Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Masayuki Kanai"'
Publikováno v:
Oncogene. 25:5377-5390
Abnormal amplification of centrosomes, commonly found in human cancer, is the major cause of mitotic defects and chromosome instability in cancer cells. Like DNA, centrosomes duplicate once in each cell cycle, hence the defect in the mechanism that e
Autor:
Shuji Hanai, Masanao Miwa, Sayaka Ohashi, Fumiaki Uchiumi, Masayuki Kanai, Hideharu Maruta, Sei-ichi Tanuma
Publikováno v:
Biochemical and Biophysical Research Communications. 307:915-921
Posttranslational modification plays important roles in a range of cellular functions. Poly(ADP-ribosyl)ation influences DNA repair, transcription, centrosome duplication, and chromosome stability. Poly(ADP-ribose) attached to acceptor proteins shoul
Publikováno v:
Molecular and Cellular Biology. 23:2451-2462
The regulatory mechanism of centrosome function is crucial to the accurate transmission of chromosomes to the daughter cells in mitosis. Recent findings on the posttranslational modifications of many centrosomal proteins led us to speculate that thes
Autor:
Masayuki Kanai, Kenji Fukasawa
Publikováno v:
Mortalin Biology: Life, Stress and Death ISBN: 9789400730267
Numeral abnormality of centrosomes (presence of more than two centrosomes) leads to mitotic defects and high frequencies of chromosome segregation errors. Centrosome amplification occurs frequently in various types of human cancers, and is believed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aab2fa786efeda7c62bcce8686a1233
https://doi.org/10.1007/978-94-007-3027-4_15
https://doi.org/10.1007/978-94-007-3027-4_15
Publikováno v:
Oncogene. 27(40)
Abnormal amplification of centrosomes, which occurs frequently in cancers, leads to high frequencies of mitotic defect and chromosome segregation error, profoundly affecting the rate of tumor progression. Centrosome amplification results primarily fr
Publikováno v:
Poly(ADP-Ribosyl)ation ISBN: 9780387333717
The chemical structure of poly(ADP-ribose) suggests not only that its modification of acceptor proteins should modify the structure and function of the acceptor proteins, but also that the poly(ADP-ribose) molecule itself should possess an intrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeaf18a7373b6af387035f8c0daaaad4
https://doi.org/10.1007/0-387-36005-0_5
https://doi.org/10.1007/0-387-36005-0_5
Autor:
Christopher P. Mattison, Hideki Izumi, Kenji Fukasawa, Song-Hee Kim, Mark Winey, Masayuki Kanai, Zhiyong Ma
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 12(6)
Mortalin is a member of Hsp70 chaperoning protein family involved in various cellular functions. Through the search of the kinases that mortalin physically interact with, we identified Mps1 as such a kinase. Mps1 kinase has been implicated in the reg
Publikováno v:
Biochemical and biophysical research communications. 359(3)
The centrosome plays a vital role in maintaining chromosomal stability. Known as the microtubule organizing center, the centrosome is involved in the formation of spindle poles during mitosis, which ensures the distribution of the correct number of c
Publikováno v:
Molecular and cellular biology. 26(23)
Nucleophosmin (NPM)/B23 has been implicated in the regulation of centrosome duplication. NPM/B23 localizes between two centrioles in the unduplicated centrosome. Upon phosphorylation on Thr(199) by cyclin-dependent kinase 2 (CDK2)/cyclin E, the major
Autor:
Keiichi I. Nakayama, Manfred Schwab, Soichiro Saito, Kenji Fukasawa, Keiko Nakayama, Eiji Sugihara, Takayuki Nitta, Hideyuki Saya, Masayuki Kanai, Masanao Miwa, Hideo Toyoshima
Publikováno v:
Cancer research. 66(8)
The centrosome plays a fundamental role in cell division, cell polarity, and cell cycle progression. Centrosome duplication is mainly controlled by cyclin-dependent kinase 2 (CDK2)/cyclin E and cyclin A complexes, which are inhibited by the CDK inhib