Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Tetsuya Hosooka"'
Autor:
Tetsuya, Hosooka, Yusei, Hosokawa, Kaku, Matsugi, Masakazu, Shinohara, Yoko, Senga, Yoshikazu, Tamori, Chikako, Aoki, Sho, Matsui, Tsutomu, Sasaki, Tadahiro, Kitamura, Masashi, Kuroda, Hiroshi, Sakaue, Kazuhiro, Nomura, Kei, Yoshino, Yuko, Nabatame, Yoshito, Itoh, Kanji, Yamaguchi, Yoshitake, Hayashi, Jun, Nakae, Domenico, Accili, Takehiko, Yokomizo, Susumu, Seino, Masato, Kasuga, Wataru, Ogawa
Publikováno v:
Proc Natl Acad Sci U S A
Although adipocytes are major targets of insulin, the influence of impaired insulin action in adipocytes on metabolic homeostasis remains unclear. We here show that adipocyte-specific PDK1 (3′-phosphoinositide–dependent kinase 1)-deficient (A-PDK
Autor:
Kazuki Yasuda, Yasushi Matsuki, Michihiro Matsumoto, Mashito Sakai, Tetsuya Noguchi, Ryuji Hiramatsu, Hiroshi Inoue, Kazuo Takazawa, Tetsuya Hosooka, Masato Kasuga, Yoshiaki Kido, Tomoko Tujimura, Kenjiro Inagaki, Cao Yongheng
Publikováno v:
Nature Medicine. 18:612-617
During fasting, induction of hepatic gluconeogenesis is crucial to ensure proper energy homeostasis. Such induction is dysregulated in type 2 diabetes, resulting in the development of fasting hyperglycemia. Hormonal and nutrient regulation of metabol