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Autor:
Beata M. Wolska, Pieter P. de Tombe, Montamas Suntravat, R. John Solaro, Tuchakorn Lertwanakarn, Elda E. Sánchez, Kittipong Tachampa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-00282-x⟩
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-00282-x⟩
Scientific Reports
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-00282-x⟩
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-00282-x⟩
Beta-cardiotoxin (β-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel β-adrenergic blocker. However, the involvement of β-adrenergic signaling by this compound has never been elucidated. The objectives of this
Publikováno v:
J Physiol
Pulmonary hypertension is characterized by sustained vasoconstriction and remodelling of the small pulmonary arteries, which is associated with persistent depolarization of the resting membrane potential (Em ) of pulmonary arterial smooth muscle cell
Publikováno v:
Journal of Hypertension. 40:117-127
Background We earlier demonstrated that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit the overexpression of Giα proteins and hyperproliferation that is attributed to the enhanced levels of endogenous II angio
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48:1336-1345
Policosanol is a hypocholesterolemic derived from sugar cane and corn that downregulates blood cholesterol levels. It can further lower blood pressure and reduce liver inflammation. Policosanol can also affect vascular calcification, however, its mol
Autor:
Anton Popelka, Huseyin C. Yalcin, Mahmoud Khatib A A Al-Ruweidi, Fatma Hassan Ali, Samar Shurbaji
Publikováno v:
Journal of Applied Physiology
Many patients who suffer from pulmonary diseases cannot inflate their lungs normally, as they need mechanical ventilation (MV) to assist them. The stress associated with MV can damage the delicate epithelium in small airways and alveoli, which can ca
Publikováno v:
Journal of Cellular Physiology. 236:5176-5192
TMEM173 has been reported to participate in endoplasmic reticulum stress, inflammation and immunology, all of which closely involved with cardiac hypertrophy. But its role in autophagy is not fully figured out. In our research, Tmem173 global knockou
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 319:E1112-E1120
Neuronal control of the energy homeostasis requires the arcuate nucleus of the hypothalamus. This structure integrates peripheral and central signals concerning the energy state of the body. It comprises two populations of neurons releasing anorexige
Publikováno v:
Journal of Vascular Research. 57:24-33
Aim: Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but the exact mechanisms remain unclear. The purpose of this study was to investigate the mechanisms behind and related to aortic fibrosis and aortic sti
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Statins are prescribed for prevention and treatment of coronary artery disease. Statins have different cholesterol lowering abilities, with rosuvastatin and atorvastatin being the most effective, while statins like simvastatin and fluvastatin having
Autor:
Limei Liu, Shi Jia, Chunling Xu, Ruxia Liu, Xingzhong Zhang, Yangpo Cao, Qihua He, Jingjing Ye, Xue Qiao, Yingying Liu, Lin Weng, Cheng-Lin Zhang, Ming Zheng
Publikováno v:
Circulation Research. 125:728-743
Rationale: The constrained mitochondria in cardiomyocytes communicate with each other, through mitochondrial kissing or nanotunneling, forming a dynamically continuous network to share content and transfer signals. However, the molecular mechanism of