Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rossella Manfredini"'
Autor:
Chiara Rossi, Roberta Zini, Sebastiano Rontauroli, Samantha Ruberti, Zelia Prudente, Greta Barbieri, Elisa Bianchi, Simona Salati, Elena Genovese, Niccolò Bartalucci, Paola Guglielmelli, Enrico Tagliafico, Vittorio Rosti, Giovanni Barosi, Alessandro M. Vannucchi, Rossella Manfredini, the AGIMM (AIRC‐Gruppo Italiano Malattie Mieloproliferative) investigators
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by an excessive production of pro-inflammatory cytokines resulting in chronic inflammation and genomic instability. Besides the driver mutations in JAK2, MPL, and CALR genes,
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Autor:
Anette-Gabriele Ziegler, Isabelle Serr, Adam M. Zahm, Saverio Bellusci, Katharina Gerlach, Martin G. Scherm, Victoria K. Salb, Rossella Manfredini, Benno Weigmann, Carolin Daniel, Jonathan Schug, Klaus H. Kaestner
Publikováno v:
Nat. Commun. 10:5697 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536d3d68712489a059ba724008a1e14
https://hdl.handle.net/11380/1221487
https://hdl.handle.net/11380/1221487
Autor:
Anna, Chorzalska, John, Morgan, Nagib, Ahsan, Diana O, Treaba, Adam J, Olszewski, Max, Petersen, Nathan, Kingston, Yan, Cheng, Kara, Lombardo, Christoph, Schorl, Xiaoqing, Yu, Roberta, Zini, Annalisa, Pacilli, Alexander, Tepper, Jillian, Coburn, Anita, Hryniewicz-Jankowska, Ting C, Zhao, Elena, Oancea, John L, Reagan, Olin, Liang, Leszek, Kotula, Peter J, Quesenberry, Philip A, Gruppuso, Rossella, Manfredini, Alessandro Maria, Vannucchi, Patrycja M, Dubielecka
Publikováno v:
Blood. 132(19)
Although the pathogenesis of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs) is linked to constitutive activation of the JAK-STAT pathway, JAK inhibitors have neither curative nor MPN-stem cell-eradicating potential, indicat
Autor:
Valentina Pennucci, Chiara Rossi, Sebastiano Rontauroli, Roberta Zini, Rossella Manfredini, Simona Salati, Samantha Ruberti, Greta Barbieri, Elisa Bianchi, Ruggiero Norfo
Publikováno v:
Stem cells and development. 25(19)
microRNAs are key regulators of gene expression that control stem cell fate by posttranscriptional downregulation of hundreds of target genes through seed pairing in their 3' untranslated region. In fact, miRNAs tightly regulate fundamental stem cell
Autor:
Simona Salati, Elisa Bianchi, Ruggiero Norfo, Sergio Ferrari, Elena Tenedini, Rossella Manfredini, Enrico Tagliafico, Roberta Zini
Publikováno v:
Blood. 116:e99-e110
The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define its role during the hematopoietic lineage commitment, we silenced c-myb in human CD34+ hematopoietic stem/progenit
Autor:
Sebastiano Rontauroli, Elisa Bianchi, Valentina Pennucci, Jenny Bulgarelli, Rossella Manfredini, Roberta Zini, Ruggiero Norfo, Giorgia Sacchi, Simona Salati, Zelia Prudente, Sergio Ferrari, Samantha Ruberti
Publikováno v:
Cell Death and Differentiation
The transcription factor MYB has a key role in hematopoietic progenitor cells (HPCs) lineage choice, by enhancing erythropoiesis at the expense of megakaryopoiesis. We previously demonstrated that MYB controls erythroid versus megakaryocyte lineage d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8bb7ef7c0853eadeb9531e62e830e0
https://hdl.handle.net/11380/1292028
https://hdl.handle.net/11380/1292028
Autor:
Lara Rossi, Rossella Manfredini, Davide Ferrari, Roberto M. Lemoli, Valentina Salvestrini, Marilena Ciciarello, Roberta Zini
Extracellular nucleotides are potent signaling molecules mediating cell-specific biological functions, mostly within the processes of tissue damage and repair and flogosis. We previously demonstrated that adenosine 5'-triphosphate (ATP) inhibits the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a9e4657fb73b9c3801f1b262921e64
https://hdl.handle.net/11380/979703
https://hdl.handle.net/11380/979703
Autor:
Michele Baccarani, Davide Ferrari, Giorgia Migliardi, Maria Rosaria Ricciardi, Roberta Zini, Rossella Manfredini, Elisa Bianchi, Sara Gulinelli, Sergio Ferrari, Roberto M. Lemoli, Agostino Tafuri, Wanda Piacibello, Francesco Di Virgilio, Simona Salati, Luisa Caione, Valentina Salvestrini, Marco Romano, Lara Rossi
Publikováno v:
Blood; Vol 119
Blood
Blood
Extracellular ATP and UTP nucleotides increase the proliferation and engraftment potential of normal human hematopoietic stem cells via the engagement of purinergic receptors (P2Rs). In the present study, we show that ATP and UTP have strikingly oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2ead111b418b2679896b6834684e27
http://hdl.handle.net/11567/608561
http://hdl.handle.net/11567/608561
Autor:
Sergio Ferrari, Fabrizio Fantini, Luigi Aloe, Rossella Manfredini, Luisa Bracci-Laudiero, Carlo Pincelli, Alexis Grande, Cinzia Sevignani, Alberto Giannetti, Andrea Cossarizza
Publikováno v:
Scopus-Elsevier
Journal of investigative dermatology 103 (1994): 13–18. doi:10.1111/1523-1747.ep12388914
info:cnr-pdr/source/autori:Pincelli C (1), Sevignani C (1), Manfredini R (2), Grande A (2), Fantini F (1), Bracci-Laudiero L (3), Aloe L (3), Ferrari S (2), Cossarizza A (4), Giannetti A (1)./titolo:Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes/doi:10.1111%2F1523-1747.ep12388914/rivista:Journal of investigative dermatology/anno:1994/pagina_da:13/pagina_a:18/intervallo_pagine:13–18/volume:103
Journal of investigative dermatology 103 (1994): 13–18. doi:10.1111/1523-1747.ep12388914
info:cnr-pdr/source/autori:Pincelli C (1), Sevignani C (1), Manfredini R (2), Grande A (2), Fantini F (1), Bracci-Laudiero L (3), Aloe L (3), Ferrari S (2), Cossarizza A (4), Giannetti A (1)./titolo:Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes/doi:10.1111%2F1523-1747.ep12388914/rivista:Journal of investigative dermatology/anno:1994/pagina_da:13/pagina_a:18/intervallo_pagine:13–18/volume:103
Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal kerati
Autor:
Marilina Amabile, Lara Rossi, Ines Martin-Padura, Paola Marighetti, Elisa Bianchi, Cristina Rabascio, Michele Baccarani, Giovanni Martinelli, Sergio Ferrari, Rossella Manfredini, Nicoletta Testoni, Francesco Bertolini, Roberto M. Lemoli, Agostino Tafuri, Roberta Zini, Simona Salati, Fausto Castagnetti, Miriam Fogli, Valentina Salvestrini
We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin−CD34−) hematopoietic stem cells from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular karyotyping and quantitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7a32460976168949e1028f5aea8b0a
https://hdl.handle.net/11380/638358
https://hdl.handle.net/11380/638358