Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Xiaohan Lu"'
Autor:
Xiyang Liu, Chuanming Xu, Sunhapas Soodvilai, Xiaohan Lu, Fei Wang, Kexin Peng, Tianxin Yang, Renfei Luo
Publikováno v:
Am J Physiol Renal Physiol
We have previously shown that activation of (pro)renin receptor (PRR) induces epithelial Na+channel (ENaC) activity in cultured collecting duct cells. Here, we examined the role of soluble PRR (sPRR), the cleavage product of PRR in ENaC regulation, a
Autor:
Bo Yang, Xiaohan Lu, Jamie R. Privratsky, Jiafa Ren, Steven D. Crowley, Lili Fu, Changlin Mei
Publikováno v:
Am J Physiol Renal Physiol
Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased chemokines, cytokines, and growth factors in the diseased kidney. We found that both isoforms of IL-1, IL-1α and IL-1β, were upregulated in ADPKD tissues. Here, we us
Autor:
Yi Wen, Gianna E. Hammer, Nathan P. Rudemiller, Matthew A. Sparks, Jamie R. Privratsky, Jiafa Ren, Xiaohan Lu, Bo Yang, Steven D. Crowley, Robert Griffiths
Publikováno v:
Circ Res
Rationale: The ubiquitin-editing protein A20 in dendritic cells (DCs) suppresses NF-κB (nuclear factor-κB) signaling and constrains DC-mediated T-cell stimulation, but the role of A20 in modulating the hypertensive response requires elucidation. Ob
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F245-F253
The (pro)renin receptor (PRR) is abundantly expressed in the collecting duct (CD) and the expression is further induced by angiotensin II (ANG II). The present study was conducted to investigate the role of CD PRR during ANG II-induced hypertension a
Autor:
Steven D. Crowley, Alexander D. Jeffs, Yi Wen, Nathan P. Rudemiller, Xiaohan Lu, Jamie R. Privratsky, Jiafa Ren, Jiandong Zhang, Robert Griffiths
Publikováno v:
Am J Pathol
Most forms of chronic kidney disease culminate in renal fibrosis that heralds organ failure. In contrast to the protective effects of globally blocking type 1 angiotensin (AT(1)) receptors throughout the body, activating AT(1) receptors directly on i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2f678dd7868b3b3eb182d33e891faf
https://europepmc.org/articles/PMC6521889/
https://europepmc.org/articles/PMC6521889/
Autor:
Renfei Luo, Tianxin Yang, Donald E. Kohan, Chuanming Xu, Long Zhao, Fei Wang, Chang-Jiang Zuo, Nirupama Ramkumar, Shiying Xie, Xiaohan Lu, Kexin Peng
Publikováno v:
JCI insight. 4(7)
The antidiuretic hormone vasopressin (AVP), acting through its type 2 receptor (V(2)R) in the collecting duct (CD), critically controls urine concentrating capability. Here, we report that site-1 protease–derived (S1P-derived) soluble (pro)renin re
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 69(2)
A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying mechanism largely remains unknown. The major goal of the present study was to test the role of renal (pro)renin receptor (PRR) in this model. In Sprague–Dawley
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 64(2)
Angiotensin II (Ang II) stimulates (pro)renin receptor (PRR) expression in the renal collecting duct, triggering the local renin response in the distal nephron. Our recent study provided evidence for involvement of cyclooxygenase-2–prostaglandin E