Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrycja Gazinska"'
Autor:
Anthony Cheung, Diana Dominguez Rodriguez, Mariangela Figini, James Spicer, Anita Grigoriadis, Cheryl Gillett, Nirmesh Patel, James W. Opzoomer, Angela Clifford, Matthew Fittall, Giulia Pellizzari, Patrycja Gazinska, Hasan Mirza, Luned M. Badder, Andrew Tutt, Frank O. Nestle, Daniel Larcombe-Young, Silvia Mele, Debra H. Josephs, Rebecca Marlow, Sophia N. Karagiannis, Silvia Crescioli, Sarah E Pinder, Heather J. Bax, Gyula M. Petranyi, Erika Francesch-Domenech, Silvana Canevari, Ricarda M. Hoffmann, Kristina M. Ilieva
Publikováno v:
Cheung, A, Opzoomer, J W, Ilieva, K M, Gazinska, P, Hoffmann, R M, Mirza, H, Marlow, R, Francesch-Domenech, E, Fittall, M W, Dominguez Rodriguez, D, Clifford, A, Badder, L, Patel, N, Mele, S, Pellizzari, G, Bax, H J, Crescioli, S, Petranyi, G, Larcombe-Young, D, Josephs, D H, Canevari, S, Figini, M, Pinder, S E, Nestle, F O, Gillett, C, Spicer, J, Grigoriadis, A, Tutt, A & Karagiannis, S N 2018, ' Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer ', Clinical Cancer Research, vol. 24, no. 20, pp. 5098-5111 . https://doi.org/10.1158/1078-0432.CCR-18-0652
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3bf16519826e1575a3ac479dab144a
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
Autor:
Ilirjana, Bajrami, Rebecca, Marlow, Marieke, van de Ven, Rachel, Brough, Helen N, Pemberton, Jessica, Frankum, Feifei, Song, Rumana, Rafiq, Asha, Konde, Dragomir B, Krastev, Malini, Menon, James, Campbell, Aditi, Gulati, Rahul, Kumar, Stephen J, Pettitt, Mark D, Gurden, Marta Llorca, Cardenosa, Irene, Chong, Patrycja, Gazinska, Fredrik, Wallberg, Elinor J, Sawyer, Lesley-Ann, Martin, Mitch, Dowsett, Spiros, Linardopoulos, Rachael, Natrajan, Colm J, Ryan, Patrick W B, Derksen, Jos, Jonkers, Andrew N J, Tutt, Alan, Ashworth, Christopher J, Lord
Publikováno v:
Bajrami, I, Marlow, R, van de Ven, M, Brough, R, Pemberton, H N, Frankum, J, Song, F, Rafiq, R, Konde, A, Krastev, D B, Menon, M, Campbell, J, Gulati, A, Kumar, R, Pettitt, S J, Gurden, M D, Cardenosa, M L, Chong, I, Gazinska, P, Wallberg, F, Sawyer, E J, Martin, L-A, Dowsett, M, Linardopoulos, S, Natrajan, R, Ryan, C J, Derksen, P W B, Jonkers, J, Tutt, A N J, Ashworth, A & Lord, C J 2018, ' E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer ', Cancer discovery, vol. 8, no. 4, pp. 498-515 . https://doi.org/10.1158/2159-8290.CD-17-0603
Cancer Discovery, 8(4), 498. American Association for Cancer Research Inc.
Cancer discovery, vol 8, iss 4
Cancer Discovery, 8(4), 498. American Association for Cancer Research Inc.
Cancer discovery, vol 8, iss 4
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::24b9226c5040508d02ebf52140d0bf85
https://kclpure.kcl.ac.uk/ws/files/94235825/E_Cadherin_ROS1_Inhibitor_BAJRAMI_Accepted23January2018_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/94235825/E_Cadherin_ROS1_Inhibitor_BAJRAMI_Accepted23January2018_GREEN_AAM.pdf
Autor:
Cheryl Gillett, Hasan Mirza, Markus Mayrhofer, Maggie C.U. Cheang, Vandna Shah, Johnathan Watkins, Shalaka Joshi, Maria Jasin, Alan Ashworth, Fabio Vanoli, Andrew Tutt, Bhavna Sidhu, Anders Isaksson, Anita Grigoriadis, Shaveta Vinayak, Melinda L. Telli, Patrycja Gazinska, Sarah E Pinder, Jessica Frankum, Christopher J. Lord, Daniel Weekes, James M. Ford
Publikováno v:
Cancer discovery, vol 5, iss 5
Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particu
Autor:
Paul Ellis, Simon Ameer-Beg, Sarah E Pinder, Simon P. Poland, Rachel Evans, Cheryl Gillett, David R. Withers, Frank McCaughan, Leo M. Carlin, Sheeba Irshad, Patrick Gordon, Uzma Hasan, Dominic Patel, Sergio A. Quezada, Tony Ng, Anita Grigoriadis, Stewart G. Martin, Felix Wong, Julie Owen, Natalie Woodman, Katherine Lawler, Anthony Cheung, Borivoj Vojnovic, Manuel Rodriguez-Justo, Paul R. Barber, Gilbert O. Fruhwirth, Patrycja Gazinska, Victoria Male, Peter J. L. Lane, Fabian Flores-Borja, Andrew Tutt, Farzana Noor, James Monypenny
