Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mauro Alini"'
Publikováno v:
European Cells & Materials, Vol 41, Pp 616-632 (2021)
In vitro models aim to recapitulate the in vivo situation. To more closely mimic the knee joint environment, current in vitro models need improvements to reflect the complexity of the native tissue. High molecular weight hyaluronan (hMwt HA) is one o
Autor:
David P. Finn, Sibylle Grad, Mauro Alini, Marianna Peroglio, Vaibhav Patil, Abhay Pandit, Leo R. Quinlan, Junxuan Ma
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9725, p 9725 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences
Volume 22
Issue 18
Chronic discogenic back pain is associated with increased inflammatory cytokine levels that can influence the proximal peripheral nervous system, namely the dorsal root ganglion (DRG). However, transition to chronic pain is widely thought to involve
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
In the field of regenerative medicine, considerable advances have been made from the technological and biological point of view. However, there are still large gaps to be filled regarding translation and application of mesenchymal stromal cell (MSC)-
Autor:
Elena, Della Bella, Antoine, Buetti-Dinh, Ginevra, Licandro, Paras, Ahmad, Valentina, Basoli, Mauro, Alini, Martin J, Stoddart
Publikováno v:
International Journal of Molecular Sciences
Despite the huge body of research on osteogenic differentiation and bone tissue engineering, the translation potential of in vitro results still does not match the effort employed. One reason might be that the protocols used for in vitro research hav
Autor:
Majid Safa, Naomi Pötter, Mojtaba Khozaei Ravari, Mohammadreza Baghaban Eslaminejad, Mauro Alini, Shahrbanoo Jahangir, David Eglin, Ali Samadikuchaksaraei, Martin J. Stoddart
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Background Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation process towards hypertrophy t
Autor:
Sebastian Wangler, Lorin Michael Benneker, Daisuke Sakai, Mauro Alini, Sibylle Grad, Marianna Peroglio, Ursula Menzel, Lisbet Haglund
Publikováno v:
Wangler, Sebastian; Peroglio, Marianna; Menzel, Ursula; Benneker, Lorin M.; Haglund, Lisbet; Sakai, Daisuke; Alini, Mauro; Grad, Sibylle (2019). Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response. Spine, 44(23), pp. 1613-1622. Lippincott Williams & Wilkins 10.1097/BRS.0000000000003150
Spine
Spine
Supplemental Digital Content is available in the text Homing of mesenchymal stem cells (MSCs) from the endplate into the intervertebral disc (IVD) has been described as alternative intradiscal application route. Our findings indicate that the homed M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d64ed5a1479f721bfe970e674adcfde
https://boris.unibe.ch/138591/1/Mesenchymal_Stem_Cell_Homing_Into_Intervertebral.2.pdf
https://boris.unibe.ch/138591/1/Mesenchymal_Stem_Cell_Homing_Into_Intervertebral.2.pdf
Autor:
Giovanni Marfia, Moira Paroni, Matteo Beretta, Sibylle Grad, Mauro Alini, Laura Guarnaccia, Stefania Elena Navone, Chiara Cordiglieri, Mauro Pluderi, Marco Locatelli, Marianna Peroglio, Rolando Campanella, Paolo Rampini
Publikováno v:
Osteoarthritis and Cartilage. 26:978-987
Summary Objective The aim of the study is to assess the effects of the neuroinflammatory microenvironment of a mechanically-induced degenerating intervertebral disc (IVD) on neuroinflammatory like cells such as microglia, in order to comprehend the r
Autor:
Zhen Li, Lorin Michael Benneker, Jie Du, Sven Hoppe, Sonja Häckel, Nathalie Garstka, Avner Yayon, Mona Zolfaghar, Mauro Alini, Sibylle Grad, Marianna Peroglio
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5036 (2019)
Häckel, Sonja; Zolfaghar, Mona; Du, Jie; Hoppe, Sven; Benneker, Lorin M.; Garstka, Nathalie; Peroglio, Marianna; Alini, Mauro; Grad, Sibylle; Yayon, Avner; Li, Zhen (2019). Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells. International journal of molecular sciences, 20(20) Molecular Diversity Preservation International MDPI 10.3390/ijms20205036
Volume 20
Issue 20
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5036 (2019)
Häckel, Sonja; Zolfaghar, Mona; Du, Jie; Hoppe, Sven; Benneker, Lorin M.; Garstka, Nathalie; Peroglio, Marianna; Alini, Mauro; Grad, Sibylle; Yayon, Avner; Li, Zhen (2019). Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells. International journal of molecular sciences, 20(20) Molecular Diversity Preservation International MDPI 10.3390/ijms20205036
Volume 20
Issue 20
We investigated the effects of a fibrin-hyaluronic acid hydrogel (FBG&ndash
HA) and fibroblast growth factor 18 (FGF-18) for nucleus pulposus (NP) regeneration. Healthy bovine (n = 4) and human degenerated NP cells (n = 4) were cultured for 14 d
HA) and fibroblast growth factor 18 (FGF-18) for nucleus pulposus (NP) regeneration. Healthy bovine (n = 4) and human degenerated NP cells (n = 4) were cultured for 14 d
Publikováno v:
Tissue Engineering Part A. 24:849-859
Mesenchymal stem cells (MSCs) are considered a promising cell source for cartilage repair strategies due to their chondrogenic differentiation potential. However, their in vitro tendency to progress toward hypertrophy limits their clinical use. This
Autor:
Marcy Zenobi-Wong, David Eglin, Brian D. Cosgrove, Mauro Alini, Claudia Loebel, Robert L. Mauck, Spencer E. Szczesny
Publikováno v:
Biomacromolecules. 18:855-864
Given the significance of hydrogels as cell-instructive materials, it is important to understand how differences in their chemical and physical properties are able to direct cell fate. For example, it remains unclear how different hydrogel cross-link