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Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 319:E1112-E1120
Neuronal control of the energy homeostasis requires the arcuate nucleus of the hypothalamus. This structure integrates peripheral and central signals concerning the energy state of the body. It comprises two populations of neurons releasing anorexige
Autor:
Naweed I. Syed, Tiffany Rice, Marcus Pehar, Timothy E. Shutt, Andrew J. Thompson, Kiana Jahanbakhsh, P.V.S. Machiraju, Fahad Iqbal, Shadab Batool, Rasha Sabouny, Jennifer Chow, Jane Shearer, Kamran Yusuf, Urva Azeem, Atika Syeda, Nerea Jimenez-Tellez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Anesthetics are deemed necessary for all major surgical procedures. However, they have also been found to exert neurotoxic effects when tested on various experimental models, but the underlying mechanisms remain unknown. Earlier studies have implicat
Publikováno v:
Physiological Reports
Previous work has shown that cannabinoids increase feeding, while cholecystokinin (CCK) has an anorexigenic effect on food intake. Receptors for these hormones are located on cell bodies of vagal afferent nerves in the nodose ganglia. An interaction
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C748-C754
The roles of nicotine on Ca2+ oscillations [intracellular Ca2+ ([Ca2+]i) oscillation] in rat primary cultured cortical neurons were studied. The spontaneous [Ca2+]i oscillations (SCO) were recorded in a portion of the neurons (65%) cultured for 7–1
Autor:
Ellen M. Unterwald, Jeffrey L. Barr, G. Cristina Brailoiu, Pingwei Zhao, Eugen Brailoiu, Guang Yan, Elena Deliu, Mary E. Abood
Publikováno v:
Cell Calcium. 58:196-207
Cocaine promotes addictive behavior primarily by blocking the dopamine transporter, thus increasing dopamine transmission in the nucleus accumbens (nAcc); however, additional mechanisms are continually emerging. Sigma-1 receptors (σ 1 Rs) are known
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 6, Pp 2329-2337 (2018)
Background/Aims: Sevoflurane, a commonly used volatile anesthetic, recently has been found has neurotoxicity in the central nervous system of neonatal rodents. This study aimed to reveal whether phosphodiesterase 4 (PDE-4) inhibitor roflumilast has p
Autor:
Vimal Bansal, Thomas E. Fisher
Publikováno v:
Physiological Reports
The magnocellular neurosecretory cells (MNCs) of the hypothalamus regulate body fluid balance by releasing the hormones vasopressin (VP) and oxytocin (OT) in an osmolality‐dependent manner. Elevations of external osmolality increase MNC firing and
Publikováno v:
Physiological research. 66(3)
Bis(3)-tacrine is a dimeric AChE inhibitor derived from tacrine with a potential to treat Alzheimer’s disease. It was recently been reported to act as a fast off-rate antagonist of NMDA receptors with moderate affinity. In the present study, we aim
Autor:
Yonghao Yu, Zhifen Wang, Yuan Yuan, Guolin Wang, Zhe Sun, Yi Chen, Keliang Xie, Ying He, Yuxin Zheng
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171348 (2017)
PLoS ONE
PLoS ONE
Remifentanil-induced secondary hyperalgesia has been demonstrated in both animal experiments and clinical trials. Enhancement of N-methyl-D-aspartate (NMDA) receptor trafficking as well as protein kinase C (PKC) and calmodulin-dependent protein kinas
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 6, Pp 1715-1732 (2014)
Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood. Methods: Immature rat h