Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Yong J. Lee"'
Autor:
Jin Hong Kim, Abdo J. Najy, Jian Li, Xu Luo, Hyeong‐Reh C. Kim, Mohammad Haroon Asif Choudry, Yong J. Lee
Publikováno v:
Journal of Cellular Physiology. 237:4180-4196
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor-mediated extrinsic apoptosis, specifically in cancer cells, and Bid (BH3-interacting domain death agonist) plays an important role in TRAIL-induced apoptosis. Ferr
Autor:
Yong Seok Park, Kalishwaralal Kalimuthu, Yong J. Lee, Ja Lok Ku, Jin Hong Kim, Xu Luo, Lin Zhang, M. Haroon A. Choudry
Publikováno v:
Journal of Cellular Physiology. 236:6666-6677
Abnormalities of the tumor vasculature result in insufficient blood supply and development of a tumor microenvironment that is characterized by low glucose concentrations, low extracellular pH, and low oxygen tensions. We previously reported that glu
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug therapy
Autor:
Hima Makala, Kalishwaralal Kalimuthu, Young Sun Lee, Yong Seok Park, Yong J. Lee, Simon C. Watkins, Yong Tae Kwon, M. Haroon A. Choudry, David L. Bartlett
Publikováno v:
J Cell Physiol
Ferroptosis has been reported as a unique form of cell death. However, in recent years, researchers have increasingly challenged the uniqueness of ferroptosis compared to other types of cell death. In this study, we examined whether ferroptosis share
Autor:
Lisa Bailey, David L. Bartlett, Xinxin Song, Se Hoon Hong, William T. Kwon, Yong J. Lee, Yong Tae Kwon, Per H. Basse
Publikováno v:
Molecular Cancer Therapeutics. 15:1591-1601
Since its discovery in 1995, TNF-related apoptosis-inducing ligand (TRAIL) has sparked growing interest among oncologists due to its remarkable ability to induce apoptosis in malignant human cells, but not in most normal cells. However, one major dra
Autor:
Ashok K. Dilly, Yong J. Lee, Yong Tae Kwon, David L. Bartlett, Haroon A. Choudry, Xinxin Song
Publikováno v:
Molecular Cancer Research. 13:1533-1543
Colorectal peritoneal carcinomatosis (CPC) exhibits severe tumor hypoxia, leading to drug resistance and disease aggressiveness. This study demonstrates that the combination of the chemotherapeutic agent mitomycin C with the proteasome inhibitor bort
Autor:
Joonsung Hwang, Sang Cheul Oh, Shin Hyuk Kang, Ki Sa Sung, Dae Hee Lee, Su Ran Mun, Hyungsin Kim, Young Dong Yoo, Changhoon Ji, Seong Hye Park, Kyung Jae Park, Deric M. Park, Yong J. Lee, Seung-Ki Kim, Kim Bo Yeon, Seung Ah Choi, Aaron Ciechanover, Yong Tae Kwon, Hyunjoo Cha-Molstad
Although proteasome inhibitors (PIs) are used as anticancer drugs to treat various cancers, their relative therapeutic efficacy on stem cells vs. bulk cancers remains unknown. Here, we show that stem cells derived from gliomas, GSCs, are up to 1,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034fb9c71b3cc892afa2853f84d3f13c
https://europepmc.org/articles/PMC5210095/
https://europepmc.org/articles/PMC5210095/
Publikováno v:
Molecular Cancer Research. 10:1567-1579
Colorectal cancer is the third leading cause of cancer-related mortality in the world. The main cause of death because of colorectal cancer is hepatic metastases, which can be treated using isolated hepatic perfusion (IHP), allowing treatment of colo
Autor:
Marco A. Alcala, Hyounsoo Uh, Yong J. Lee, Ruth A. Modzelewski, Shu Ying Kwan, Kristy A. Gogick, David L. Bartlett, Stéphane Petoud, Adam R. Meier, Matthias Bischof, Chad M. Shade, Timothy G. Strein, Charles K. Brown, Zachary P. Thompson
Publikováno v:
Biomaterials
Biomaterials, Elsevier, 2011, 32 (35), pp.9343-52. ⟨10.1016/j.biomaterials.2011.07.076⟩
Biomaterials, Elsevier, 2011, 32 (35), pp.9343-52. ⟨10.1016/j.biomaterials.2011.07.076⟩
International audience; We have created a dendrimer complex suitable for preferential accumulation within liver tumors and luminescence imaging by substituting thirty-two naphthalimide fluorophores on the surface of the dendrimer and incorporating ei
Publikováno v:
Journal of Biological Chemistry. 286:20087-20099
Here, we demonstrate that troglitazone (Rezulin), a peroxisome proliferator-activated receptor agonist, acted in synergy with heregulin to induce massive cell death in breast cancer cells. Although the combination of heregulin and troglitazone (HRG/T