Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Quansheng Zhou"'
Autor:
Jindan Qi, Mengli Zhang, Yuxi Liu, Wei Lu, Quansheng Zhou, Yingnan Qiao, Mei Meng, Zhou Zhou, Peng Xu, Yanxing Hu, Zhe Zhao
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Background Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic. Methods We used TNBC cells and xenografted mice as models to explore
Autor:
Mengli Zhang, Di Yu, Bin Zhang, Zhifei Cao, Pan Zhang, Zhe Zhao, Shijie Tan, Chunping Lv, Quansheng Zhou
Publikováno v:
Toxicology and Applied Pharmacology. 365:1-8
Lung cancer is a leading lethal disease with a 5-year survival rate of only 16%. Inadequate potent anti-cancer drugs appear to be a bottleneck in the treatment of lung cancer; hence, how to develop effective anti-lung cancer therapeutics is an urgent
Publikováno v:
Toxicology Letters. 278:9-17
Lyn is a proto-oncogene overexpressed and constitutively activated in lymphoma, and plays an important role in lymphoma initiation and malignant progression. Hence, the oncogenic Lyn has recently been targeted for novel anti-lymphoma drug discovery;
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1866:12-22
F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein) E3 ligase complexes, play critical roles in the development and progression of human malignancies through governing multiple cellular processes including cell p
Publikováno v:
Toxicology and applied pharmacology. 388
Gastric cancer ranks as the third leading cause of cancer-related death worldwide. The uncontrolled tumor growth and robust metastasis are key factors to cause the cancer patient death. Mechanistically, aberrant activation of Notch and NF-κB signali
Publikováno v:
Journal of cellular physiology. 234(7)
Metastatic melanoma accounts for 60% of death for skin cancer. Although great efforts have been made to treat the disease, effective drugs against metastatic melanoma still lack at the clinical setting. In the current study, we found that lycorine, a
Publikováno v:
Biochemical pharmacology. 126
Leukemia cells aberrantly overexpress senescence-suppression telomerase reverse transcriptase (TERT) and down-regulate key senescence-promoting genes to escape complete senescence, resulting in immortalization and malignant progression. Accordingly,
Autor:
Ping Yang, Quansheng Zhou, Zihe Huo, Shilong Fu, Yanyan Pan, Gaochuan Zhang, Zhifei Cao, Aidi Gao, Huaidong Liao
Publikováno v:
Toxicology and applied pharmacology. 288(2)
Cancer cells have both tumor-adaptive and -suppressive endoplasmic reticulum (ER) stress machineries that determine cell fate. In malignant tumors including lymphoma, constant activation of tumor-adaptive ER stress and concurrent reduction of tumor-s
Autor:
Shilong Fu, Gaochuan Zhang, Quansheng Zhou, Di Yu, Wenming Liu, Meimei Bao, Zhifei Cao, Yanyan Pan
Publikováno v:
Toxicology letters. 226(3)
Uncontrolled cell proliferation and robust angiogenesis play critical roles in osteosarcoma growth and metastasis. In this study we explored novel agents derived from traditional Chinese medicinal herbs that potently inhibit osteosarcoma growth and m
Autor:
Jian Tu, Di Yu, Zhifei Cao, Ping Yang, Pengda Guo, Quansheng Zhou, Shilong Fu, Yanyan Pan, Gaochuan Zhang, Meimei Bao, Bingxue Shang
Publikováno v:
Toxicology letters. 218(2)
Uncontrolled tumor cell proliferation and robust neovascularization are prominent features of aggressive ovarian cancers. Although great efforts in anti-ovarian cancer therapy have been made in the past 4 decades, the 5-year survival rates for ovaria