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Autor:
Peter Illes, Wen-Jing Ren
Publikováno v:
Purinergic Signalling. 18:83-92
Chronic pain is caused by cellular damage with an obligatory inflammatory component. In response to noxious stimuli, high levels of ATP leave according to their concentration gradient, the intracellular space through discontinuities generated in the
Autor:
Kejian Qian, Rui Xiao, Ning Zhao, Ying Yang, Wei Dai, Xiaojin Feng, Wei Peng, Deqiang Luo, Fen Liu, Qiang Shao, Yamei Cui, Chengzhi Ding
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Acute lung injury (ALI) is a common lung pathology that is accompanied by alveolar macrophage (AM) activation and inflammatory response. This study investigated the role of the long non-coding RNA NONRATT004344 (hereafter named lncRNA NLRP3) in regul
Autor:
Mauro Nicollas Oliveira Silverio, Andréia Machado Cardoso, Sarah Franco Vieira de Oliveira Maciel
Publikováno v:
Purinergic Signal
In the last years, it has become evident that both acute and chronic physical exercise trigger responses/adaptations in the purinergic signaling and these adaptations can be considered one important mechanism related to the exercise benefits for heal
Publikováno v:
Journal of Molecular Neuroscience. 72:565-573
As one of the main types of secondary craniocerebral injury, the onset, progression, and prognosis of chronic subdural hematoma (CSDH) are closely related to the local inflammation of intracranial hematoma. Atorvastatin is reported to be effective in
Publikováno v:
Metabolic Brain Disease. 36:2243-2253
Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a prospective target for pain management. Under acute pain conditions in rodents, however, no definitive conclusions about effects of systemically intervening NOP
Autor:
Ze Fan, Jinming Zhang, Feifei Xu, Zuo Wenqiang, Zongping Fang, Jing Han, Wugang Hou, Hailong Dong, Jiao Deng, Jianshuai Zhao, Guo Yaru, Lize Xiong
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Background Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechanism of PND is unclear, and no effective therapies are currently available. It is believed that neuroin
Publikováno v:
Journal of Molecular Neuroscience. 72:48-55
Postoperative cognitive dysfunction (POCD) is a major postoperative neurological complication in children and the elderly. However, the detailed mechanisms underlying this process remain unclear. This study aims to investigate the effect of pleiotrop
Autor:
Masayoshi Tanaka, Junichi Nabekura, Yuri Hirayama, Kozo Saito, Eiji Shigetomi, Yosuke Danjo, Sun Kwang Kim, Yuto Kubota, Bijay Parajuli, Ji Hwan Lee, Youichi Shinozaki, Hiroaki Nagatomo, Schuichi Koizumi
Publikováno v:
Glia. 69:2546-2558
Metabotropic glutamate receptor 5 (mGluR5) in astrocytes is a key molecule for controlling synapse remodeling. Although mGluR5 is abundant in neonatal astrocytes, its level is gradually down-regulated during development and is almost absent in the ad
Autor:
Shinghung Mak, Rongbiao Pi, Hongjun Fu, Wei Cui, Yuan Ping Pang, Yifan Han, Paul R. Carlier, Wenming Li, Shengquan Hu, Karl Wah Keung Tsim, Jialie Luo
Publikováno v:
J Neurochem
Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are devastating diseases in the elderly world, which are closely associated with progressive neuronal loss induced by a variety of genetic and/or environmental factors.
Autor:
Shengnan Yang, Ziyang Hong, Qinglin Tan, Jinke Zhuge, Qiang Zuo, Xuxian Zhong, Jing Guo, Qiong Deng, Jiaqi Liao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Trastuzumab resistance negatively influences the clinical efficacy of the therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and the underlying mechanisms remain elusive. Exploring the mechanisms and finding eff