Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christian Gaiddon"'
Autor:
Shireen Jozi, Jason R. Smith, Ryan M. Clarke, Christian Gaiddon, Jeffrey J. Warren, Tim Storr, Jessica J. Miller, Anais Blanchet, Christophe Orvain
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
Chemistry-A European Journal, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
International audience; The p53 protein plays a major role in cancer prevention, and over 50 % of cancer diagnoses can be attributed to p53 malfunction. The common p53 mutation Y220C causes local protein unfolding, aggregation, and can result in a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272afda3c0914f96547ca96b5aac60ec
http://summit.sfu.ca/item/19848
http://summit.sfu.ca/item/19848
Autor:
Kwan Wei Tan, Mun Juinn Chow, Mei Chi Cheong, Christian Gaiddon, Wee Han Ang, Giorgia Pastorin, Maria V. Babak
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, American Chemical Society, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, American Chemical Society, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
International audience; Current anticancer drug discovery efforts focus on the identification of first-in-class compounds with a mode-of-action distinct from conventional DNA-targeting agents for chemotherapy. An emerging trend is the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127630819ea87a98410b91db57739f58
https://www.hal.inserm.fr/inserm-02364152/document
https://www.hal.inserm.fr/inserm-02364152/document
Autor:
Cynthia Licona, François Delalande, Moussa Ali, Marie-Elodie Spaety, Georg Mellitzer, John Spencer, Christian Gaiddon, Antonelle Capuozzo, Sarah Cianférani, Alain Van Dorsselaer, Rita Santamaria, Olivier Armant, Michel Pfeffer
Publikováno v:
OncoTarget, 8 (2), 2568-2584
Oncotarget
Oncotarget, Impact journals, 2017, 8 (2), pp.2568-2584. ⟨10.18632/oncotarget.13711⟩
Oncotarget
Oncotarget, Impact journals, 2017, 8 (2), pp.2568-2584. ⟨10.18632/oncotarget.13711⟩
Ruthenium complexes are considered as potential replacements for platinum compounds in oncotherapy. Their clinical development is handicapped by a lack of consensus on their mode of action. In this study, we identify three histones (H3.1, H2A, H2B) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cca12dabc9bc035e381120b54ac9ad3
Autor:
Samir Benosman, Christian Gaiddon, Isabelle Gross, Koji Okamoto, Aart G. Jochemsen, Clarke N, J P Loeffler
Publikováno v:
Cell Death & Differentiation. 14:2047-2057
MDMX has been shown to modulate p53 in dividing cells after DNA damage. In this study, we investigated the role of MDMX in primary cultures of neurons undergoing cell death. We found that DNA damage, but also membrane-initiated apoptotic stresses (gl
Autor:
Jonathan D. Licht, Olivier Armant, Michèle Kedinger, J L G de Aguilar, Samir Benosman, J-N Freund, Isabelle Gross, Christian Gaiddon, J P Loeffler
Publikováno v:
Cell Death & Differentiation. 14:1802-1812
Sprouty (Spry) proteins are ligand-inducible inhibitors of receptor tyrosine kinases-dependent signaling pathways, which control various biological processes, including proliferation, differentiation and survival. Here, we investigated the regulation
Autor:
Yannick von Grabowiecki, Vania Vidimar, Cynthia Licona, Djalil Coowar, Georg Mellitzer, Paula Abreu, Lavinia Palamiuc, Christian Gaiddon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(1)
Muscular atrophy, a physiopathologic process associated with severe human diseases such as amyotrophic lateral sclerosis (ALS) or cancer, has been linked to reactive oxygen species (ROS) production. The Notch pathway plays a role in muscle developmen
Autor:
Cynthia Licona, Daniel Yuan Qiang Wong, Christian Gaiddon, Giorgia Pastorin, Mun Juinn Chow, Wee Han Ang
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2014, 57 (14), pp.6043-6059. ⟨10.1021/jm500455p⟩
Journal of Medicinal Chemistry, American Chemical Society, 2014, 57 (14), pp.6043-6059. ⟨10.1021/jm500455p⟩
Journal of Medicinal Chemistry, 2014, 57 (14), pp.6043-6059. ⟨10.1021/jm500455p⟩
Journal of Medicinal Chemistry, American Chemical Society, 2014, 57 (14), pp.6043-6059. ⟨10.1021/jm500455p⟩
International audience; The structural diversity of metal scaffolds makes them a viable alternative to traditional organic scaffolds for drug design. Combinatorial chemistry and multicomponent reactions, coupled with high-throughput screening, are us
Autor:
Christian Gaiddon, Cynthia Licona, Pascal Hébraud, Marcelina Klajner, Michel Pfeffer, Georg Mellitzer, Sébastien Harlepp, Ludivine Fetzer
Ruthenium-based compounds are developed for anticancer treatment, but their mode of action including their import mechanism and subcellular localization remains elusive. Here, we used the intrinsic luminescent properties of cytotoxic organoruthenium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1e39b555428aa7cd9a2d2a2bdcd65d
Autor:
Anne-Laurence Boutillier, Christian Gaiddon, Emmanuelle Trinh, Jean-Philippe Loeffler, Bernd Sommer, Yves Larmet
Publikováno v:
Journal of neurochemistry. 73(4)
To investigate the molecular mechanisms underlying brain-derived neurotrophic factor (BDNF)-controlled synaptic plasticity, we studied beta2-adrenergic receptor (beta2-AR) expression in cultured cerebellar granule cells. We show that, depending on th
Publikováno v:
Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 1996, 66 (6), pp.2279-2286. ⟨10.1046/j.1471-4159.1996.66062279.x⟩
Journal of Neurochemistry, 1996, 66 (6), pp.2279-2286. ⟨10.1046/j.1471-4159.1996.66062279.x⟩
Europe PubMed Central
Journal of Neurochemistry, Wiley, 1996, 66 (6), pp.2279-2286. ⟨10.1046/j.1471-4159.1996.66062279.x⟩
Journal of Neurochemistry, 1996, 66 (6), pp.2279-2286. ⟨10.1046/j.1471-4159.1996.66062279.x⟩
Europe PubMed Central
International audience; Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, regulates survival and apoptosis of several neuronal populations. These effects are initiated by high-affinity membrane receptors displaying tyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb1685c6d2df3e74e57377987499fd1
https://www.hal.inserm.fr/inserm-02360385/document
https://www.hal.inserm.fr/inserm-02360385/document