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Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Statins are prescribed for prevention and treatment of coronary artery disease. Statins have different cholesterol lowering abilities, with rosuvastatin and atorvastatin being the most effective, while statins like simvastatin and fluvastatin having
Autor:
Igor Khaliulin, Frantisek Kolar, M-Saadeh Suleiman, Leonid N. Maslov, Yury B. Lishmanov, N. V. Naryzhnaya, Sergey Y Tsibulnikov
Publikováno v:
Naryzhnaya, N V, Khaliulin, I, Lishmanov, Y B, Suleiman, M-S, Tsibulnikov, S, Kolar, F & Maslov, L N 2019, ' Participation of opioid receptors in the cytoprotective effect of chronic normobaric hypoxia ', Physiological Research, vol. 68, no. 2, pp. 245-253 . https://doi.org/10.33549/physiolres.933938
We studied the role of the delta, micro, and kappa opioid receptor (OR) subtypes in the cardioprotective effect of chronic continuous normobaric hypoxia (CNH) in the model of acuteanoxia-reoxygenation of isolated cardiomyocytes. Adaptation of rats to
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C554-C568
Studies have demonstrated the therapeutic potential of estrogen metabolite 2-methoxyestradiol (2ME2) in several cardiovascular disorders, including hypertension. However, the exact mechanism(s) remains unknown. In this study, primary rat aortic smoot
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 2, Pp 598-608 (2017)
Background: Statins can reduce reproductive damage induced by obesity or high-fat diet (HFD), but the specific regulatory mechanisms are largely unknown. Since mTOR/p70s6k sinaling promotes spermatogonia proliferation and spermatogenesis, we hypothes
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES. 46(12)
It has been shown that both nilotinib as a tyrosine kinase inhibitor, and atorvastatin as a rho-kinase inhibitor, have antifibrotic effects. Therefore, considering the relationship between these two pathways, this study aimed to investigate the effec
Publikováno v:
Physiological Reports
Previous work has shown that cannabinoids increase feeding, while cholecystokinin (CCK) has an anorexigenic effect on food intake. Receptors for these hormones are located on cell bodies of vagal afferent nerves in the nodose ganglia. An interaction
Autor:
Lin Zhou, Yukai Liu, Wei E. Wang, Hongmei Ren, Caiyu Chen, Xinjian Chen, Chunyu Zeng, Shuo Zheng
Publikováno v:
Journal of Hypertension. 34:1599-1606
Background Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 r
Autor:
Yao Liang Tang, Jian Peng Teoh, Neal L. Weintraub, Kyoung-mi Park, Ahmed S. Bayoumi, Il-man Kim, Zuzana Broskova, Yongchao Wang, Huabo Su
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H371-H383
The nonselective β-adrenergic receptor antagonist (β-blocker) carvedilol has been shown to protect against myocardial injury, but the detailed underlying mechanisms are unclear. We recently reported that carvedilol stimulates the processing of micr
Autor:
Yanli Zhou, Shutong Shen, Xinli Li, Shan-Shan Li, Qi Sun, Qiulian Zhou, Yihua Bei, Haifeng Zhang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 5, Pp 1743-1751 (2016)
Background/Aims: Qiliqiangxin (QL), a traditional Chinese medicine, has long been used to treat chronic heart failure. Previous studies demonstrated that QL could prevent cardiac remodeling and hypertrophy in response to hypertensive or ischemic stre
Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells
Autor:
Kanako Ogura-Ochi, Motoshi Komatsubara, Jun Wada, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Yuki Nishiyama, Satoshi Fujisawa
Publikováno v:
Peptides. 94
The effects of melatonin on prolactin production and its regulatory mechanism remain uncertain. We investigated the regulatory role of melatonin in prolactin production using rat pituitary lactotrope GH3 cells by focusing on the bone morphogenetic pr