Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Katerine Van Rietschoten"'
Autor:
Gemma E. Mudd, Heather Scott, Liuhong Chen, Katerine van Rietschoten, Gabriela Ivanova-Berndt, Katarzyna Dzionek, Amy Brown, Sophie Watcham, Lewi White, Peter U. Park, Phil Jeffrey, Mike Rigby, Paul Beswick
Publikováno v:
Journal of medicinal chemistry. 65(21)
Bicycle toxin conjugates (BTCs) are a promising new class of molecules for targeted delivery of toxin payloads into tumors. Herein we describe the discovery of BT8009, a Nectin-4 targeting BTC currently under clinical evaluation. Nectin-4 is overexpr
Autor:
Eric Haines, Katerine Van Rietschoten, Punit Upadhyaya, Marianna Kleyman, Elizabeth Repash, Tom Li Stephen, Jessica Kublin, Johanna Lahdenranta, Sailaja Battula, Rachel Dods, Kristen Hurov, Jun Ma, Nicholas Keen, Rachid Lani, Gemma Mudd, Philip Brandish, Julia Kristensson, Kevin Mcdonnell, Helen Harrison, Liuhong Chen, Fanglei You
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
BackgroundIn contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed. We sought to address this problem using a new class of modular synthetic drugs, term