Publikováno v:
Irshad, S, Flores-Borja, F, Lawler, K, Monypenny, J, Evans, R, Male, V, Gordon, P, Cheung, A, Gazinska, P, Noor, F, Wong, F, Grigoriadis, A, Fruhwirth, G O, Barber, P R, Woodman, N, Patel, D, Rodriguez-Justo, M, Owen, J, Martin, S G, Sarah, E P, Cheryl, E G, Poland, S P, Ameer-Beg, S, McCaughan, F, Carlin, L M, Hasan, U, Withers, D R, Lane, P, Vojnovic, B, Quezada, S A, Ellis, P, Tutt, A N J & Ng, T 2017, ' RORγt + innate lymphoid cells promote lymph node metastasis of breast cancers ', Cancer Research, vol. 77, no. 5, pp. 1083-1096 . https://doi.org/10.1158/0008-5472.CAN-16-0598
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c12353ce206bad7e076bc88766252d3
https://kclpure.kcl.ac.uk/ws/files/62873523/Revised_Manuscript_Final.pdf
https://kclpure.kcl.ac.uk/ws/files/62873523/Revised_Manuscript_Final.pdf
Autor:
Paul S. Jones, Ana Montes, Panagiotis Karagiannis, Debra H. Josephs, Silvana Canevari, Philip J. Blower, Mano Nakamura, Sophia N. Karagiannis, Heike Lentfer, Cecilia Herraiz, Anthony Cheung, Christopher Corrigan, David Dombrowicz, Elliott Lever, Noel Downes, Matthew Fittall, Giulia Chiaruttini, Natalie Woodman, Silvia Crescioli, Mirella Georgouli, Louise Saul, Mariangela Figini, Andrew J. Beavil, Alexander Koers, Silvia Mele, Christopher Selkirk, Amy E. Gilbert, Heather J. Bax, Hannah J. Gould, Claire Barton, Giulia Pellizzari, Victoria Sanz-Moreno, Isabel Correa, Sophia Tsoka, Patrycja Gazinska, Kristina M. Ilieva, James Spicer, Marguerite G. Bracher, Tihomir Dodev, Gareth Muirhead, Frank O. Nestle
Publikováno v:
Josephs, D H, Bax, H J, Dodev, T, Georgouli, M, Nakamura, M, Pellizzari, G, Saul, L, Karagiannis, P, Cheung, A, Herraiz, C, Ilieva, K M, Correa, I, Fittall, M, Crescioli, S, Gazinska, P, Woodman, N, Mele, S, Chiaruttini, G, Gilbert, A E, Koers, A, Bracher, M, Selkirk, C, Lentfer, H, Barton, C, Lever, E, Muirhead, G, Tsoka, S, Canevari, S, Figini, M, Montes, A, Downes, N, Dombrowicz, D, Corrigan, C J, Beavil, A J, Nestle, F O, Jones, P S, Gould, H J, Sanz-Moreno, V, Blower, P J, Spicer, J F & Karagiannis, S N 2017, ' Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNFa/MCP-1 signaling ', Cancer Research, vol. 77, no. 5, pp. 1127-1141 . https://doi.org/10.1158/0008-5472.CAN-16-1829
IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re
Autor:
Sheeba, Irshad, Fabian, Flores-Borja, Katherine, Lawler, James, Monypenny, Rachel, Evans, Victoria, Male, Peter, Gordon, Anthony, Cheung, Patrycja, Gazinska, Farzana, Noor, Felix, Wong, Anita, Grigoriadis, Gilbert O, Fruhwirth, Paul R, Barber, Natalie, Woodman, Dominic, Patel, Manuel, Rodriguez-Justo, Julie, Owen, Stewart G, Martin, Sarah E, Pinder, Cheryl E, Gillett, Simon P, Poland, Simon, Ameer-Beg, Frank, McCaughan, Leo M, Carlin, Uzma, Hasan, David R, Withers, Peter, Lane, Borivoj, Vojnovic, Sergio A, Quezada, Paul, Ellis, Andrew N J, Tutt, Tony, Ng
Publikováno v:
Cancer research. 77(5)
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the
Autor:
Zakka L, Pascal Meier, Pierfrancesco Marra, Plumb Da, Maurizio Scaltriti, Patrycja Gazinska, Anita Grigoriadis, Steven Catchpole, Erika Francesch-Domenech, McEachern K, Johnathan Watkins, Fara Braso-Maristany, Sumi Mathew, Simone Filosto, Andrew Tutt, Nirmesh Patel, Pau Castel, Perdrix-Rosell A, Elodie Noel, Rebecca Marlow, Gianmaria Liccardi, Maggie C.U. Cheang, Albert Gris-Oliver, Manar S. Shafat, Jelmar Quist, Serra, Farzana Noor, Richard Buus
Publikováno v:
Nature medicine. 22(11)
Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant ma