Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nelofer Syed"'
Autor:
Tim Crook, Eirinaios I. Vrettos, Antonis D. Tsiailanis, Marie-Isabel Aguilar, Thomas Mavromoustakos, Nelofer Syed, Georgios S. Markopoulos, Alexander Renziehausen, Mark P. Del Borgo, Robert E Widdop, Nisar Sayyad, Evangelos Kolettas, Andreas G. Tzakos, Sofia Kiriakidi, Baydaa Hirmiz
Publikováno v:
Free Radical Biology and Medicine. 160:391-402
Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Maximal surgical resection followed by radiotherapy and concomitant chemotherapy with temozolomide remains the first-line therapy, prolonging the survival
Autor:
Gregory Sivolapenko, Andreas G. Tzakos, Evgenios K. Stylos, Tim Crook, Nelofer Syed, Maria V. Chatziathanasiadou, Evangelos Briasoulis, Maria-Helen Spyridaki, Haralabos P. Kalofonos, Efstathia Giannopoulou
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 164:690-697
Sunitinib is a multi-targeted tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor and is currently being investigated against other forms of malignant tumors. Recently gre
Autor:
Antonis D, Tsiailanis, Alexander, Renziehausen, Serdar, Karakurt, Tim, Crook, Nelofer, Syed, Andreas G, Tzakos
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2207
Cancer occupies a high rank in the global morbidity and mortality scale with glioblastoma multiforme (GBM) accounting for almost 80% of all primary tumors of the brain. Despite the increasing availability of targeted and immunotherapeutic agents, che
Autor:
Nabil Hajji, Juan Garcia-Revilla, Manuel Sarmiento Soto, Richard Perryman, Jake Symington, Chad C. Quarles, Deborah R. Healey, Yijie Guo, Manuel Luis Orta-Vázquez, Santiago Mateos-Cordero, Khalid Shah, John Bomalaski, Giulio Anichini, Andreas G. Tzakos, Timothy Crook, Kevin O’Neill, Adrienne C. Scheck, Jose Luis Venero, Nelofer Syed
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
instname
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20
Autor:
Andrée Delahaye-Duriez, Julianna Stylianou, Kirill Shkura, Federico Roncaroli, Sarah R. Langley, Nelofer Syed, Albert J. Becker, Prashant K. Srivastava, Liisi Laaniste, Enrico Petretto, Qingyu Zeng, Marvin Johnson, Kevin O’Neill, Matthew Williams, Owen J. L. Rackham, Silvia Cases-Cunillera
Publikováno v:
Laaniste, L, Srivastava, P K, Stylianou, J, Syed, N, Cases-Cunillera, S, Shkura, K, Zeng, Q, Rackham, O J L, Langley, S R, Delahaye-Duriez, A, O'Neill, K, Williams, M, Becker, A, Roncaroli, F, Petretto, E & Johnson, M R 2019, ' Integrated systems-genetic analyses reveal a network target for delaying glioma progression ', Annals of clinical and translational neurology, vol. 6, no. 9, pp. 1616-1638 . https://doi.org/10.1002/acn3.50850
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)
Annals of Clinical and Translational Neurology
OBJECTIVE: To identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy discovery.METHODS: Using an integrated functional genomics approach, we prioritized networks associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9856ad195da8e008d955d780c30cc79
https://www.research.manchester.ac.uk/portal/en/publications/integrated-systemsgenetic-analyses-reveal-a-network-target-for-delaying-glioma-progression(289e59de-ac87-4ea5-992b-bc9d64d85778).html
https://www.research.manchester.ac.uk/portal/en/publications/integrated-systemsgenetic-analyses-reveal-a-network-target-for-delaying-glioma-progression(289e59de-ac87-4ea5-992b-bc9d64d85778).html
Autor:
Nabil Hajji, Alexander Renziehausen, Su Li, Maria del Carmen Fernandez-Carranco, Alan Evans, Van Ren Sim, Rubeta N Matin, Bhavya Rao, Marco Merlano, Catherine A. Harwood, Justin Stebbing, Laura Lattanzio, Nelofer Syed, Lynda Weir, Cristiana Lo Nigro, Kevin O’Neill, Andreas G. Tzakos, Charlotte M. Proby, Antonio Vega-Rioja, He-Xiao Wang, Peter W. Szlosarek, Alastair M. Thompson, Colin Fleming, Tim Crook
Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1876b0b1f9ba73775c7e2425f9f2c4c
https://hdl.handle.net/10668/13242
https://hdl.handle.net/10668/13242
Autor:
Christos M. Chatzigiannis, Andreas G. Tzakos, Evgenios K. Stylos, Richard Perryman, Kevin O’Neill, Antonis D. Tsiailanis, Tim Crook, Alexander Renziehausen, Nelofer Syed
Publikováno v:
Molecular cancer therapeutics. 18(9)
The alkylating agent temozolomide (TMZ) is the first-line chemotherapeutic for glioblastoma (GBM), a common and aggressive primary brain tumor in adults. However, its poor stability and unfavorable pharmacokinetic profile limit its clinical efficacy.
Autor:
Alan Evans, L. Weir, Aithne Atkinson, Colin Fleming, Tim Crook, Alexander Renziehausen, Rubeta Matin, J. Geoffrey Pickering, Su Li, Peter W. Szlosarek, Laura Lattanzio, Ronald T. Raines, Marco Merlano, Van Ren Sim, Alastair M. Thompson, Hexiao Wang, James T. Vasta, Catherine A. Harwood, Cristiana Lo Nigro, Charlotte M. Proby, Mathieu Boniol, Nelofer Syed, Bhavya Rao
Publikováno v:
J Invest Dermatol
Other repository
Other repository
Appropriate post-translational processing of collagen requires prolyl hydroxylation, catalyzed by collagen prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase, and is essential for normal cell function. Here we have investigated the expression, tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3351c8f939c7481a5da5b730022427
http://hdl.handle.net/10044/1/65729
http://hdl.handle.net/10044/1/65729
Autor:
Nelofer Syed, Lina Mörén, Henrik Antti, Richard Perryman, Tim Crook, Kevin O’Neill, Julia K. Langer
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-1 (2018)
BMC Cancer
BMC Cancer
Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1). These tumours are auxotrop
Autor:
Kevin O’Neill, Henrik Antti, Nelofer Syed, Tim Crook, Richard Perryman, Lina Mörén, Julia K. Langer
Publikováno v:
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Background: Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1). These tumours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0425f735e70faa79a92e89c27ea1a40
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145374
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145374