Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Priya Chatterji, Veronique Giroux, E. Paul Wileyto, Anil K. Rustgi, Kathryn E. Hamilton, Ben Rhoades, Christopher J. Lengner, Julien Stephan, Andres J. Klein-Szanto
Publikováno v:
Stem Cell Reports
Summary Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside
Autor:
Kathryn E. Hamilton, Koji Tanaka, Veronique Giroux, Hiroshi Nakagawa, Marie Pier Tetreault, Ju Seog Lee, Apple Long, Andres J. Klein-Szanto, Anil K. Rustgi, Kelly A. Whelan
Publikováno v:
Carcinogenesis. 36:598-606
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We h
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes
Autor:
Jacqueline Morris, Terri Schochet, Min-Sun Kim, Anil K. Rustgi, James Eberwine, Jai-Yoon Sul, Andres J. Klein-Szanto
Publikováno v:
Human Pathology. 44:766-776
Summary Elk-1 is a member of the Ets family of transcription factors, which are identified by a conserved Ets DNA-binding domain that mediates transcriptional regulation at Ets sequence--containing promoters. The activation domain of Elk-1 is importa
Autor:
Xiang Xi Xu, Andrew K. Godwin, Andres J. Klein-Szanto, Ying Wang, Toni M. Yeasky, Elizabeth R. Smith, Thomas C. Hamilton, Robert B. Moore, Parvin Ganjei-Azar, Kathy Q. Cai
Publikováno v:
Molecular and cellular biology. 36(18)
We modeled the etiology of postmenopausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, incorporating oncogenic mutations. Ovarian cancer incidence is highest in peri- and postmenopausal women, and epidemi
Autor:
Olena Barbash, Anil K. Rustgi, Mariusz A. Wasik, Andres J. Klein-Szanto, Laura Pontano Vaites, Darshan Roy, J A Diehl, Zhaorui Lian, Eric K. Lee
Publikováno v:
Molecular and Cellular Biology. 31:4513-4523
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replicat
Publikováno v:
Gynecologic Oncology. 114:18-25
Tp53 mutation is frequent and associates with malignant, high-grade ovarian cancer. However, the details about the progression of Tp53 mutation from heterozygous to homozygous, and association between genotypes and morphological transformation are no
Autor:
Andres J. Klein-Szanto, Elizabeth P. Henske, Tiffiney R. Hartman, Emmanuelle Nicolas, Tahseen Al-Saleem, T P Cash, M. C. Simon
Publikováno v:
Oncogene. 28:1594-1604
Birt-Hogg-Dubé (BHD) syndrome is a tumor-suppressor gene disorder characterized by skin tumors, cystic lung disease and renal cell carcinoma. Very little is known about the molecular pathogenesis of BHD. Clinical similarities between BHD and tuberou
Publikováno v:
Journal of Clinical Investigation. 118:111-123
Preclinical data support the potential of the death-signaling receptors for TRAIL as targets for cancer therapy. However, it is unclear whether these death-signaling receptors suppress the emergence and growth of malignant tumors in vivo. Herein we s
Autor:
Claudia D. Andl, Anil K. Rustgi, Andres J. Klein-Szanto, Douglas B. Stairs, Jiri Kalabis, Hiroshi Nakagawa, Cameron N. Johnstone, Wafik S. El-Deiry, Takaomi Okawa, Edna Cukierman, Carmen Z. Michaylira, Meenhard Herlyn
Publikováno v:
Genes & Development. 21:2788-2803
Esophageal cancer is a prototypic squamous cell cancer that carries a poor prognosis, primarily due to presentation at advanced stages. We used human esophageal epithelial cells as a platform to recapitulate esophageal squamous cell cancer, thereby p