Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Bruce R. Ransom"'
Autor:
Bing, Ye, Hui, Shen, Jing, Zhang, Yuan-Gui, Zhu, Bruce R, Ransom, Xiao-Chun, Chen, Zu-Cheng, Ye
Publikováno v:
Glia. 63(12)
Oxidative stress plays an important role in the progression of Alzheimer's disease (AD) and other neurodegenerative conditions. Glutathione (GSH), the major antioxidant in the central nervous system, is primarily synthesized and released by astrocyte
Autor:
John Kulman, Henrik Andersen, Thomas Möller, Jonathan R. Weinstein, Jon Kuniyoshi, Uwe Karsten Hanisch, Bruce R. Ransom, Caroline Bishop, Soyon Hong
Publikováno v:
Journal of Neurochemistry. 95:1177-1187
Microglia are the resident immune cells of the CNS. Brain injury triggers microglial activation, leading to proliferation, changes in antigenic profile, NO production and cytokine release. It is widely believed that serum factors inundating the injur
Publikováno v:
The Journal of Neuroscience. 23:3588-3596
Little is known about the expression and possible functions of unopposed gap junction hemichannels in the brain. Emerging evidence suggests that gap junction hemichannels can act as stand-alone functional channels in astrocytes. With immunocytochemis
Publikováno v:
Journal of Neurochemistry. 75:1539-1547
Microglia are the resident immune cells of the CNS. Upon brain damage, these cells are rapidly activated and function as tissue macrophages. The first steps in this activation still remain unclear, but it is widely believed that substances released f
Publikováno v:
Journal of Biological Chemistry. 276:25946-25952
Microglia are the resident tissue macrophages of the central nervous system. They are rapidly activated by a variety of insults; and recently, receptors linked to cytoplasmic Ca(2+) signals have been implicated in such events. One potential class of
Publikováno v:
NeuroReport. 10:2929-2932
Oligodendrocytes are the myelin forming glial cells of the CNS and are known to express receptors linked to ion channels and intracellular second messenger cascades. In this paper, we describe the intracellular calcium responses of cells from the oli
Autor:
Raymond A. Swanson, Kevin Farrell, Maria C. Longuemare, Stephen G. Waxman, Christine R. Rose, Bruce R. Ransom
Publikováno v:
Neuroscience. 93:285-292
Glutamate uptake is coupled to counter-transport of K+, and high external K+ concentrations can induce reversal of glutamate uptake in whole-cell patch-clamp and isolated membrane preparations. However, high external K+ causes little or no reversal o
Publikováno v:
Europe PubMed Central
Rose, Christine R., Bruce R. Ransom, and Stephan G. Waxman. Pharmacological characterization of Na+influx via voltage-gated Na+channels in spinal cord astrocytes. J. Neurophysiol. 78: 3249–3258, 1997. Spinal cord astrocytes display a high density o
Autor:
Christopher A. Pappas, Bruce R. Ransom
Publikováno v:
Journal of Neurophysiology. 72:2816-2826
1. Depolarization of glial cells causes their intracellular pH (pHi) to increase. To more completely characterize this depolarization-induced alkalinization (DIA) in mammalian astrocytes, we studied DIA in cultured rat hippocampal astrocytes. Astrocy
Publikováno v:
Glia. 7:322-328
The development of functional gap-junctional communication was studied in cells of the oligodendrocyte lineage. The presence of cell-cell coupling was determined by the passage of current between cells using a double whole-cell patch-clamp system or