Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yuji Ikegaya"'
Autor:
Takahiro Adachi, Yuya Nishimura, Takuya Sasaki, Hajime Karasuyama, Yota Fukuda, Soichiro Yoshikawa, Naomi Osakabe, Toya Okonogi, Yuji Ikegaya
Publikováno v:
Biochemical and Biophysical Research Communications. 524:340-345
The brain-gut axis which is an interaction between recognition and emotion and the gut sensory system for food and microbiota is important for health. However, there is no real-time monitoring system of the brain and the gut simultaneously so far. We
Publikováno v:
Journal of neurophysiology. 125(4)
Mean firing rates vary across neurons in a neuronal network. Although most neurons infrequently emit spikes, a small fraction of neurons exhibit extremely high frequencies of spikes; this fraction of neurons plays a pivotal role in information proces
Publikováno v:
Neuropsychopharmacology Reports
Aim The accumulation of amyloid beta (Aβ) is one of the characteristics of Alzheimer's disease. The excessive accumulation of Aβ has been suggested to result in a decrease in the number of synapses. Although the number of synapses is generally modu
Publikováno v:
Biochemical and Biophysical Research Communications. 513:300-305
Human induced-pluripotent stem cell (hiPSC)-derived neurons develop organized neuronal networks under in vitro cultivation conditions. Here, using a multielectrode array system, we examined whether the spike patterns of hiPSC-derived neuronal populat
Publikováno v:
Biochemical and biophysical research communications. 526(3)
The precise and early assessment of cardiotoxicity is fundamental to bring forward novel drug candidates to the pharmaceutical market and to avoid their withdrawal from the market. Recent preclinical studies have attempted to use human-induced plurip
Autor:
Yuji Ikegaya, Tomoe Ishikawa
Publikováno v:
Science Advances
Adjacent CA1 dendritic spines are sequentially and repeatedly activated during hippocampal sharp-wave ripples.
The sequential reactivation of memory-relevant neuronal ensembles during hippocampal sharp-wave (SW) ripple oscillations reflects cogn
The sequential reactivation of memory-relevant neuronal ensembles during hippocampal sharp-wave (SW) ripple oscillations reflects cogn
Autor:
Takuya Terai, Yuji Ikegaya, Shodai Takahashi, Yasuteru Urano, Kazuhisa Hirabayashi, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, Takahiro Egawa, Chiaki Kobayashi, Toru Komatsu
Publikováno v:
Cell Calcium. 60:256-265
Fluorescence imaging of calcium ions (Ca(2+)) has become an essential technique for investigation of signaling pathways involving Ca(2+) as a second messenger. But, Ca(2+) signaling is involved in many biological phenomena, and therefore simultaneous
Autor:
Takashi Sakurai, Kazunori Kanemaru, Junji Suzuki, Yuji Ikegaya, Yoshinori Mikami, Yohei Okubo, Takuya Nakaune, Nobuhito Saito, Masamitsu Iino, Sho Kakizawa, Ryuta Koyama, Toshiko Yamazawa, Hiroki Sugiyama, Kazuki Shibata, Akihiro Ito, Takashi Murayama
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 253-261 (2016)
EBioMedicine
EBioMedicine
Status epilepticus (SE) is a life-threatening emergency that can cause neurodegeneration with debilitating neurological disorders. However, the mechanism by which convulsive SE results in neurodegeneration is not fully understood. It has been shown t
Autor:
Shota Morikawa, Haruki Takeuchi, Risako Nakano, Ai Nakashima, Masato T. Kanemaki, Naoki Ihara, Yuji Ikegaya
Publikováno v:
Neuroreport. 30(13)
Genetic manipulation of protein levels is a promising approach to identify the function of a specific protein in living organisms. Previous studies demonstrated that the auxin-inducible degron strategy provides rapid and reversible degradation of var
Publikováno v:
Neuroreport. 30(3)
The transplantation of human-induced pluripotent stem cell (hiPSC)-derived cells has emerged as a potential clinical approach for the treatment of brain diseases. Recent studies with animal disease models have shown that hiPSC-derived neurons transpl