Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Isacchi A"'
Autor:
Francesco Casuscelli, Elena Ardini, Nilla Avanzi, Alessandra Badari, Elena Casale, Teresa Disingrini, Daniele Donati, Antonella Ermoli, Eduard R. Felder, Arturo Galvani, Antonella Isacchi, Maria Menichincheri, Marisa Montemartini, Christian Orrenius, Claudia Piutti, Barbara Salom, Gianluca Papeo
Publikováno v:
Chirality. 34:1437-1452
We previously demonstrated that natural product-inspired 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones derivatives delivered potent and selective PIM kinases inhibitors however with non-optimal ADME/PK properties and modest oral bioavailability. Herein
Autor:
Laura Raddrizzani, Antonella Leone, Giovanni Carapezza, Carlo Cusi, Alessio Somaschini, Sebastiano Di Bella, Antonella Isacchi, Tommaso Mazza, Roberta Bosotti
Publikováno v:
Scientific Data
Inhibition of kinase gene fusions (KGFs) has proven successful in cancer treatment and continues to represent an attractive research area, due to kinase druggability and clinical validation. Indeed, literature and public databases report a remarkable
Autor:
Alessia Montagnoli, Nadia Amboldi, Fabio Bozzi, Roberta Bosotti, Arturo Galvani, Silvana Pilotti, Barbara Salom, Josh Sommer, Alessio Somaschini, Christian Orrenius, Laura Raddrizzani, Dario Ballinari, Silvia Stacchiotti, Elena Tamborini, Antonella Isacchi, Liviana Cozzi, Fabio Gasparri, Paola Magnaghi
Publikováno v:
Molecular Cancer Therapeutics. 17:603-613
Chordomas are rare bone tumors with no approved therapy. These tumors express several activated tyrosine kinase receptors, which prompted attempts to treat patients with tyrosine kinase inhibitors. Although clinical benefit was observed in phase II c
Autor:
Fabio Bozzi, Nicola Beltrami, Roberta Bosotti, Rosita Lupi, Barbara Salom, Nadia Amboldi, Giovanni Carapezza, Arturo Galvani, Silvia Stacchiotti, Paola Magnaghi, Elena Tamborini, Liviana Cozzi, Dario Ballinari, Carlo Cusi, Antonella Isacchi, Alessio Somaschini, Sebastiano Di Bella, Laura Raddrizzani
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Chordomas are rare, slowly growing tumors with high medical need, arising in the axial skeleton from notochord remnants. The transcription factor “brachyury” represents a distinctive molecular marker and a key oncogenic driver of chordomas. Tyros
Autor:
Achille Panzeri, G. Canevari, Sabrina Cribioli, Nadia Amboldi, Nilla Avanzi, Paola Gnocchi, Jay Bertrand, Arturo Galvani, Marina Ciomei, Simona Bindi, Eduard R. Felder, Gabriele Fachin, Ilaria Motto, Antonella Isacchi, Daniele Casero, Daniele Donati, Nicoletta Colombo, Maria Gabriella Brasca, Marcella Nesi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2387-2407
Compound 1, a hit from the screening of our chemical collection displaying activity against JAK2, was deconstructed for SAR analysis into three regions, which were explored. A series of compounds was synthesized leading to the identification of the p
Autor:
Manuela Iezzi, Federica Papaccio, Diego di Bernardo, Fabrizio Loreni, Alberto Bardelli, Laura Ciolli, Francesco Sirci, Vittorio Enrico Avvedimento, Margherita Mutarelli, Marcella Mottolese, Valentina Aria, Roberta Bosotti, Luca Cardone, Carla Azzurra Amoreo, Antonella Isacchi, Rosanna Dattilo, Barbara Tumaini, Diego Carrella, Isabella Manni
Publikováno v:
Oncotarget
// Diego Carrella 1 , Isabella Manni 3 , Barbara Tumaini 1 , Rosanna Dattilo 2 , Federica Papaccio 3 , Margherita Mutarelli 1 , Francesco Sirci 1 , Carla A. Amoreo 4 , Marcella Mottolese 4 , Manuela Iezzi 5 , Laura Ciolli 5 , Valentina Aria 6 , Rober
Autor:
Jason Harris, Anna Degrassi, Gang Li, Tiziano Bandiera, Arturo Galvani, Ge Wei, David F. Anderson, Marina Ciomei, Cristina De Ponti, Eduard R. Felder, Patrizia Banfi, Daniele Casero, Antonella Isacchi, Jean-Michel Vernier, Daniele Donati, Maria Menichincheri, Paolo Orsini, Gemma Texido, Maria Beatrice Saccardo, Nilla Avanzi, Enrico Pesenti, Dario Ballinari, Nadia Amboldi, Luca Mologni, Paola Magnaghi, Elena Ardini, Romana Pulci, Roberta Bosotti
Publikováno v:
Molecular cancer therapeutics. 15(4)
Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements, occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and their oncogenic relevance as actionable targets has been demonstrated by t
Autor:
Laura Riceputi, Eduard R. Felder, Francesco Sola, Claudio Dalvit, Elena Casale, Arturo Galvani, Carlo Visco, Nadia Amboldi, Francesco Casuscelli, Antonella Isacchi, Gianpaolo Fogliatto, Paolo Polucci, Nicoletta Colombo, Fabio Zuccotto, Maria Gabriella Brasca, Dannica Caronni
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4135-4150
In the last decade the heat shock protein 90 (Hsp90) has emerged as a major therapeutic target and many efforts have been dedicated to the discovery of Hsp90 inhibitors as new potent anticancer agents. Here we report the identification of a novel cla
Autor:
Federico Riccardi Sirtori, Monica Patanè, Bianca Pollo, Ileana Zucca, Antonella Isacchi, Maria Grazia Bruzzone, Serena Pellegatta, Gianpaolo Fogliatto, Lorella Valletta, Cristina Corbetta, Gaetano Finocchiaro
Publikováno v:
Acta Neuropathologica Communications
The R132H mutation of cytosolic isocitrate dehydrogenase (IDH1) is present in the majority of low grade gliomas. Immunotherapy in these tumors has an interesting, still unexploited, therapeutic potential, as they are less immunosuppressive than gliob
Autor:
Arturo Galvani, Nadia Amboldi, Fabio Gasparri, Antonella Isacchi, G Ukmar, Alessio Somaschini, Antonella Landonio, Angelo Nuzzo, Emanuela Scacheri, Dario Ballinari, Jan Malyszko, Laura Raddrizzani, Roberta Bosotti
Publikováno v:
Genetic Testing and Molecular Biomarkers. 17:254-259
The generation of biological data on wide panels of tumor cell lines is recognized as a valid contribution to the cancer research community. However, research laboratories can benefit from this knowledge only after the identity of each individual cel