf
Autor:
Galvin, Jennifer Baker
Publikováno v:
All Graduate Theses and Dissertations
Cell-mediated immunity (CMI) in the lung has not been well characterized due to the lack of applicable tests. A major objective was to define pulmonary CMI serially in immunized and control lung lobes using the leukocyte procoagulant (LPCA) assay in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869706e943f0377fb21ef150b87fc71e