Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Almudena Porras"'
Autor:
Almudena Porras, Celia Sequera, Ana Vázquez-Carballo, María Arechederra, Sonia Fernández-Veledo
Publikováno v:
Journal of Cellular Physiology. 233:968-978
TWEAK regulates multiple physio-pathological processes in fibroblasts such as fibrosis. It also induces migration and invasion in tumors and it can activate p38 MAPK in various cell types. Moreover, p38α MAPK promotes migration and invasion in sever
Autor:
Susana Zuluaga, Manuel Benito, Almudena Porras, Alvaro Gutierrez-Uzquiza, Angel R. Nebreda, Alberto Álvarez-Barrientos, Paloma Bragado
Publikováno v:
FEBS Letters. 581:3819-3825
The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulat
Publikováno v:
Molecular Endocrinology. 12:825-834
Insulin-like growth factor I (IGF-I)/insulin induced cytosolic p42/p44 mitogen-activated protein kinase (MAPK) activation in a time-dependent manner in fetal brown adipocytes, reaching a maximum at 5 min. Concurrently, nuclear p42/p44 MAPKs were also
Autor:
Ramón Muñoz-Chápuli, Aránzazu Sánchez, José M. López-Novoa, Almudena Porras, Carmen Guerrero, Michael D. Schneider, Elena Cano, Flavio Maina, Paloma Bragado, Ignacio Cruz-González, Rita Carmona, Alvaro Gutierrez-Uzquiza, María González-Núñez, María Arechederra
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
instname
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
et al.
Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling
Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling
Publikováno v:
DNA and Cell Biology. 15:921-928
Since Ras proteins are essential intermediates of some insulin-like growth factor I (IGF-I)/insulin signaling pathways, we examined whether Ras proteins mediate the IGF-I-induced uncoupling protein expression. Additionally, the role of Ras proteins o
Autor:
Angel R. Nebreda, Manuel Benito, Susana Zuluaga, Almudena Porras, Alberto Álvarez-Barrientos, Alvaro Gutierrez-Uzquiza
Publikováno v:
Cellular signalling. 19(1)
Cardiomyocyte-derived cell lines deficient in p38alpha are more resistant to apoptosis owing to lower expression of the pro-apoptotic proteins Bax and Fas and upregulation of the ERK survival pathway. Here, we show that increased Akt activity also co
Autor:
Manuel Benito, Blanca Herrera, Isabel Fabregat, Alberto Alvarez, Almudena Porras, Amparo Valladares, Susana Zuluaga
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Trying to define the precise role played by insulin regulating the survival of brown adipocytes, we have used rat fetal brown adipocytes maintained in primary culture. The effect of insulin on apoptosis and the mechanisms involved were assessed. Diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96aeb50a1a771f2febf241a9ecd9d2c8
http://hdl.handle.net/2445/36334
http://hdl.handle.net/2445/36334
Autor:
Almudena Porras, Angel R. Nebreda, Amparo Valladares, Susana Zuluaga, Alberto Alvarez, Manuel Benito, Concetta Ambrosino, Emma Black
Publikováno v:
Molecular biology of the cell. 15(2)
p38 alpha mitogen-activated protein (MAP) kinase is a broadly expressed signaling molecule that participates in the regulation of cellular responses to stress as well as in the control of proliferation and survival of many cell types. We have used ce
Autor:
Almudena Porras, Blanca Herrera, Isabel Fabregat, Margarita Fernández, Amparo Valladares, Manuel Benito, Juan-Jose Ventura, César Roncero
Publikováno v:
FEBS letters. 499(3)
We have previously found that transforming growth factor-beta (TGF-beta) induces an increase in radical oxygen species (ROS) production that mediates its apoptotic effects in fetal hepatocytes. In this paper we show that TGF-beta activates p38 mitoge
Autor:
Almudena Porras, Amparo Valladares, César Roncero, Alberto Alvarez, Manuel Benito, Juan-Jose Ventura
Publikováno v:
Endocrinology. 141(12)
Tumor necrosis factor-α (TNFα) induces apoptosis and cell growth inhibition in primary rat fetal brown adipocytes. Here, we examine the role played by some members of the mitogen-activated protein kinase (MAPK) superfamily. TNFα activates extracel