Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leandro F. Vendruscolo"'
Autor:
Mehdi Farokhnia, Christopher T. Rentsch, Vicky Chuong, M. Adrienne McGinn, Sophie K. Elvig, Eliza A. Douglass, Luis A. Gonzalez, Jenna E. Sanfilippo, Renata C. N. Marchette, Brendan J. Tunstall, David A. Fiellin, George F. Koob, Amy C. Justice, Lorenzo Leggio, Leandro F. Vendruscolo
Publikováno v:
Mol Psychiatry
Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR) antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may represent a novel pharmacotherapy for alcohol use disorder (AUD). In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b30d20cea46f5800998006f39bd589
https://researchonline.lshtm.ac.uk/id/eprint/4667528/1/Farokhnia_etal_2022_Spironolactone-as-a-potential-new.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4667528/1/Farokhnia_etal_2022_Spironolactone-as-a-potential-new.pdf
Autor:
Stephanie A. Carmack, Janaina C. M. Vendruscolo, M. Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D. Bosse, Daniele Mercatelli, Federico M. Giorgi, Yu Fu, Anthony J. Hinrich, Francine M. Jodelka, Karen Ling, Robert O. Messing, Randall T. Peterson, Frank Rigo, Scott Edwards, Pietro P. Sanna, Marisela Morales, Michelle L. Hastings, George F. Koob, Leandro F. Vendruscolo
Publikováno v:
Molecular psychiatry. 27(5)
The global crisis of opioid overdose fatalities has led to an urgent search to discover the neurobiological mechanisms of opioid use disorder (OUD). A driving force for OUD is the dysphoric and emotionally painful state (hyperkatifeia) that is produc
Autor:
Brendan J. Tunstall, Adriana Gregory-Flores, George F. Koob, Olivier George, Joel E. Schlosburg, Giordano de Guglielmo, Leandro F. Vendruscolo, M. Adrienne McGinn, Hazel Hunt, Barbara J. Mason
Publikováno v:
Neuropharmacology
Alcohol use disorder (AUD) is associated with the dysregulation of brain stress and reward systems, including glucocorticoid receptors (GRs). The mixed glucocorticoid/progesterone receptor antagonist mifepristone and selective GR antagonist CORT11317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc96816bd8932829ce0f439c87e1cbd9
https://escholarship.org/uc/item/28w4t2f1
https://escholarship.org/uc/item/28w4t2f1
κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats
Autor:
Leandro F. Vendruscolo, Erika R. Carlson, Agnieszka Sulima, George F. Koob, Kenner C. Rice, Brendan J. Tunstall, Adriana Gregory-Flores, Shelley N. Jackson, Renata C. N. Marchette
Publikováno v:
Neurobiology of Stress
Neurobiology of Stress, Vol 14, Iss, Pp 100325-(2021)
Neurobiology of Stress, Vol 14, Iss, Pp 100325-(2021)
Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent r
Autor:
Eleanor B. Towers, George F. Koob, Leandro F. Vendruscolo, Brendan J. Tunstall, Mandy McCracken
Publikováno v:
Neuropharmacology
Opioid use disorder is a serious public health issue in the United States. Animal models of opioid dependence are fundamental for studying the etiology of addictive behaviors. We tested the hypothesis that extended access to heroin self-administratio
Autor:
Jianjing Cao, Janaina C. M. Vendruscolo, Rana Rais, Alexandra J. Gadiano, Leandro F. Vendruscolo, Brooke E. Schmeichel, Rachel D. Slack, Chelsea P. Ho, Gianluigi Tanda, Brendan J. Tunstall, Amy Hauck Newman, George F. Koob, Barbara S. Slusher
Publikováno v:
Neuropharmacology. 131:96-103
Methamphetamine (METH) is a highly addictive drug, but no pharmacological treatment is yet available for METH use disorders. Similar to METH, the wake-promoting drug (R)- modafinil (R-MOD) binds to the dopamine transporter (DAT). Unlike METH, R-MOD i
Autor:
Bin Gao, Christine Muench, Leandro F. Vendruscolo, Colin A. Hodgkinson, Hui Sun, Rebecca R. Fanelli, Andrew Holmes, Reza Momenan, Mingjiang Xu, Melanie L. Schwandt, Zhou Zhou, Jill L. Sorcher, Kelsey L. Mauro, David T. George, Monte J. Phillips, George F. Koob, Falk W. Lohoff, Ilenna Simone Jones, Allison D. Rosen, Zachary Kaminsky
Publikováno v:
Molecular psychiatry
Alcohol Use Disorder (AUD) is a common and chronic disorder with substantial effects on personal and public health1. The underlying pathophysiology is poorly understood but strong evidence suggests significant roles of both genetic and epigenetic com
Autor:
Silvia Beurmann, Lia J. Zallar, Claire M. Fraser, Brendan J. Tunstall, George F. Koob, Leandro F. Vendruscolo, Lorenzo Leggio
Publikováno v:
Journal of Neuroendocrinology. 31
Ghrelin is a gastric hormone that has been implicated in the neurobiology of alcohol drinking. We have recently developed a ghrelin receptor (growth hormone secretagogue receptor; GHSR) knockout (KO) rat model, which exhibits reduced food consumption
Autor:
Sam A. McConnell, Brandon A. Blank, Brendan J. Tunstall, Leandro F. Vendruscolo, George F. Koob, Adam J. Brandner, David N. Kearns
Publikováno v:
Neuropharmacology
Opioid use disorder imposes great societal harm in the United States and in countries worldwide. Animal models that accurately capture motivational changes that occur in opioid dependence are critical to studying this disorder. The present study used
Autor:
Priscila Darakjian, Leandro F. Vendruscolo, Carolina L. Haass-Koffler, Lorenzo Leggio, Giovanni Addolorato, Markus Heilig, Anna Ferrulli, Estelle Barbier, Robert Hitzemann, Vanessa A. Jimenez, Elie Aoun, Kathleen A. Grant, N. A. R. Walter, George F. Koob, Mary R. Lee
Publikováno v:
Molecular psychiatry
Aldosterone regulates electrolyte and fluid homeostasis through binding to the mineralocorticoid receptors (MRs). Previous work provides evidence for a role of aldosterone in alcohol use disorders (AUDs). We tested the hypothesis that high functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f12f87d293d6957366b59b65b4ca6
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149720
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149720