Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lucia Knopfová"'
Autor:
Kamila Říhová, Monika Dúcka, Iva Staniczková Zambo, Ladislava Vymětalová, Martin Šrámek, Filip Trčka, Jan Verner, Stanislav Drápela, Radek Fedr, Tereza Suchánková, Barbora Pavlatovská, Eva Ondroušková, Irena Kubelková, Danica Zapletalová, Štěpán Tuček, Peter Múdry, Dagmar Adámková Krákorová, Lucia Knopfová, Jan Šmarda, Karel Souček, Lubor Borsig, Petr Beneš
The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival when aberrantly activated/expressed, thus contributing to malignant transformation. Overexpression of c-Myb has been found in leukemias, breast, colon and aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b04ff593300ff6bdf0cde2b3cfb8ff
https://www.zora.uzh.ch/id/eprint/226453/
https://www.zora.uzh.ch/id/eprint/226453/
Autor:
Lubor Borsig, Darya Protsyuk, Sandra Grässle, Volker Huck, Irina Häuselmann, Alexander Bauer, Marko Roblek, Stefan W. Schneider, Lucia Knopfová
Publikováno v:
Cancer Research
Tumor cells interact with blood constituents and these interactions promote metastasis. Selectins are vascular receptors facilitating interactions of tumor cells with platelets, leukocytes, and endothelium, but the role of endothelial E-selectin rema
Publikováno v:
Cellular signalling
The c-Myb transcription factor is important for maintenance of immature cells of many tissues including colon epithelium. Overexpression of c-Myb occurring in colorectal carcinomas (CRC) as well as in other cancers often marks poor prognosis. However
Autor:
Sára Lenárt, Šárka Šimečková, Radek Fedr, Zuzana Kahounová, Jan Bouchal, Petr Beneš, Gvantsa Kharaishvili, Lucia Binó, Eva Slabáková, Milan Král, Tereza Kučírková, Ján Remšík, Lucia Knopfová, Karel Souček, Ximena Maria Muresan
Publikováno v:
Carcinogenesis. 39(11)
The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype i
Autor:
Vojtech Adam, Petr Babula, Monika Holubová, Martina Raudenská, Markéta Sztalmachová, Michal Masarik, Jaromír Gumulec, Jan Balvan, Hana Polanska, René Kizek, Lucia Knopfová, Kristyna Hudcova
Publikováno v:
International Journal of Oncology. 46:1810-1818
Breast cancer patients negative for the nuclear oestrogen receptor α have a particularly poor prognosis. Therefore, the 4T1 cell line (considered as a triple-negative model) was chosen to induce malignancy in mice. The aim of the present study was t
Autor:
Pavel Kopel, Lukas Nejdl, Lucia Knopfová, Markéta Sztalmachová, Martina Raudenská, Marie Stiborová, Michal Masarik, Jana Vlachova, René Kizek, Michaela Fojtu, Vojtech Adam, Petr Babula, Anna Skotakova, Sylvie Skalickova, Jaromír Gumulec
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22960-22977 (2014)
International Journal of Molecular Sciences. 2014, vol. 15, issue 12, p. 22960-22977.
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 22960-22977
International Journal of Molecular Sciences. 2014, vol. 15, issue 12, p. 22960-22977.
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 22960-22977
Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthes
Autor:
Michal Masarik, Veronika Dvorakova, Martina Raudenská, Hana Polanska, René Kizek, Vojtech Adam, Jaromír Gumulec, Kristyna Hudcova, Lucia Knopfová, Jan Balvan, Petr Babula, Branislav Ruttkay-Nedecky, Marie Stiborová, Markéta Sztalmachová
Publikováno v:
International Journal of Oncology. 44:923-933
Differences in the antioxidant system, apoptotic mechanism and in cell cycle between prostatic cell lines could partially elucidate the development of cisplatin resistance. The aim of this study was to identify the most characteristic parameter for a
Publikováno v:
Environmental and Molecular Mutagenesis. 53:515-524
Wedelolactone is one of the active plant polyphenolic compounds. Anti-tumor effects of this drug have been demonstrated recently. We have described that wedelolactone acts as catalytic inhibitor of DNA topoisomerase IIα. The aim of this study was to
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(8)
Cathepsin D (CD), a ubiquitously expressed lysosomal aspartic protease, is upregulated in human breast carcinoma and many other tumor types. CD has been repeatedly reported to act as key mediator of apoptosis induced by various chemotherapeutics. How
Autor:
Lucia Knopfová, Miroslav Fojta, Diana Pinheiro, Filip Trčka, Karel Souček, Petr Beneš, Alice Nemajerova, Jan Šmarda
Publikováno v:
Cancer letters. 303(1)
The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFκB transcription factor and/or